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Treatment and prevention of dengue virus infections

A composition, selected technology, applied in the directions of antiviral agents, botanical equipment and methods, preparations for in vivo experiments, etc., can solve the problems of time delay of onset of immunity, side effects, etc.

Inactive Publication Date: 2012-05-23
SIGA TECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While a successful vaccine can be a critical part of effective biodefense, the often delayed timing of onset of immunity, possible side effects, cost, and logistics associated with mass civilian vaccination against low-threat risks imply comprehensive biodefense Include a separate quick response element

Method used

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  • Treatment and prevention of dengue virus infections
  • Treatment and prevention of dengue virus infections
  • Treatment and prevention of dengue virus infections

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0107] Example 1 - Formulation 1

[0108] Hard gelatin capsules containing the following ingredients were prepared:

[0109]

[0110] The above ingredients were mixed and filled in hard gelatin capsules in an amount of 340 mg.

Embodiment 2

[0111] Example 2 - Formulation 2

[0112] Tablets were prepared using the following ingredients:

[0113]

[0114]The components are blended and compressed into tablets, each weighing 240 mg.

Embodiment 3

[0115] Example 3 - Formulation 3

[0116] A dry powder inhaler was prepared containing the following components:

[0117]

[0118] Mix the active blend with lactose and add the mixture to the dry powder inhaler.

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PUM

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Abstract

Methods and pharmaceutical compositions for treating viral infections, by administering certain 2-aryl-benzothiazole or 2-heteroaryl-benzothiazole derivative compounds in therapeutically effective amounts are disclosed. Methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to and benefits of US Provisional Application No. 61 / 221,773, filed June 30, 2009, the contents of which are hereby incorporated by reference in their entirety. field of invention [0003] The present invention relates to 2-aryl-benzothiazole or 2-heteroaryl-benzothiazole derivatives and analogs and compositions comprising them for the treatment or prevention of viral diseases associated with the family Flaviviridae (e.g. dengue fever, Fever, West Nile Fever, St. Louis Encephalitis, Hepatitis C, Murray Valley Encephalitis, and Japanese Encephalitis). Background of the invention [0004] Dengue fever (DF) is an acute febrile illness caused by one of four closely related viral serotypes (DEN-1, DEN-2, DEN-3 and DEN-4). Dengue fever is classified according to its clinical features: classic dengue fever, or the more severe forms dengue hemorrhagic fever syndrome (DHF) and dengue shock synd...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/78
CPCA61K9/0019A61K31/675A61K31/7056A61K31/428A61K9/2054A61K9/4866A61K47/38A61K38/21A61K9/02A61K47/06A61K9/0075A61K9/0014A61K45/06A61K31/454A61K31/496A61K31/5377A61K31/625A61P31/12A61P31/14Y02A50/30A61K2300/00A61K2121/00
Inventor 切尔西·M·伯德戴冬成罗伯特·乔丹丹尼斯·E·赫鲁比
Owner SIGA TECH INC