Vinpocetine special-purpose crystallization pot

Abstract

The invention relates to a vinpocetine special-purpose crystallization pot, which contains a pot rack, a pot and a stirring device. The pot contains a pot body and a cover. The bottom of the pot body is provided with a discharge hatch which is equipped with a discharged valve. A feed inlet is disposed on the cover. The periphery of the pot body is provided with an insulation jacket with a steam inlet and a condensed water outlet. The crystallization pot also contains a condensation coil pipe disposed inside the pot body. The condensation coil pipe is equipped with a condensate liquid inlet and a condensate liquid outlet which extend out through the pot. According to the crystallization pot, the condensation coil pipe is arranged inside the pot. As the condensation coil pipe directly contacts with a material, the heat transfer efficiency is highest, and the material can be rapidly cooled. Therefore, the vinpocetine crystallization rate can be raised and the crystallization efficiency can be improved. In addition, the invention is simple to arrange and convenient to operate.

Description

technical field [0001] The invention relates to a special crystallization tank for vinpocetine. Background technique [0002] Vinpocetine, a derivative of the alkaloid vincamine, exhibits activity on neuronal metabolism by aiding aerobic glycolysis and promoting redistribution of blood flow to ischemic areas. Vinpocetine has also been reported to increase cerebral circulation and oxygen utilization. Vinpocetine is commonly used to help improve memory and can help fight symptoms of Alzheimer's. [0003] At present, the synthesis of vinpocetine by chemical methods generally requires recrystallization to improve product purity. The main process of recrystallization is to choose a solvent (usually ethanol) that can dissolve both vinpocetine and impurities to dissolve the crude product, and then reduce the temperature to precipitate vinpocetine crystals. Generally speaking, in order to achieve the complete dissolution of the crude product, the system is generally heated to 50 ...

AI Technical Summary

Problems solved by technology

Traditional crystallization tanks used in dairy industry, food, chemical industry, beverage and other industries include a tank frame, a tank body set on the tank frame, a stirring device and a jacket set on the periphery of the tank body, wherein the bottom of the tank body is opened with a discharge It can release the precipitated crystals, heat the tank body through hot water or steam in the jacket, or cool down the tank body through condensed water. The two functions cannot be used together.

When adopting such a crystallization tank to carry out the crystallization of vinpocetine, the following problems will occur: in order to make the vinpocetine crude product dissolve completely, the tank body must be heated to the requirement by heating steam or hot water through the jacket. After the crude product is completely dissolved, the material in the tank can only be cooled by natural cooling, which takes a long time, the crystallization rate is poor, and the product yield is low

Assuming that another container will be used to dissolve the vinpocetine crude product completely, then the solution is transferred to the tank body of the crystallization tank, and the cooling water in the jacket is used to reach the low temperature required for crystallization. Although the crystallization rate of this method is higher than that of the former Slightly higher, but the operation is very troublesome, and it is actually equivalent to using two sets of equipment, because at least another heating device and stirring device are installed in another container. In addition, jacket cooling is used to cool the material in the tank very slowly. , the crystallization rate is not high, and the efficiency is also low

Images