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Compound containing carbon or oxygen isotope and preparation method thereof and application thereof and composition thereof

A technology for oxygen isotopes and oxygen compounds, which can be applied to the introduction of isotopes into organic compounds, compounds of Group 5/15 elements of the periodic table, preparation of sugar derivatives, etc. Low pollution, short half-life effects

Inactive Publication Date: 2012-05-16
BEIJING TOP GRADE HEALTHCARE MEDICAL EQUIP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, containing [ 18 The labeled compound of F] is expensive in terms of production cost, and can only be limited to some limited compounds, that is, only certain groups in the compound can be labeled after being replaced by fluorine, carbon, etc.

Method used

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  • Compound containing carbon or oxygen isotope and preparation method thereof and application thereof and composition thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] This example is about the experiment of the antineoplastic drug doxorubicin on myocardial injury.

[0046] The specific process of this embodiment is as follows: take 3 mg doxorubicin and irradiate 30 Gy (Gray) at 50 MeV, after irradiation, the structure of doxorubicin does not change in any way according to the fluorescence analysis. After irradiation, the doxorubicin molecules on 12 The C atom transforms into 11 C positron nuclides, 16 The O atom transforms into 15 O positron nuclides, will have 11 C positron nuclides and 15 After doxorubicin of O positron nuclide was injected into the tail vein of SD rats (outbred group of rats), heart accumulation of doxorubicin could be observed.

Embodiment 2

[0048] This example is about the in vivo distribution research of anti-inflammatory drugs

[0049] Cefoperazone sodium is a pro-inflammatory focus antibiotic, after 30Gy irradiation at 50MeV, the 12 The C atom transforms into 11 C positron nuclides, 16 The O atom transforms into 15 O positron nuclides, will 11 C and 15 O-labeled cefoperazone was injected into the body, and PET / CT (CT is the abbreviation of computed tomography) showed obvious accumulation of cefoperazone in the right leg of SD rats with inflammation, while there was almost no cefoperazone in the left leg of normal control distributed.

Embodiment 3

[0051] This example is about glucose metabolism research in rats

[0052] Glucose is one of the main compounds that provide energy for the body. After 30Gy irradiation at 50MeV, the glucose molecules 12 The C atom transforms into 11 C positron nuclides, 16 The O atom transforms into 15 O positron nuclides, will 11 C and 15 When O-labeled glucose is injected into the body, PET / CT shows that the myocardium, skeletal muscle, and liver metabolize glucose, and the metabolites are excreted to the bladder through the kidneys.

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Abstract

The invention relates to a compound containing a carbon or oxygen isotope and a preparation method thereof and applications of the compound containing the carbon or oxygen isotope in positron or other nuclide imaging, and obtaining distribution or metabolic images of the compound containing the carbon or oxygen isotope in organisms, and composition containing the compound containing the carbon or oxygen isotope. The preparation method for the compound containing the carbon or oxygen isotope is as follows: irradiating a compound containing carbon or oxygen by rays, wherein the energies of the rays are at 20-430 MeV, and carbon or oxygen atoms of the compound containing carbon or oxygen produce carbon or oxygen positron nuclides by photonuclear reaction without breaking the molecular structure of the compound so as to produce compounds containing carbon or oxygen isotopes. The compound obtained by the method disclosed by the invention is used in the organism and can clearly mark the distribution and metabolic states of the compound containing the carbon or oxygen isotope.

Description

technical field [0001] The present invention relates to a compound containing carbon or oxygen isotope and its preparation method, the application of the compound containing carbon or oxygen isotope in positron or other nuclide imaging, the compound containing carbon or oxygen isotope in obtaining The application of the isotope compound in the distribution or metabolism image of the organism, and the composition containing the carbon or oxygen isotope compound. Background technique [0002] Nuclear medicine examinations, represented by positron emission tomography (abbreviated as PET), scintillation tomography (abbreviated as DS), and single photon emission computed tomography (abbreviated as SPECT), play an important role in diagnosing a variety of diseases, including heart disease and effective in cancer). These techniques involve administering to a patient an agent labeled with a specific radioisotope (abbreviated as a radiopharmaceutical), followed by detection of gamma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07B59/00C07H15/252C07H1/00C07D501/36C07D501/04C07H3/02C07D487/22C07F9/38A61K51/00A61K101/00
CPCA61K51/04A61K51/0453C07H15/24A61K51/0421A61K51/0451
Inventor 曾骏孙启银
Owner BEIJING TOP GRADE HEALTHCARE MEDICAL EQUIP CO LTD