Pharmaceutical composition and purpose thereof

A composition and drug technology, applied in the field of biomedicine, can solve problems such as large blood pressure fluctuations and insignificant antihypertensive effects, improve the quality of life, help protect the structure and function of hypertensive target organs, and increase benefits/costs Effect

Active Publication Date: 2012-06-06
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] In order to solve the defects of the existing hypertension drugs with insignificant antihypertensive effect and large fluctuations in blood pressure during the antihypertensive process, the present invention provides a new pharmaceutical composition for treating hypertension and its complications. Tan and rosuvastatin are the active ingredients of the drug, which have comprehensive effects in the treatment of hypertension and its complications, can reduce cardiovascular and cerebrovascular risks, and have a significant and stable antihypertensive effect

Method used

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  • Pharmaceutical composition and purpose thereof
  • Pharmaceutical composition and purpose thereof
  • Pharmaceutical composition and purpose thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of Example 1 Rosuvastatin Fimasartan Compound Tablet

[0029] Rosuvastatin 8g

[0030] Fimasartan 2g

[0031] Compressible starch 120g

[0032] Cyclodextrin 10g

[0033] Sodium carboxymethyl starch 10g

[0034] Magnesium stearate 0.6g

[0035] 5% PVP in absolute ethanol solution

[0036] Preparation process: first put rosuvastatin and cyclodextrin into a mortar, grind and mix evenly, then add carboxymethyl starch sodium, compressible starch and mix evenly, finally add fimasartan and mix evenly, and use 5% PVP The anhydrous ethanol solution is used as a binder to granulate, dried at 40°C, granulated, added with magnesium stearate, mixed evenly, and compressed into tablets.

Embodiment 2

[0037] Example 2 Preparation of Rosuvastatin Fimasartan Compound Tablet

[0038] Rosuvastatin 8g

[0039] Fimasartan 80g

[0040] Compressible starch 130g

[0041] Cyclodextrin 10g

[0042] Sodium carboxymethyl starch 10g

[0043] Magnesium stearate 0.6g

[0044] 5% PVP in absolute ethanol solution

[0045] Preparation process: first put rosuvastatin and cyclodextrin into a mortar, grind and mix evenly, then add carboxymethyl starch sodium, compressible starch and mix evenly, finally add fimasartan and mix evenly, and use 5% PVP The anhydrous ethanol solution is used as a binder to granulate, dried at 40°C, granulated, added with magnesium stearate, mixed evenly, and compressed into tablets.

Embodiment 3

[0046] Preparation of Example 3 Rosuvastatin Fimasartan Compound Tablet

[0047] Rosuvastatin 0.1g

[0048] Fimasartan 25g

[0049] Microcrystalline Cellulose 150g

[0050] β-cyclodextrin 10g

[0051] Sodium carboxymethyl starch 15g

[0052] Micronized silica gel 0.8g

[0053] Preparation process: first put rosuvastatin and β-cyclodextrin into a mortar, grind and mix evenly, then add sodium carboxymethyl starch, microcrystalline cellulose, and micropowder silica gel to mix evenly, and finally add Fimasartan and mix evenly , and the powder is directly compressed into tablets.

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Abstract

The invention belongs to the filed of medicine and discloses a pharmaceutical composition using fimasartan and rosuvastatin or medicinal salt thereof as active components, wherein a mass ratio of rosuvastatin or medicinal salt thereof to fimasartan is 1:0.25-250 and preferably 1:10-100. The pharmaceutical composition containing rosuvastatin medicinal salt thereof and fimasartan has obvious synergism on treating hypertension and complications thereof, low treatment cost, little side-effect and good clinic application prospect.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a pharmaceutical composition and its application, in particular to a pharmaceutical composition with Fimasartan and Rosuvastatin as active ingredients and its preparation for treating hypertension and its complications. Uses in medicine. Background technique [0002] Hypertension is the most common cardiovascular disease in the world, and it is also one of the largest epidemics. It often causes complications in the heart, brain, kidney and other organs, and seriously endangers human health. Early prevention and timely treatment are of great significance, and the research and development of drugs for the treatment of cardiovascular diseases has become one of the hot spots in the field of medical research. [0003] Hypertension is a syndrome with very complicated etiology and pathogenesis. Once diagnosed, it requires life-long medication. At present, domestic and foreign medical circles ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/513A61K31/505A61K9/20A61K9/22A61K9/48A61K9/16A61P9/12
Inventor 赵志全王洪臣
Owner LUNAN PHARMA GROUP CORPORATION
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