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A method for preparation of enantioselective composite membrane

An enantioselective, composite membrane technology, applied in the field of preparation of enantioselective composite nanofiltration membranes, can solve the problem of selectivity decline

Inactive Publication Date: 2012-05-02
COUNCIL OF SCI & IND RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These membranes have high mechanical properties, but the membranes immobilized in the polymer matrix become rapidly saturated at the permeation recognition sites, resulting in a sharp decline in the selectivity of such membranes over time.

Method used

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  • A method for preparation of enantioselective composite membrane

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Embodiment 1

[0053] The preparation method of the enantioselective composite membrane comprises: immersing the polysulfone UF membrane in the aqueous solution of 1% arginine and piperazine (Piprazine) (50:50) for 3 minutes, and keeping the solution by adding 1N NaOH pH 12, excess solution was drained for 15 min, membrane was then immersed in 0.5% trimesoyl chloride in hexane for 2 min, excess solution was drained for 2 min, and membrane was air dried for 4 Hour. The films were heat cured at a temperature of 90°C for 5 minutes, cooled to a temperature of 25°C, air dried for 2 hours, and soaked in deionized water for up to 24 hours. The separation and enantioselectivity of the membranes for arginine were tested under standard conditions: 0.1% aqueous solution of racemic arginine was used as feed at a flow rate of 500 ml per minute at 552 KPa. The membrane exhibited a permeation rate of 636 l / m 2 / day, the arginine rejection (rejection) was 75%, and the enantioselectivity to d-arginine was ...

Embodiment 2

[0055]The preparation method of the enantioselective composite membrane comprises: immersing the polysulfone UF membrane in the aqueous solution of 1% arginine and piperazine (50:50) for 3 minutes, and maintaining the pH of the aqueous solution at 12 by adding 1N NaOH , the excess solution was drained over 15 minutes, the membrane was then immersed in 1% trimesoyl chloride in hexane for 2 minutes, the excess solution was drained over 5 minutes, and the membrane was air dried for 4 hours. The films were heat cured at a temperature of 90°C for 5 minutes, cooled to a temperature of 25°C, air dried for 2 hours, and soaked in deionized water for up to 24 hours. The separation and enantioselectivity of the membrane for arginine were tested under standard conditions: 0.1% aqueous solution of racemic arginine was used as feed, the flow rate was 500 ml per minute at 552 KPa. After 6 hours the membrane exhibited a permeation rate of 734 l / m 2 / day, the arginine rejection rate was 66%, ...

Embodiment 3

[0057] The preparation method of the enantioselective composite membrane comprises: immersing the polysulfone UF membrane in 1% piperazine aqueous solution for 3 minutes, maintaining the pH of the aqueous solution at 12 by adding 1N NaOH, draining off the excess solution for 15 minutes, The membrane was then dipped in a 0.5% solution of trimesoyl chloride in hexane for 2 minutes, the excess solution was drained over 5 minutes, and the membrane was air dried for 4 hours. The films were heat cured at a temperature of 90°C for 5 minutes, cooled to a temperature of 25°C, air dried for 2 hours, and soaked in deionized water for up to 24 hours. The membrane was tested under standard conditions: 0.1% aqueous solution of racemic arginine was used as feed, the flow rate was 500 ml per minute at 552 KPa. The membrane exhibited a permeation rate of 1125 l / m 2 / day, the arginine retention rate was 60%. The membrane showed no enantioselectivity for d-arginine.

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Abstract

The present invention provides an enantioselective composite membrane useful for separation of optical isomers and the process for the preparation thereof. The invention further provides a membrane based pressure driven separation process for separation of enantiomers from their mixture to obtain optical pure isomers. The present invention also provides a membrane based method for optical resolution of racemic mixtures of amino acids to obtain optically pure amino acids.

Description

field of invention [0001] The present invention relates to a process for the preparation of enantioselective composite membranes for the separation of amino acids from their aqueous solutions and for the optical resolution of racemic mixtures. The invention particularly relates to a preparation method of an enantioselective composite nanofiltration membrane, and the enantioselective composite nanofiltration membrane is used for the separation of optical isomers of amino acids. [0002] The enantioselective composite membrane of the present invention is used to separate enantiomers from a mixture of enantiomers to obtain optically pure isomers. The enantioselective composite membrane of the present invention can be used to optically resolve racemic mixtures of amino acids and chiral compounds in pressure-driven membrane processes such as reverse osmosis and nanofiltration to obtain optically pure enantiomers. Background of the invention [0003] Stereoisomers are those molec...

Claims

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Application Information

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IPC IPC(8): B01D69/02B01D69/12B01D71/56C07C227/34
CPCB01D69/02B01D71/56B01D69/125C07C227/34B01D61/007C07C277/06C07C229/26C07C279/14B01D67/0002B01D69/1251
Inventor 克日帕尔·辛格哈里·昌德·巴贾杰帕尔文·加内施劳·英戈尔
Owner COUNCIL OF SCI & IND RES
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