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Low-toxicity panax notoginseng saponins injection and preparation method thereof

A technology of Panax notoginseng saponins and glycoside injections, which is applied in the field of medical inventions, can solve the problems of adverse reactions, risks, and high adverse reactions, and achieve the effects of reducing toxicity, reducing the rate of clinical adverse reactions, and improving hemolysis and coagulation indicators

Inactive Publication Date: 2012-02-01
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that the risks and adverse reactions of Panax notoginseng saponins injection are very high among the types of injections
[0019] Moreover, although the removal methods of impurities are constantly being followed up, and the purity of the extract is getting higher and higher, the adverse reactions of Panax notoginseng saponins injection are still unavoidable
[0020] As a complex component of traditional Chinese medicine, adverse reactions cannot be avoided even if the content of impurities is small. The reason is that there are other substances in the injection that cannot be detected by current means, which lead to the occurrence of adverse reactions

Method used

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  • Low-toxicity panax notoginseng saponins injection and preparation method thereof
  • Low-toxicity panax notoginseng saponins injection and preparation method thereof
  • Low-toxicity panax notoginseng saponins injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Embodiment 1: Panax notoginseng total saponins freeze-dried powder injection (first method)

[0076] 1. Extraction method:

[0077] Take the main root of Panax notoginseng, make 10 mesh coarse powder, extract 5 times with ethanol, add 2 times of 50% ethanol each time, extract 5 hours each time, combine the extracts, filter, recover the ethanol from the filtrate until it has no alcohol smell, add water Make each 1ml contains about 1g of crude drug, stir well, let stand for 36 hours, filter;

[0078] The filtrate is adjusted to a pH value of 7.0, and the macroporous weakly acidic rosin-based cation exchange resin column passing through 10 times the weight of Panax notoginseng with a flow rate of 15BV / h is used to collect the effluent; The macroporous resin column is eluted successively with ethanol solutions with a concentration of 10-80% (the ethanol concentrations of sequential elution are respectively 10, 45, 50, 55, 80), and the qualified parts are collected (on-line...

Embodiment 2

[0097] Embodiment 2: Panax notoginseng total saponins freeze-dried powder injection (second method)

[0098] 1. Extraction method:

[0099] Take notoginseng main root, make 40 mesh coarse powder, extract with ethanol twice, add 12 times of 60% ethanol each time, extract for 2 hours each time, combine the extracts, filter, take the filtrate to recover ethanol until it has no alcohol smell, Concentrate under reduced pressure to contain about 0.5g of crude drug per 1ml, add sodium chloride to make the concentration of sodium chloride reach 0.05%, stir well, let stand, and filter;

[0100] Get the filtrate and add 0.1% sodium citrate, pass through a macroporous weakly acidic rosin-based cation exchange resin column with 0.1 times the weight of Panax notoginseng, and the flow rate is 0.5BV / h, collect the effluent; Pore ​​adsorption resin column adsorption; use 1BV, 0.1% sodium hydroxide solution to elute at a flow rate of 0.5BV / h, and discard the eluent; wash the column with purif...

Embodiment 3

[0109] Embodiment 3: the extraction method of Panax notoginseng total saponins (the first method)

[0110] 1. Extraction method:

[0111] Take the main root of Panax notoginseng, make 20 mesh coarse powder, extract twice with ethanol, add 20 times of 80% ethanol each time, each time for 1 hour, combine the extracts, filter, recover the ethanol from the filtrate until it has no alcohol smell, add water to prepare Each 1ml contains about 0.5g of crude drug, stir well, let stand for 12 hours, and filter;

[0112] The filtrate is adjusted to a pH value of 7.5, and the macroporous weakly acidic rosin-based cation exchange resin column with a flow rate of 0.5 BV / h passes through 0.1 times the weight of Panax notoginseng, collects the effluent, and passes through 0.5 times the weight of Panax notoginseng with a flow rate of The macroporous resin column is eluted successively with ethanol solutions with a concentration of 10-80% (the ethanol concentrations of sequential elution are r...

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Abstract

The invention relates to a low-toxicity panax notoginseng saponins injection and a preparation method thereof. The injection comprises the following components in percentage by weight: 9.5-15.0% of notoginsenoside, 37.0-56.0% of ginsenoside Rg1, 5.0-8.0 of ginsenoside Re5, 21.0-32.0% of ginsenoside Rb1, and not less than 1.0% of ginsenoside Rd. The panax notoginseng saponins provided by the invention has low toxicity, and less adverse reactions.

Description

technical field [0001] The invention relates to the field of medical inventions, in particular to a low-toxicity Panax notoginseng saponin injection capable of treating diseases such as cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] Panax notoginseng saponins are a commonly used medicine for the treatment of cardiovascular and cerebrovascular diseases in clinical practice. The injection preparations of Panax notoginseng total saponins currently used for the treatment of cardiovascular and cerebrovascular diseases include: Xueshuantong injection, Xueshuantong for injection, Xuesaitong injection, Xuesaitong for injection. [0003] On June 13, 2011, the quality standards of Panax notoginseng saponins were publicized in the "Publicity of the Draft Standards of Essential Drugs of Traditional Chinese Medicine (Fifth Batch)". The regulations are as follows: [0004] [0005] It can be seen from the above table: [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K9/08A61K9/14A61K9/19A61P9/00
Inventor 许淑清黄宇声刘冠萍张栩颜李钊文吴垣墙陈小杰
Owner GUANGXI WUZHOU PHARMA GRP