Lactucin derivative, and preparation method and application thereof
A technology of leucanthemum and derivatives, which is applied in the field of natural medicine and medicinal chemistry, can solve the problems of single structure, low toxicity and side effects, and small quantity, and achieves the effects of simple experimental steps and mild reaction conditions.
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Embodiment 1
[0030] Embodiment 1: the preparation of derivative 1
[0031] Add 50mg (0.18mmol) lactuca into 1.0ml pyridine, and slowly add 18mg (0.18mmol) acetic anhydride dropwise under cooling in an ice-water bath. After the reaction was completed, the reaction solution was separated by column chromatography to obtain raptudin monoacetate 1.
Embodiment 2
[0032] Embodiment 2: the preparation of derivative 2
[0033] Add 50mg (0.18mmol) lactuca into 1.0ml pyridine, and slowly add 36mg (0.36mmol) acetic anhydride dropwise under cooling in an ice-water bath. After the reaction was completed, the reaction solution was separated by column chromatography to obtain raptudin diacetate 2.
Embodiment 3
[0034] Embodiment 3: the preparation of derivative 3
[0035] Add 50mg (0.18mmol) of Lactuca into 1.0ml of pyridine, and slowly add 25mg (0.18mmol) of benzoyl chloride dropwise under cooling in an ice-water bath. After the reaction was completed, the reaction solution was separated by column chromatography to obtain raptudin monobenzoate 3.
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