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Myocardial small molecular compound for idiosyncratically promoting proliferation of myocardial cells and application thereof

A technology of small molecular compounds and cardiomyocytes, applied in the field of medicine, can solve the problems of limited use and limited capacity of multifunctional stem cells

Inactive Publication Date: 2012-03-21
FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to ethical issues and tumorigenic potential, the use of pluripotent stem cells has been greatly limited, and recent experiments have shown that stem cells as donors have limited ability to differentiate into cardiomyocytes and have only moderate clinical therapeutic effects

Method used

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  • Myocardial small molecular compound for idiosyncratically promoting proliferation of myocardial cells and application thereof
  • Myocardial small molecular compound for idiosyncratically promoting proliferation of myocardial cells and application thereof
  • Myocardial small molecular compound for idiosyncratically promoting proliferation of myocardial cells and application thereof

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Embodiment Construction

[0018] The present invention is described in further detail below.

[0019] 1. Large-scale screening of active small molecule compounds through the model organism zebrafish.

[0020] Zebrafish, as a model organism, plays a very important role in multiple steps in the drug discovery process. The zebrafish is rapidly gaining acceptance as a promising animal model in toxicology research, and the ability to efficiently assess the toxicity of large numbers of compounds could allow entire compound libraries to be pre-screened for potential toxicity in advance. With this approach, compounds with significant toxicity can be eliminated from the compound library prior to high-throughput screening. Therefore, the screening of small molecular compounds based on embryo research in the present invention is carried out in the model organism zebrafish, and the small molecular compounds that can regulate the development and differentiation of embryos and organs are screened from the small mol...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a myocardial small molecular compound for idiosyncratically promoting proliferation of myocardial cells and application thereof. The myocardial small molecular compound total comprises a type A, a type B and a type C which have a common core structure, namely (3 (1, 2, 4) triazole (3, 4-b) (1, 3, 4) bismuththiol). The myocardial small molecular compound is obtained from a small molecular compound library by means of model organism zebra fish screening, so as to be capable of idiosyncratically promoting proliferation of myocardial cells inside zebra fish bodies. Importantly, the myocardial small molecular compound is capable of inducing embryonic stem cells of a small mouse to differentiate and proliferate towards the myocardial cells. As proved, the myocardial small molecular compounds are antagonists to inhibit wnt signaling pathways. The myocardial small molecular compound can be used as pilot drugs for treating heart diseases and further is used for optimizing and evaluating candidate drug targets thereof.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to the relationship between exogenous small molecule compounds and cardiomyocytes, which is related to the treatment of heart diseases. Background technique [0002] Cardiovascular disease is the most common disease that endangers human health, and its morbidity and mortality have surpassed malignant tumors and ranked first. Despite the continuous progress of modern medicine, the treatment of ischemic heart disease such as myocardial infarction and heart failure is still facing great challenges. The development of therapeutic methods that can stimulate myocardial cell regeneration in the myocardial infarction area to increase the number of myocardial cells has great clinical significance. medical prospects and economic benefits. In recent years, with the emergence and development of stem cell technology, stem cell therapy provides the possibility for the treatment of is...

Claims

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Application Information

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IPC IPC(8): C07D513/04A61K31/433A61K31/4439A61P9/00
Inventor 钟涛
Owner FUDAN UNIV
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