A kind of preparation method of extract of effective fractions of A. japonicus

Abstract

The invention discloses a preparation method of an alligator alternanthera effective fraction extract, which comprises the following steps: 1. extracting alligator alternanthera with alcohol under reflux; 2. recycling the alcohol extract under reduced pressure, diluting the medicinal liquor, and filtering; 3. adsorbing the filtrate through D101 macroporous adsorbent resin columns, and eluting with distilled water and alcohols with different concentrations; and 4. recycling the eluent under reduced pressure, concentrating to a relative density of 1.01-1.10, and drying to obtain the alligator alternanthera effective fraction extract. The general flavone content of the alligator alternanthera effective fraction extract product is up to 3-5 wt%, the transfer rate is 50-70%; and the general saponin content is up to 15-18 wt%, and the transfer rate is 40-60%. No related data about the preparation technique of the effective fraction extract has been reported at home and abroad. The inventionhas the advantages of simple extraction and purification technique and higher content of effective substances, lowers the production cost, saves the energy, reduces the potential safety hazard in theproduction, and satisfies the modern requirements for traditional Chinese medicine industry.

Description

technical field [0001] The invention belongs to the technical field of extracting and purifying effective fractions of traditional Chinese medicines, and more specifically relates to a preparation method of an extract of effective fractions of A. japonicus. The method can effectively extract total flavonoids and total saponins in A. japonicus. Background technique [0002] Alternanthera philoxeroides (Mart.) Griseb is a perennial herbaceous plant of Amaranthaceae (Amaranthaceae) Alternanthera. effect. It has been reported in the literature in the past 20 years that Asteroides japonicus has anti-virus, immune-regulating, and anti-liver damage effects. It is clinically used to treat viral diseases such as urticaria, influenza, Japanese encephalitis, and epidemic hemorrhagic fever. Nutella plants contain a variety of chemical components, and the chemical components that have been isolated and identified so far include: triterpenoids, flavonoids, alkaloids, lactams, organic aci...

AI Technical Summary

Problems solved by technology

This method is backward in technology, uncontrollable in quality, and very easy to cause lead poisoning, so this preparation process will not be included in the future pharmacopoeia

At present, there are no reports on the extraction and purification methods of the effective substances of A. japonicus. However, there are few effective antiviral drugs at home and abroad, and antiviral drugs are still a hot spot for domestic and foreign scholars.

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