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Absorbable operating suture line and preparation method thereof

A surgical suture, absorbent technology, used in surgery, medical science, textiles and papermaking, etc., can solve the high tensile strength requirements of chitosan sutures, which are difficult to meet actual clinical needs, and the cross-section of sutures. Insufficient roundness and other problems to achieve the effect of meeting clinical needs, improving operability, and low grayscale

Inactive Publication Date: 2012-04-11
司忠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The chitosan suture prepared by this process is cut into strips and then drawn, resulting in insufficient roundness of the cross section of the suture, which increases the friction resistance during use and brings inconvenience to the actual operation. ; and the requirement for the tensile strength of chitosan suture is high, it is difficult to meet the actual clinical needs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation of spinning solution: Dissolve 3.5 wt% chitosan in 3.5 wt% acetic acid solution, then add 0.5 wt% urea and 1.5 wt% glycerin, and stir to obtain a chitosan solution. Filter through a 1000-mesh filter cloth under 2 atmospheric pressures to remove insoluble matter, and then remove air bubbles under vacuum conditions for 24 hours to obtain a spinning solution;

[0024] Spinning: the spinning solution obtained above is input to the spinneret with 0.08mm aperture and 30 holes with a metering pump, so that the spinning solution is squeezed into the coagulation bath, and the preparation of this coagulation bath solution is 5wt% sodium hydroxide and The mass ratio of 95wt% medical ethanol is 9:1, the temperature of the spinning solution squeezed into the coagulation bath is controlled at 15°C to 20°C, and stretched while coagulating. The stretching ratio of the silk thread is 1 times, and the chitosan thread is obtained. ;

[0025] Subsequent treatment: After the ...

Embodiment 2

[0027] Preparation of spinning solution: Dissolve 4.5 wt% chitosan in 5 wt% acetic acid solution, then add 1.2 wt% urea and 2.5 wt% glycerin, and stir to obtain a chitosan solution. Filter through a 1000-mesh filter cloth under 2 atmospheric pressure, filter out insoluble matter, and then remove air bubbles under vacuum conditions for 24 hours to cool down to obtain a spinning solution;

[0028] Spinning: the above-mentioned obtained spinning solution is input to the spinneret with 0.08mm aperture and 30 holes with a metering pump, so that the spinning solution is squeezed into the coagulation bath, and the preparation of this coagulation bath solution is 14wt% sodium hydroxide and The mass ratio of 95wt% medical ethanol is 9:1, the temperature of the spinning solution squeezed into the coagulation bath is controlled at 15°C to 20°C, and stretched while solidifying. The stretching ratio of the thread is 1.4 times, and the chitosan thread is obtained. ;

[0029] Subsequent t...

Embodiment 3

[0031] Preparation of spinning solution: Dissolve 7.5 wt% chitosan in 7.5 wt% acetic acid solution, then add 1.5 wt% urea and 3.5 wt% glycerin, and stir to obtain a chitosan solution. Filter through a 1000-mesh filter cloth under 2 atmospheric pressure, filter out insoluble matter, and then remove air bubbles under vacuum conditions for 24 hours to cool down to obtain a spinning solution;

[0032] Spinning: the above-mentioned obtained spinning solution is input to the spinneret with 0.08mm aperture and 30 holes with a metering pump, and the spinning solution is squeezed into the coagulation bath. The preparation of this coagulation bath solution is 20wt% sodium hydroxide and The mass ratio of 95wt% medical ethanol is 9:1, the temperature of the spinning solution squeezed into the coagulation bath is controlled at 15°C to 20°C, and stretched while coagulating. The stretching ratio of the silk thread is 2 times, and the chitosan thread is obtained. ;

[0033] Subsequent tre...

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Abstract

The invention discloses an absorbable operating suture line and a preparation method thereof, and mainly relates to a chitosan operating suture line. The preparation process comprises the following steps of: preparing a chitosan spinning solution, spinning, solidifying, performing subsequent treatment, and the like. By the process, chitosan is subjected to wet spinning, so that the roundness of the cross section of the chitosan operating suture line is increased, and the operability of the suture line is improved; and the suture line prepared by the process has high tensile strength and elasticity and meets the clinical requirement.

Description

technical field [0001] The invention relates to a surgical suture and a preparation method thereof, in particular to an absorbable surgical suture, in particular to an absorbable surgical suture prepared with chitosan. Background technique [0002] Medical surgical suture is a kind of wound healing, tissue ligation and tissue fixation, which plays an important role in the initial healing of wounds. Generally, it can be divided into two categories: absorbable sutures and non-absorbable sutures. Non-absorbable sutures do not degrade in the body. It is degraded by acid, alkali or enzyme. The degradation rate depends on the temperature, PH value of the tissue and the liquid environment around the suture. [0003] Chitosan is an alkaline polysaccharide containing free amino groups, which can be dissolved in mineral acid, organic acid and weak acid dilute solution to form a viscous colloid, because the molecule also has -OH, -NH 2 Polar gene, so it has better hygroscopicity, moi...

Claims

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Application Information

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IPC IPC(8): A61L17/10D01F9/00
Inventor 司忠
Owner 司忠
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