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Method for extracting total cyanogenic glycoside from sorbus tianschanica

A technology of Sorbus tianshan and total cyanogenic glycosides, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of serious pollution, low content of total cyanogenic glycosides, unfavorable large-scale production operations, etc. Low consumption, solve the unstable effect

Inactive Publication Date: 2012-01-18
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, the extraction and separation of total cyanogenic glycosides in Sorbus tianshanensis mainly adopts the organic solvent method, etc., but the content of total cyanogenic glycosides obtained by these extraction processes is low, the pollution in the production process is serious, and it is not conducive to large-scale production operations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Grind the dried Sorbus tianshanensis leaves, take 10kg, add 10 times of 50% ethanol solution to soak, squeeze and filter, add activated carbon to the filtrate to keep warm for decolorization, filter, recover ethanol, centrifuge the concentrated solution, add appropriate amount of deionized water to the supernatant, pass through Ultrafiltration with a hollow cellulose ultrafiltration membrane with a molecular weight cut-off of 3000-10000, adsorption on a H-103 macroporous resin column on the permeate, and elution with 30% ethanol solution, collecting the eluate, concentrating under reduced pressure, and spray-drying to obtain the total Cyanogenic glycosides 270g.

Embodiment 2

[0016] Grind the dried Sorbus tianshanensis leaves, take 10kg, add 15 times of 50% ethanol solution to soak, squeeze and filter, add activated carbon to the filtrate to keep warm for decolorization, filter, recover ethanol, centrifuge the concentrated solution, add appropriate amount of deionized water to the supernatant, pass through Ultrafiltration with a hollow cellulose ultrafiltration membrane with a molecular weight cut-off of 3000-10000, adsorption on an AB-8 macroporous resin column on the permeate, and elution with 30% ethanol solution, collecting the eluate, concentrating under reduced pressure, and spray-drying to obtain the total Cyanogenic glycosides 324g.

Embodiment 3

[0018] Grind the dried Sorbus tianshanensis leaves, take 10kg, add 15 times of 50% ethanol solution to soak, squeeze and filter, add activated carbon to the filtrate to keep warm for decolorization, filter, recover ethanol, centrifuge the concentrated solution, add appropriate amount of deionized water to the supernatant, pass through Ultrafiltration with a hollow cellulose ultrafiltration membrane with a molecular weight cut-off of 3000-10000, adsorption on an AB-8 macroporous resin column on the permeate, and elution with 30% ethanol solution, collecting the eluate, concentrating under reduced pressure, and spray-drying to obtain the total Cyanogenic glycosides 409g.

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Abstract

The invention discloses a method for extracting total cyanogenic glycoside from sorbus tianschanica, which comprises the following steps: smashing dried sorbus tianschanica leaves, adding 10-18 times of 50% of ethanol solution to soak, pressing and filtering, adding active carbon in filtrate for heat preservation and decoloration, filtrating, recovering ethanol, carrying out concentrated solution centrifugation, adding proper quantity of deionized water in liquid supernatant, carrying out ultrafiltration through a membrane separation system, carrying out absorption permeate by a macroporous resin column, carrying out elution of 20-35% of ethanol solution, collecting eluent, decompression, and spray drying to obtain total cyanogenic glycoside. The invention has the advantages that process is simple, the operation is simple, the production energy consumption is low, the quality of the obtained product is stable, and the industrial amplification is easily realized.

Description

technical field [0001] The invention relates to a method for extracting total cyanogenic glycosides from Sorbus tianshanensis, in particular to a method for extracting total cyanogenic glycosides from Sorbus tianshanensis by adopting membrane separation and resin column adsorption technology. Background technique [0002] Tianshan Sorbus is a plant of the family Rosaceae, and folks often use its fruit, branches, leaves and stem bark as medicine. Tianshan Sorbus has the effects of clearing the lungs and relieving cough, nourishing the spleen and promoting body fluid. Tianshan Sorbus contains flavonoids, anthocyanins, and cyanogenic glycosides. Pharmacological experiments have shown that the branches and leaves of Tianshan Sorbus have multiple functions such as relieving cough, relieving asthma, and strengthening the heart, and their toxicity is very low. Chen Jian et al. (Chinese Journal of Basic Medicine of Traditional Chinese Medicine, 2001, 7 (1): 45-47) found that the a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61K127/00
Inventor 刘东锋万冬梅
Owner NANJING ZELANG MEDICAL TECH
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