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Production process of multienzyme pieces

A production process and technology of multi-enzyme tablets, applied in the field of medicine, can solve problems such as inability to guarantee product quality, achieve ideal results and reduce the effect of increasing the amount of feeding

Active Publication Date: 2013-08-07
重庆申高生化制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Even so, there is no guarantee of product quality

Method used

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  • Production process of multienzyme pieces

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] a. Remove the outer packaging of raw and auxiliary materials: Weigh 41.25kg of pancreatin, 5.50kg of pepsin, 18.50kg of sucrose, grind through a 100-mesh sieve, 40.00kg of sucrose, 1.10kg of dextrin, 0.40kg of magnesium stearate, 120.70kg of talcum powder, 0.10kg gelatin, 2.25kg polyacrylic resin, 20.00kg ethanol, 8.50kg starch, 0.75 bottle of diethyl phthalate, 0.75 bottle of Tween-80, 0.15 bottle of castor oil, 0.20 kg of carmine, 0.01 kg of red cabbage , rice core wax 0.10 kg, use 75% ethanol to disinfect the surface of the inner bag for later use;

[0019] b. Buffer;

[0020] c. Crushing and pretreatment of raw and auxiliary materials;

[0021] d. Weighing, batching and mixing;

[0022] e. Granulation, drying, granulation, and total blending;

[0023] f, granule transfer, tablet compression, substrate outer coating pressed after pancreatin and blank granules are mixed, when the polyacrylate layer is separated between pancreatin and pepsin, the original amount of ...

Embodiment 2

[0026] a. Remove the outer packaging of raw and auxiliary materials: Weigh 41.25kg of pancreatin, 5.50kg of pepsin, 18.50kg of sucrose, grind through a 100-mesh sieve, 40.00kg of sucrose, 1.10kg of dextrin, 0.40kg of magnesium stearate, 120.70kg of talcum powder, 0.10kg gelatin, 2.25kg polyacrylic resin, 20.00kg ethanol, 8.50kg starch, 0.75 bottle of diethyl phthalate, 0.75 bottle of Tween-80, 0.15 bottle of castor oil, 0.20 kg of carmine, 0.01 kg of red cabbage , rice core wax 0.10 kg, use 75% ethanol to disinfect the surface of the inner bag for later use;

[0027] b. Buffer;

[0028] c. Crushing and pretreatment of raw and auxiliary materials;

[0029] d. Weighing, batching and mixing;

[0030] e. Granulation, drying, granulation, and total blending;

[0031] f, granule transfer, tablet compression, substrate outer coating pressed after pancreatin and blank granules are mixed, when the polyacrylate layer is separated between pancreatin and pepsin, the original amount of ...

Embodiment 3

[0034] a. Remove the outer packaging of raw and auxiliary materials: Weigh 41.25kg of pancreatin, 5.50kg of pepsin, 18.50kg of sucrose, grind through a 100-mesh sieve, 40.00kg of sucrose, 1.10kg of dextrin, 0.40kg of magnesium stearate, 120.70kg of talcum powder, 0.10kg gelatin, 2.25kg polyacrylic resin, 20.00kg ethanol, 8.50kg starch, 0.75 bottle of diethyl phthalate, 0.75 bottle of Tween-80, 0.15 bottle of castor oil, 0.20 kg of carmine, 0.01 kg of red cabbage , rice core wax 0.10 kg, use 75% ethanol to disinfect the surface of the inner bag for later use;

[0035] b. Buffer;

[0036] c. Crushing and pretreatment of raw and auxiliary materials;

[0037] d. Weighing, batching and mixing;

[0038] e. Granulation, drying, granulation, and total blending;

[0039] f, granule transfer, tabletting, substrate outer coating pressed after pancreatin and blank granules are mixed, when the polyacrylate layer is separated between pancreatin and pepsin, the original amount of polyacr...

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Abstract

The invention relates to a production process of multienzyme pieces. In the traditional single-layer coating process, a polyacrylate layer is adopted for separation between pancreatin and pepsase, so that the feeding amount of the pancreatin and the pepsase is generally increased by 30-50%, but the quality of a product can not be ensured either. The production process is characterized in that in the outer coating section of a base piece, solution obtained by adding alcohol into the single polyacrylic resin layer coated outside the original base piece with the amount being 8-10 times that of the polyacrylic resin is changed into three layers of polyacrylic resin with different pH values for coating, and after drying, a pepsase layer is coated, so that the three layers of polyacrylic resin with different pH values are separated between the pancreatin and the pepsase, the problem of respective protection of the pancreatin and the pepsase is solved, further the effective period is prolonged from 12 months to 18 months, and the feeding amount is greatly reduced.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a production process of multi-enzyme tablets. Background technique [0002] Multi-enzyme tablet is a compound preparation composed of two enzymes, trypsin and pepsin. Among them, trypsin is a mixed enzyme, which mainly contains trypsin, amylase and lipase, and pepsin is a single enzyme. The production of multi-enzyme tablets is to mix pancreatin granules and blank granules made of sucrose evenly, press the substrate with a tablet press, add 48-55kg of substrate to the coating machine, and turn the coating machine to the temperature of the substrate. When it reaches about 30°C, enteric coating (polyacrylic acid resin layer) is applied. After the enteric coating is completed and dried, it is then coated with pepsin layer, and finally coated with sugar to become a medicine. After the multi-enzyme tablet is taken, the sugar-coated layer disintegrates and dissolves rapidly in the gastric jui...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/48A61K38/43
Inventor 龚志国
Owner 重庆申高生化制药股份有限公司
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