Fixed multi-nozzle complex organ precursor three-dimensional controlled forming system

Abstract

The invention provides a fixed multi-nozzle complex organ precursor three-dimensional controlled forming system, and belongs to the technical field of tissue engineering. The system mainly comprises a case body, a bracket, a fixed multi-nozzle injection device, a forming chamber, a forming table, a three-dimensional motion mechanism, a refrigeration device and a control and data processing system, wherein the fixed multi-nozzle injection device comprises a fixed nozzle scaffold and nozzle components; and the nozzle components are uniformly distributed on the fixed nozzle scaffold in a parallel or array way. When the precursor of a complex organ, such as liver, heart, kidney and the like, is formed, the forming chamber is cooled by utilizing a low-temperature deposition process principle, and a control system controls motion of the forming table and three-dimensional motion mechanism, as well as injection of the fixed multi-nozzle injection device, so that different tissue scaffold materials and cell / matrix composite materials can be deposited and formed on the forming table. According to the device, accurate formation of a plurality of heterogeneous materials with complex three-dimensional structures can be realized by adopting a fixed multi-nozzle interactive forming mode.

Description

technical field [0001] The invention belongs to the field of tissue engineering, and in particular relates to the design of a three-dimensional controlled forming system of a fixed multi-nozzle complex organ precursor. Background technique [0002] Tissue engineering is a popular interdisciplinary subject at present. Its three major elements are cells, biomaterial scaffolds and growth factors. [0003] Beginning in the middle and late 1990s, advanced manufacturing technology - rapid prototyping technology entered the field of stent forming, which provided a new idea for solving the problems existing in the traditional stent forming technology. Massachusetts Institute of Technology in the United States, Carnegie Mellon University, University of Michigan, National University of Singapore and Tsinghua University in China are all engaged in research work in this area. Among them, some researchers use the existing rapid prototyping process equipment and scaffold materials to fo...

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Problems solved by technology

[0013] ①The rotary disc spraying device has high requirements on the structure. Switching the spray head requires the precise rotation of the rotary disc and high requirements on lubrication and other conditions. At the same time, the number of stepping motors is increased, which increases the cost of the forming machine;

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