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Method for preparing shenkangning capsules

A technology of Shenkangning capsules and extracts, which is applied in the field of preparation of traditional Chinese medicine preparations, can solve the problems of impossible extraction and great difference in technology, and achieve the effects of increasing the content, shortening the extraction time, and reducing the dosage

Active Publication Date: 2012-01-25
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Traditional Shenkangning Capsules include astragalus, salvia miltiorrhiza, Poria cocos, Alisma, motherwort, Danfu tablets, Cynomorium, yam and other eight medicinal materials. The preparation method is to prepare the extract with water as the solvent. The fat-soluble active ingredients contained in the medicinal materials It is impossible to extract completely with only water as the solvent, and the decoction method is far from the energy-saving and efficient modern pharmaceutical technology

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  • Method for preparing shenkangning capsules

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Experimental program
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Effect test

Embodiment 1

[0014] Astragalus 380g, Motherwort 470g, Cynomorium 320g, Alisma 200g, Danfu Tablet 200g, Salvia miltiorrhiza 110g, Poria cocos 85g, Chinese yam 60g. Bawei herbs were crushed through a 60-mesh sieve, added 14600ml of ethanol with a concentration of 70%, soaked for 120min, and then extracted twice with an ultrasonic extractor at 40kHz, each time for 50min, filtered to obtain the filter residue and extract, and recovered the ethanol from the extract , in a vacuum of 0.95Mpa, concentrated under reduced pressure at 60°C to an extract with a relative density of 1.25 (50°C), to obtain an ethanol extract extract.

[0015] Add 18250ml of water to the dregs extracted by ethanol, extract twice with an ultrasonic extractor at 40kHz at 80°C, each time for 70min, then filter, and concentrate the extract under reduced pressure at 0.95Mpa at a vacuum degree of 0.95Mpa at 60°C to a relative density of 1.25 (50 ℃) extract to obtain water extract extract.

[0016] Dry the mixture of ethanol ex...

Embodiment 2

[0031]Take Astragalus 360g, Motherwort 450g, Cynomorium 300g, Alisma 180g, Danfu Tablet 180g, Salvia miltiorrhiza 100g, Poria cocos 75g, and Chinese yam 50g. Bawei herbs were crushed through a 70-mesh sieve, added 15255ml of ethanol with a concentration of 70%, soaked for 90min, and then extracted twice with an ultrasonic extractor at 35kHz, each time for 40min, filtered to obtain the filter residue and extract, and recovered the ethanol from the extract , in a vacuum of 0.85Mpa, concentrated under reduced pressure at 70°C to an extract with a relative density of 1.20 (50°C), to obtain an ethanol extract extract.

[0032] Add 18645ml of water to the dregs extracted by ethanol, extract twice with an ultrasonic extractor at 35kHz at 70°C, each time for 60min, then filter, and concentrate the extract under reduced pressure at 0.85Mpa at a vacuum of 0.85Mpa at 70°C to a relative density of 1.20 (50 ℃) extract to obtain water extract extract.

[0033] Dry the mixture of ethanol ex...

Embodiment 3

[0043] Take Astragalus 340g, Motherwort 430g, Cynomorium 280g, Alisma 160g, Danfu Tablet 160g, Salvia miltiorrhiza 90g, Poria cocos 65g, and Chinese yam 40g. Bawei herbs are crushed through 80-mesh sieves, added with 15650ml of ethanol with a concentration of 70%, soaked for 90min, then extracted twice with an ultrasonic extractor at 35kHz, each time for 30min, filtered to obtain the filter residue and extract, and recovered the ethanol from the extract , in a vacuum of 0.9Mpa, concentrated under reduced pressure at 50°C to an extract with a relative density of 1.30 (50°C), to obtain an ethanol extract extract.

[0044] Add 18,780ml of water to the dregs extracted by ethanol, extract twice at 35kHz with an ultrasonic extractor at 75°C, 50min each time, and then filter, and concentrate the extract under reduced pressure at a vacuum of 0.9Mpa at 50°C to a relative density of 1.30 (50 ℃) extract to obtain water extract extract.

[0045] Dry the mixture of ethanol extract extract...

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Abstract

The invention relates to a method for preparing shenkangning capsules, which belongs to a preparation method of a Chinese herb preparation and comprises the following steps that: medicinal materials are crushed, sieved and extracted through ultrasonic waves to obtain ethanol extract extractum; medicinal dregs are extracted through ultrasonic waves again to obtain water extract extractum; the ethanol extract extractum and the water extract extractum are mixed and concentrated into thick paste, and compound Chinese herb extracts are obtained through drying; and starch are added for uniform mixing and granulation. The method has the beneficial effects that an ultrasonic wave extraction method is adopted, effective ingredients in medicinal material cells can be fast dissolved out, in addition, the destruction to the effective ingredients of the medicinal materials under the severe conditions of heating, decoction and the like is omitted, and the advantages of high effective ingredient extraction rate, short extraction time, energy saving, environment protection and the like are reached.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a preparation method of traditional Chinese medicine preparations. Background technique [0002] Shenkangning Capsule is a classic medicine that has the effects of warming the kidney, replenishing qi, promoting blood circulation, and expelling dampness. Chinese patent medicine. Traditional Shenkangning Capsules include astragalus, salvia miltiorrhiza, poria cocos, alisma, motherwort, Danfu tablets, Cynomorium, yam and other eight medicinal materials. The preparation method is to prepare the extract with water as the solvent. The fat-soluble active ingredients contained in the medicinal materials It is impossible to extract completely only with water as a solvent, and the decoction method is far from the energy-saving and efficient modern pharmaceutical technology. Contents of the invention [0003] The object of the present invention is to ...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P13/12
Inventor 肖军平郭峰吴永忠李旭胡绍钧
Owner JIANGXI POZIN PHARMA
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