Application of 17a alpha-D-homo-ethynylestradiol-3-ethyl ester in preparation of medicines for treating radiation induced aplasticanemia

A technology for aplastic anemia and high ethinyl estradiol, which is applied in drug combinations, blood diseases, and pharmaceutical formulations, and can solve problems such as large side effects, high cost of long-term immunosuppressive agents, and difficulty in matching bone marrow transplantation.

Inactive Publication Date: 2013-07-03
INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

At present, the widely used clinical treatment methods have shortcomings, such as androgen method is not effective in improving platelets and has large side effects, bone marrow transplantation method is difficult to match and the cost of long-term immunosuppressant is high, and immunosuppressant method is costly and far-reaching. Severe complications in the early stage; the development of a safe, effective, and low-cost treatment for aplastic anemia has good clinical application prospects

Method used

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  • Application of 17a alpha-D-homo-ethynylestradiol-3-ethyl ester in preparation of medicines for treating radiation induced aplasticanemia
  • Application of 17a alpha-D-homo-ethynylestradiol-3-ethyl ester in preparation of medicines for treating radiation induced aplasticanemia
  • Application of 17a alpha-D-homo-ethynylestradiol-3-ethyl ester in preparation of medicines for treating radiation induced aplasticanemia

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Purpose

[0027] Observation of the therapeutic effect of E838 on the peripheral blood of aplastic mice

[0028] Experimental Materials

[0029] 1. Experimental animals: BALB / C mice, DBA / 2 mice, male, provided by the Institute of Experimental Animals, Chinese Academy of Medical Sciences (certificate number: SCXK (Beijing) 2005-0013). The feed was clean-grade full-price mouse feed provided by Beijing Keao Xieli Feed Co., Ltd.

[0030] 2. Experimental equipment: Tianjin Institute of Physics and Technology 60Co source γ-rays, the dose is 5.0Gy, and the dose rate is 1.1Gy / min. Automatic blood analyzer (pocH-100i, Sysmex, Japan), paraffin slicer for paraffin blocks (LM2235, Leica, Germany), upright microscope (BX51, Olympus, Japan), camera (D90, Nikon, Japan).

[0031] 3. Reagent: E838 was developed by our institute (see ZL200510016408.9), and injection oil was provided by Tianjin Amino Acid Company. RPMI-1640 medium was purchased from SIGMA Company.

[0032] expe...

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Abstract

The invention discloses application of 17a alpha-D-homo-ethynylestradiol-3-ethyl ester (E838 for short) to preparation of medicines for treating the hematopoietic function of aplasticanemia (AA) mice and protecting radiation of mouse bone marrow cell chromosome. The E838 is used for treating radiation induced AA test animal models and damage of the mouse bone marrow cell chromosome caused by gamma ray irradiation, so an occurrence and development route for treating the ionizing radiation induced AA of the mice and damage of the mouse bone marrow cell chromosome caused by gamma ray irradiationis established.

Description

technical field [0001] The invention belongs to the technical field of chemically synthesized drugs, and relates to the application of E838 in the preparation of drugs for the treatment of radiation-induced aplastic anemia, more specifically 17a α-D-homoethinyl estradiol-3-ethyl ester (E838 for short) in Prevention and treatment of radiation-induced aplastic anemia in mice and application in prevention of radiation-induced bone marrow cell chromosome damage. Background technique [0002] The research on estrogen compounds has a history of several decades, and has a certain biological effect, but the application is often limited due to high estrogen activity and large side effects. Estrogen compounds have better prevention and treatment of radiation damage The role of estrogen as an anti-radiation drug has been studied abroad for nearly 60 years. Since the 1870s in China, it has been found that ethinyl estradiol and cyclopentyl ether-ethinyl estradiol have better preventive a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/56A61P7/06A61P7/00
Inventor 王月英孟爱民张恒李德冠吴红英王小春叶翔路璐杜丽清宋娜玲王彦褚丽萍常建辉张俊玲翟志斌
Owner INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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