A micropump based on capillary action and its application method

Abstract

The invention relates to a method for using a micropump based on capillary action, characterized in that the micropump is composed of a capillary pump chamber, a partition valve, a sample feeding micropipe and a liquid storage microchamber, wherein the capillary pump chamber is a micropipeline network The separation valve is a micropipe or microcavity connecting the capillary pump cavity and the micropipe for sampling; the micropipe for sampling is a micropipe between the inlet and the microcavity for the liquid storage, and the microcavity for the liquid storage is a culture chamber Or the reaction chamber, located at the end of the sampling micropipe. How to use the micropump: 1) Add samples or reagents into the injection port, so that it is driven by capillary force to fill the micropipe for sampling, and stop at the entrance of the microcavity for the liquid storage due to the action of the capillary microvalve; 2) In the capillary pump The driving liquid is added to the entrance of the chamber, and the driving liquid will fill the capillary pump chamber under the capillary force and compress the air in it to generate driving pressure, thereby dividing and pushing the sample or reagent into the microcavity of the micropipe for sampling. The provided micropumps can also be used in combination to realize quantitative micromixing, reaction or cell culture.

Description

technical field [0001] The invention relates to a micropump based on capillary action and its application method, which can be applied to micro-biochemical reactors and lab-on-chips. Background technique [0002] In recent years, microfluidic systems, as a new technology platform, have received widespread attention in the fields of biology and chemistry. Such systems are usually called Micro Total Analysis Systems or Labs-on-a-chip. -Chip), it is often necessary to perform processes such as sampling, mixing, separation, and detection. Most of these processes are inseparable from the control of microfluidics. Achieved. As the core component of the microfluidic control system, the micropump is the power element to realize the supply of trace liquid and precise control. There are many types of micropumps, which can be roughly divided into mechanical micropumps and non-mechanical micropumps. Mechanical micropumps often rely on moving parts to transmit and control fluids, while...

AI Technical Summary

Problems solved by technology

According to the driving principle, mechanical micropumps mainly include piezoelectric type, thermopneumatic type, electrostatic type, electromagnetic type, shape memory alloy type, etc. This type of micropump usually has complicated manufacturing process, high cost, high power consumption, and long-term working reliability. Less robust and difficult to integrate

Non-mechanical micropumps mainly include electroosmotic, electrowetting, sonic, magnetic fluid, evaporative, etc. This type of micropump has certain advantages in reliability, and there will be no membrane deformation under the long-term working condition of mechanical micropumps. Fatigue and other issues, but this type of micropump requires complex drive circuits or devices. Such additional components often increase the complexity of the system and reduce the portability of the system, thus limiting the application range of the microfluidic system

Images