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Shenkang sodium chloride injection for treating chronic renal failure and preparation method of Shenkang sodium chloride injection

A technology of Shenkang sodium chloride and chronic renal failure, which is applied in the fields of medical formula and drug delivery, which can solve the problems of affecting drug efficacy, no proportion relationship, and high usage of astragalus, and achieve rapid action, short course of treatment, and bioavailability high degree of effect

Active Publication Date: 2013-10-16
XIAN SHIJISHENGKANG PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The original patent 96117626.1 discloses a kind of Shenkang injection and its preparation method. Its prescription protects the scope of use of traditional Chinese medicine, and there is no specific ratio relationship. The dosage is high, because astragalus and rhubarb have a precipitation reaction, astragalus and salvia miltiorrhiza can also react, if the dosage of astragalus is small in the compatibility of the preparation, it will affect the efficacy of the medicine

Method used

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  • Shenkang sodium chloride injection for treating chronic renal failure and preparation method of Shenkang sodium chloride injection
  • Shenkang sodium chloride injection for treating chronic renal failure and preparation method of Shenkang sodium chloride injection
  • Shenkang sodium chloride injection for treating chronic renal failure and preparation method of Shenkang sodium chloride injection

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Effect test

Embodiment 1

[0109] The Shenkang sodium chloride injection of the present invention is made of the following raw materials: 1500g of rhubarb, 1500g of salvia miltiorrhiza, 4500g of astragalus, 1500g of safflower and 810g of sodium chloride.

[0110] After extracting the raw materials rhubarb and salvia miltiorrhiza according to the proportion of the above formula, first alcohol precipitation, detanning, second alcohol precipitation, water precipitation, third alcohol precipitation, and second water precipitation, depyrogenation and sterilization; Extract astragalus and safflower according to the proportion of the above formula, alcohol precipitation, water precipitation, alcohol precipitation and water precipitation again, activated carbon depyrogenation, and sterilization; finally combine the above two groups of dilutions, ultrafiltration, It is made by adding sodium chloride, fine filtration→subpackaging→sterilization→quality inspection→packaging.

Embodiment 2

[0112]Shenkang sodium chloride injection of the present invention is made according to the following preparation method: get rhubarb and salvia miltiorrhiza, the amount of water added for the first time is 7-12 times the amount of the original medicinal material, after soaking for 30 minutes, boil for 30 minutes, filter, and the second time The amount of water added for the first time is 7-12 times the amount of the original medicinal material, boiled for 30 minutes, filtered, the amount of water added for the third time is 7-12 times the amount of the original medicinal material, boiled for 30 minutes, filtered, combined three water extracts, concentrated to relative density 1.18-1.25 at 60°C, add 95% ethanol until the alcohol content of the liquid is 70%, let stand for 38-60h, take the supernatant and filter until clear, recover ethanol until the relative density is 1.18-1.25 at 60°C, add 5% gelatin solution, remove tanning, add 95% ethanol until the alcohol content is 75%, l...

Embodiment 3

[0114] The preparation method of Shenkang sodium chloride injection of the present invention is: after selecting 1500 g of rhubarb, 1500 g of salvia miltiorrhiza, 4500 g of astragalus and 1500 g of safflower, cleaning, soaking, cutting and drying; weighing 1500 g of rhubarb and 1500 g of salvia miltiorrhiza For medicinal materials, the amount of water added for the first time is 10 times the amount of the original medicinal materials, soaked for 30 minutes, boiled for 30 minutes, filtered, the amount of water added for the second time is 8 times the amount of the original medicinal materials, boiled for 30 minutes, filtered, and the amount of water added for the third time is 7 times the amount of the original medicinal material, boil for 30 minutes, filter, combine three water extracts, concentrate to a relative density of 1.20-1.22 at 60°C, add 95% ethanol, until the alcohol content of the liquid is 70%, let it stand for 48-60h , take the supernatant and filter until clear, r...

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Abstract

The invention relates to a Shenkang sodium chloride injection for treating chronic renal failure, which is prepared from the following raw materials in the mass ratio: 1500g of rheum officinale, 1500g of roots of red-rooted salvia, 4500g of Astragalus mongholicus, 1500g of red flower and 810g of sodium chloride. The preparation method comprises the following steps of: after the bulk pharmaceutical chemicals of the rheum officinale and the roots of the red-rooted salvia are extracted in the ratio in the formula, carrying out primary ethanol precipitation, removing tan, carrying out secondary ethanol precipitation and water precipitation, carrying out third ethanol precipitation, and carrying out secondary water precipitation to remove pyrogen and sterilize; then, extracting the red flower and the Astragalus mongholicus in the ratio in the formula, carrying out primary ethanol precipitation and water precipitation, and carrying out secondary ethanol precipitation and water precipitation to remove pyrogen and sterilize by activated carbon; and finally, combining the two groups of liquid medicine, carrying out ultrafiltration, adding sodium chloride, carrying out fine filtering and sterilizing to obtain the Shenkang sodium chloride injection. The Shenkang sodium chloride injection for treating chronic renal failure has the advantages that the Shenkang sodium chloride injection can be directly used to prevent medicine from being diluted again so as to lower secondary pollution brought by the process; the Shenkang sodium chloride injection is convenient for doctors and nurses to use, the compliance of a patient using the medicine is improved; and the Shenkang sodium chloride injection can be used for patients suffering from diabetes mellitus.

Description

technical field [0001] The invention belongs to traditional Chinese medicine preparation injection, in particular to a Shenkang sodium chloride injection for treating chronic renal failure and a preparation method thereof. Background technique [0002] The original patent 96117626.1 discloses a kind of Shenkang injection and its preparation method. Its prescription protects the scope of use of traditional Chinese medicine, and there is no specific ratio relationship. The dosage is high, because astragalus and rhubarb have a precipitation reaction, astragalus and salvia miltiorrhiza can also react, if the amount of astragalus is less in the compatibility of the preparation, it will affect the efficacy of the medicine. Precise and minimal side effects are critical for the active ingredient content of intravenous fluids. In addition, the present invention can be used directly, avoiding re-dilution of medicines, reducing possible secondary pollution during the process, facilita...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08
Inventor 曹凤君吕延英詹芳赵兴王光建王俊平
Owner XIAN SHIJISHENGKANG PHARMA IND
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