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Cosmetic composition comprising chestnut shell extract

A technology of composition and cosmetics, applied in the direction of drug combination, medical preparations containing active ingredients, cosmetics, etc., can solve the problems of blocking cytochrome, no sedative effect, discouragement, etc.

Inactive Publication Date: 2012-05-16
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In addition, it is known that the first-generation antihistamines are mainly used for systemic administration, have anti-parasympathetic effects and exhibit sedative effects, and chlorpheniramine, which is a first-generation antihistamine, cannot suppress atopy when administered locally. Pruritus in patients with dermatitis (Munday et al., Dermatology, 205, pp40-45, 2002), the use of topical antihistamines in atopic dermatitis is discouraged due to the risk of allergic skin reactions
Ebastine and terfenadine, which are second-generation antihistamines without sedative effects, may cause arrhythmia when taken together with drugs that inhibit the activity of cytochrome (cytochrome) P450 (ketoconazole, erythromycin) Qi (Hey et al., Arzneimittelforschung, 46, pp159-163, 1996), causing side effects associated with it

Method used

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  • Cosmetic composition comprising chestnut shell extract
  • Cosmetic composition comprising chestnut shell extract
  • Cosmetic composition comprising chestnut shell extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] [Example 1] Preparation of Chestnut Peel Extract

[0049] 1-1) Preparation of chestnut peel 1,3-butanediol extract

[0050] Utilizing 30% 1,3-butanediol (1,3-butylene glycol), the fruit skin was leached at room temperature for 3 days. Next, filtration was performed sequentially with filters having a size of 250 mesh, 3 μm, 1 μm, and 0.5 μm. Then, after standing at 0 to 4° C. for 3 days, the 1,3-butanediol extract of chestnut skin was obtained by filtering through filters of 0.5 μm, 0.3 μm, and 0.2 μm in order.

[0051] 1-2) Preparation of Chestnut Bark Ethanol Extract

[0052] Using 70% ethanol, the chestnut skin was leached at room temperature for 3 days. Next, filtration was performed sequentially with filters having a size of 250 mesh, 3 μm, 1 μm, 0.5 μm, 0.3 μm, and 0.2 μm. Then, after concentrating the solution at 60° C., vacuum drying was performed at 30° C. for 18 hours to obtain a chestnut peel ethanol extract in a powder form.

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Abstract

The present invention relates to a cosmetic composition for alleviating or suppressing pruritus, comprising chestnut shell extract as an active ingredient. According to one embodiment of the present invention, the cosmetic composition containing the chestnut shell extract is suitable for use as an active ingredient in a cosmetic composition for alleviating or suppressing pruritus since it has exhibited proven, superior effects in alleviating or suppressing pruritus by suppressing the activity of proteinase-activated receptor-2 (PAR-2) which is a causative agent for pruritus.

Description

technical field [0001] The present invention relates to a cosmetic composition containing chestnut peel extract. Background technique [0002] Pruritus is defined as an unpleasant skin sensation that induces the desire to scratch, recognized as a physiological self-defense mechanism such as pain, touch, cold or heat when the skin is exposed to noxious stimuli from the outside. Known to play a role in protecting the skin. [0003] Pruritus is one of the common symptoms that often appear in various skin diseases or systemic diseases. In fact, acute pruritus caused by urticaria and side effects of various drugs can be easily cured, but biliary atresia, Treatment of severe chronic pruritus such as kidney disease or atopy is difficult. [0004] Pruritus is induced by various reasons such as inflammation, cancer, metabolic disease, infection, psychiatric disease, drug administration or stress. In several recent research results, the organic connection and targeting of the skin w...

Claims

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Application Information

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IPC IPC(8): A61K8/97A61Q19/00
CPCA61K8/97A61K36/49A61Q19/005A61K8/9789A61P17/00A61P17/04A61P17/06A61P17/08A61P17/16A61P29/00A61P37/06A61P37/08A61Q19/00A61Q19/007
Inventor 金赫金善暎沈范尹侦训高在濚申洪柱朴元锡朱泳協朴永镐
Owner AMOREPACIFIC CORP
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