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Application of Opuntia ficus-indica Milpa Alta polysaccharides to prevention and treatment of chronic neurodegenerative disease

A technology of cactus polysaccharides and cactus, applied in the field of medicine, can solve problems such as ineffectiveness

Inactive Publication Date: 2012-05-02
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some research results are still confusing, such as the same antioxidant animal experiments are effective, but clinical trials are often ineffective

Method used

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  • Application of Opuntia ficus-indica Milpa Alta polysaccharides to prevention and treatment of chronic neurodegenerative disease
  • Application of Opuntia ficus-indica Milpa Alta polysaccharides to prevention and treatment of chronic neurodegenerative disease
  • Application of Opuntia ficus-indica Milpa Alta polysaccharides to prevention and treatment of chronic neurodegenerative disease

Examples

Experimental program
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Embodiment 1

[0075] Example 1 Extraction, separation and purification of cactus polysaccharides

[0076] Source of medicinal materials: Mibangta edible cactus is purchased from the planting base in Henan Province and purchased fresh. Main reagents: cellulose DEAE-52 (Whatman Company); absolute ethanol, 95% ethanol, acetone, diethyl ether, concentrated sulfuric acid, and phenol are all analytically pure domestically available commercially. Main instruments: constant temperature water bath, vacuum drying oven, electronic balance, rotary evaporator, ultraviolet spectrophotometer.

[0077] Preparation of crude polysaccharides from cactus Mibangta: freshly purchased stems of cactus Mibangta were washed, peeled, cut into pieces, and dried. Take the dry mibangta cactus stem fragments and filter them with double distilled water at 0.1:1 (ratio of weight to volume, i.e. 1 kg of substance: 1 liter of solvent water) at 95°C for 3 h, remove the filtrate, and add 2 times of Stir in double-distilled w...

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Abstract

The invention discloses application of Opuntia ficus-indica Milpa Alta polysaccharides to the prevention and treatment of chronic neurodegenerative disease. The Opuntia ficus-indica Milpa Alta polysaccharides can improve the neurobehavioral disorder of rats, reduce the volume and cortices of cerebral infarction and the loss of hippocampal neurons, can reduce reactive oxygen species (ROS) in cells, has a good neuroprotection effect, can be taken as a medicine for preventing and treating chronic neurodegenerative disease of a central nervous system, and is used for preventing and treating chronic neurodegenerative disease of the central nervous system. The invention also provides an optimized process for extracting the Opuntia ficus-indica Milpa Alta polysaccharides. The extraction process has the characteristics of high polysaccharide yield and the like, is convenient, simple, economical and applicable, and is suitable for large-batch extraction.

Description

technical field [0001] The invention belongs to the field of medicine and relates to medicines for preventing and treating chronic neurodegenerative diseases of the central nervous system. . Background technique [0002] A variety of chronic diseases of the central nervous system in humans, such as cerebral ischemia, epilepsy, Parkinson's disease, senile dementia, etc., the main pathological changes are damage, loss, necrosis and apoptosis of nerve cells. Recently, more and more studies have proved that the ultimate cause of nerve cell damage is oxidative stress (OS). The so-called oxidative stress is a large amount of reactive oxygen species (reactive oxygen species, ROS) exceeds the ability of the body's antioxidant defense system to scavenge oxygen free radicals, and eventually the imbalance between the oxidation system and the antioxidant system leads to tissue damage. Oxidative damage to cellular DNA caused by free radicals triggers apoptosis. Because the nervous sys...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61P25/28A61P25/16A61P9/10
Inventor 郭莲军陈扬陈建国黄先菊湛进进赵博徐旭林吕青
Owner HUAZHONG UNIV OF SCI & TECH
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