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Resibufogenin dry powder inhalant and preparation method and application thereof

A technology of leoptobufalin and dry powder inhaler, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, powder delivery, etc., can solve problems such as no research reports on similar preparations, and achieves improved bioavailability, Less adverse reactions and convenient application

Active Publication Date: 2013-05-15
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no research reports on similar preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation of inhalation: the lipobufagenin was pulverized to D 50 = 6 microns, mixed with lactose having a particle size of 30-80 microns in a mass ratio of 1:9, packing the drug powder into capsules or blisters or dry powder inhalers to obtain an inhaler.

Embodiment 2

[0025] Preparation of inhalation: the lipobufagenin was pulverized to D 50 = 7 microns, mixed with lactose with a particle size of 45-85 microns and leucine with a particle size of 28-55 microns in a ratio of 10:85:1, packed into capsules or blisters or dry powder inhalers to obtain inhalant.

Embodiment 3

[0027] Preparation of inhalation: the lipobufagenin was pulverized to D 50 =5 microns, mixed with leucine with a particle size of 50-125 microns at a ratio of 1:9, packed into capsules or blisters or dry powder inhalers to obtain an inhaler.

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PUM

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Abstract

The invention relates to a dry powder inhalant, in particular to a dry powder inhalant prepared from resibufogenin, a preparation method of the dry powder inhalant, and application of the dry powder inhalant to the preparation of a medicine for treating lung tumor. The resibufogenin dry powder inhalant is characterized by consisting of resibufogenin and a medically acceptable auxiliary material in a mass ratio of 1:0.02-1:100. The dry powder inhalant prepared from the resibufogenin can directly act on the lesion site of the lung, reduces toxic and side reactions, improves the bioavailability of the medicine, can overcome the defects that an oral preparation has slow response, a liver first pass effect, systemic toxic and side effects, low bioavailability and the like, and can solve the problems that an injection is inconvenient to use, low in patient compliance, and the like at the same time.

Description

Technical field: [0001] The invention relates to a dry powder inhaler, in particular to a dry powder inhaler made of lipobufagin, a preparation method of the dry powder inhaler and an application in the preparation of a drug for treating lung tumors. Background technique: [0002] Repobugenin is the main active ingredient in toad venom. It belongs to cardiac glycosides and is a fat-soluble substance. The molecular formula is: C 24 h 32 o 4 , has pharmacological effects such as anti-tumor, analgesic and cardiotonic, anti-inflammatory and immune-enhancing. Repobugenin has inhibitory effect on various cancer cells, such as lung cancer, gastric cancer, liver cancer, etc. The in vitro anti-tumor test shows that the tumor inhibition rate of repobugenin is 75%. At present, oral preparations containing redibufagenin have been used in clinical practice, and have good curative effects on liver cancer, lung cancer, gastric cancer, etc., with a comprehensive effective rate of 80.74%,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/72A61K9/14A61K31/585A61K47/26A61P11/00A61P35/00
Inventor 陈彦贾晓斌张振海王晋艳吴青青
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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