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Method for preparing pharmaceutical excipient croscarmellose sodium from wood fiber

A technology of cross-linked carboxymethyl and pharmaceutical excipients, which is applied in pharmaceutical formulations, medical preparations with inactive ingredients, etc. Mild and easy-to-control coupling conditions, reliable composite performance, and reduced product cost

Inactive Publication Date: 2011-12-28
ANHUI SUNHERE PHARMA EXCIPIENTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature report on making pharmaceutical excipient croscarmellose sodium from wood fiber in China.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] ①Wood pulp is crushed, and a certain amount of wood pulp is cut into 2~6㎝?? small pieces by a crusher for use. The sodium hydroxide aqueous solution with a mass concentration of 48% is mixed with the ethanol aqueous solution with a mass concentration of 90% in a mass ratio of 1:1.5, and the mixed solution is cooled to 30°C.

[0020] ②Alkalization reaction: Add the mixed solution of wood pulp and sodium hydroxide that has been broken into 2~6cm?? small pieces into the kneader. Between 35°C, the reaction time is 55 minutes;

[0021] ③Etherification reaction: Add the material into the etherification tank after alkalization, add 95% ethanol to disperse, add the etherification agent after heating up to 55~60°C, raise the temperature to 75~80°C, and keep the reaction for 60 minutes; ④Crosslinking Reaction: After the etherification is completed, lower the temperature to 65~75°C, add a crosslinking agent, and keep the reaction for 180 minutes;

[0022] ⑤Neutralization: After ...

Embodiment 2

[0024] ①Wood pulp is crushed, and a certain amount of wood pulp is cut into 2~6㎝?? small pieces by a crusher for use. The sodium hydroxide aqueous solution with a mass concentration of 45% is mixed with the ethanol aqueous solution with a mass concentration of 95% in a mass ratio of 1:1.5, and the mixed solution is cooled to 30°C.

[0025] ②Alkalization reaction: Add the mixed solution of wood pulp and sodium hydroxide that has been broken into 2~6cm?? small pieces into the kneader. Between 35°C, the reaction time is 48 minutes;

[0026] ③Etherification reaction: Add the material into the etherification tank after alkalization, add 95% ethanol for dispersion, add etherification agent after heating up to 55~60°C, raise the temperature to 75~80°C, and keep the reaction for 70 minutes; ④Crosslinking Reaction: After the etherification is completed, lower the temperature to 65~75°C, add a crosslinking agent, and keep the reaction for 200 minutes;

[0027] ⑤Neutralization: After t...

Embodiment 3

[0029] ①Wood pulp is crushed, and a certain amount of wood pulp is cut into 2~6㎝?? small pieces by a crusher for use. The sodium hydroxide aqueous solution with a mass concentration of 45% and the ethanol aqueous solution with a mass concentration of 95% were uniformly mixed in a mass ratio of 1:1.5, and the mixed solution was cooled to 30°C.

[0030] ②Alkalization reaction: Add the mixed solution of wood pulp and sodium hydroxide that has been broken into 2~6cm?? small pieces into the kneader. Between 35°C, the reaction time is 48 minutes;

[0031] ③Etherification reaction: Add the material into the etherification tank after alkalization, add 95% ethanol for dispersion, add etherification agent after heating up to 55~60°C, raise the temperature to 75~80°C, and keep the reaction for 70 minutes; ④Crosslinking Reaction: After the etherification is completed, lower the temperature to 65~75°C, add a cross-linking agent, and keep the reaction for 240 minutes;

[0032] ⑤Neutraliza...

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Abstract

A method for preparing pharmaceutical excipient croscarmellose sodium from wood fiber, characterized in that the method steps are: a, cooling the mixed solution to below 30°C for use; b, alkalization reaction; c, etherification reaction ; d, cross-linking reaction; e, neutralization: add alkaline solution to adjust the pH value of the system, control the pH value of the material to 5.0-7.0, centrifugally dry, pulverize and sieve to obtain the pharmaceutical auxiliary material cross-linked carboxymethyl fiber Vegetarian Sodium. The technical effects of the invention are: the preparation of cross-linked sodium carboxymethyl cellulose as a medical auxiliary material from wood fiber is realized, the product cost is greatly reduced, the cross-linking conditions are mild and easy to control, and the compound has reliable performance and stable quality.

Description

technical field [0001] The invention relates to a method for preparing croscarmellose sodium, in particular to a method for preparing pharmaceutical auxiliary material croscarmellose sodium from wood fiber. Background technique [0002] Croscarmellose Sodium is white, fine granular powder, odorless and tasteless. Hygroscopic. It has a strong water swelling force and can form a suspension, which is slightly viscous. Insoluble in ethanol, ether and most organic solvents. [0003] Compared with sodium carboxymethyl cellulose, when croscarmellose sodium contacts water, it swells rapidly under the action of swelling force and is insoluble in water. It has a good disintegration effect and is a cellulose-type super disintegrant. , can disintegrate and dissolve rapidly. It is mainly used as a disintegrant in pharmaceuticals. It has good compressibility and strong disintegration, and can be used in all tableting processes. [0004] Croscarmellose sodium is used in or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B11/12C08J3/24C08L1/26A61K47/38
Inventor 毕勇周卫东朱岩陈晓雪张学全徐玉勋
Owner ANHUI SUNHERE PHARMA EXCIPIENTS
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