Hydroxyapatite, sodium hyaluronate and konjac glucomannan composite material and preparation method thereof

A technology of konjac glucomannan and sodium hyaluronate, which is applied in the field of biomedical materials, can solve problems such as poor mechanical properties, limited application, and high brittleness, and achieve the effects of meeting requirements, improving mechanical properties, and promoting bone growth

Active Publication Date: 2012-03-21
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its poor mechanical properties, low strength and high brittleness limit its clinical application in medicine.

Method used

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  • Hydroxyapatite, sodium hyaluronate and konjac glucomannan composite material and preparation method thereof
  • Hydroxyapatite, sodium hyaluronate and konjac glucomannan composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: see figure 1 , the preparation method of this hydroxyapatite, sodium hyaluronate and konjac glucomannan composite material is:

[0027] (1) According to the mass ratio of sodium hyaluronate and water of 1:2000, dissolve sodium hyaluronate in water, stir it to fully dissolve, and then add alkaline solution into the solution; the concentration of alkaline solution is 0.1vol % NH 3 ·H 2 O solution, the volume ratio of alkaline solution to water is 1:800.

[0028] (2) Cross-linking: According to the mass ratio of sodium hyaluronate to konjac glucomannan of 1:8, konjac glucomannan was added to the product obtained in step (1), and stirred until it was in a gel state.

[0029] (3) Seal the product obtained in step (2) and mature it in a water bath at a temperature of 90°C for 12 hours, take out the product, and then lower the temperature of the water bath to 15°C, then place the product in a water bath to dealkalize until the product solution The pH value was 7...

Embodiment 2

[0033] Example 2: see figure 1 , the preparation method of this hydroxyapatite, sodium hyaluronate and konjac glucomannan composite material is:

[0034] (1) According to the mass ratio of sodium hyaluronate to water is 1:667, dissolve sodium hyaluronate in water, stir to make it fully dissolved, and then add alkaline solution into the solution; the concentration of alkaline solution is 0.8vol % NH 3 ·H 2 O, the amount added is 1:500 according to the volume ratio of alkaline solution and water.

[0035] (2) Crosslinking: According to the mass ratio of sodium hyaluronate to konjac glucomannan of 1:25, konjac glucomannan was added to the product obtained in step (1), and stirred until it was in a gel state.

[0036] (3) Seal the product obtained in step (2) and mature it in a water bath at a temperature of 70°C for 24 hours, take out the product, and then lower the temperature of the water bath to 30°C, then place the product in a water bath to dealkalize until the product so...

Embodiment 3

[0041] Embodiment 3: see figure 1 , the preparation method of this hydroxyapatite, sodium hyaluronate and konjac glucomannan composite material is:

[0042] (1) According to the mass ratio of sodium hyaluronate and water of 1:400, dissolve sodium hyaluronate in water, stir to fully dissolve, and then add alkaline solution into the solution; the concentration of alkaline solution is 1vol% NaOH solution, the amount added is 1:80 according to the volume ratio of alkaline solution to water.

[0043] (2) Cross-linking: According to the mass ratio of sodium hyaluronate to konjac glucomannan of 1:200, konjac glucomannan was added to the product obtained in step (1), and stirred until it was in a gel state.

[0044] (3) Seal the product obtained in step (2) and mature it in a water bath at a temperature of 50°C for 48 hours, take out the product, then lower the temperature of the water bath to 50°C, and put the product in a water bath to dealkalize until the product solution The pH ...

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Abstract

The invention relates to a hydroxyapatite, sodium hyaluronate and konjac glucomannan porous scaffold composite material for bone defect restoration and a preparation method thereof, and belongs to the field of biomedical materials. The preparation method comprises the following steps of: cross-linking sodium hyaluronate and konjac glucomannan serving as raw materials to obtain a sodium hyaluronate and konjac glucomannan porous scaffold material, and preparing a hydroxyapatite, sodium hyaluronate and konjac glucomannan porous scaffold material by a pre-calcification and simulated body fluid (SBF) solution soaking bionic mineralization method. Reaction conditions are mild, the used materials are safe, non-toxic and low in cost, and the preparation process is simple; meanwhile, the scaffold material has high mechanical properties and a unique three-dimensional structure and meets the requirement of bone tissue engineering.

Description

technical field [0001] The invention relates to a composite material of hydroxyapatite, sodium hyaluronate and konjac glucomannan and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] The repair of bone defects has been a key topic of continuous in-depth research for centuries. With the continuous progress of biomedicine and tissue engineering research, the research on tissue engineering scaffold materials has attracted the attention of researchers. At present, hydroxyapatite (Hydroxyapatite, HAP), as the main inorganic component of human and animal bones and teeth, has good biological activity and biocompatibility, and is considered to be the most potential human hard tissue replacement material. However, its poor mechanical properties, low strength and high brittleness limit its clinical application in medicine. In order to get closer to the mechanical requirements of human bones, people try to introduce other subs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/56C08J9/40
Inventor 陈庆华王静陈佳黄明华
Owner KUNMING UNIV OF SCI & TECH
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