Preparation method for fullerene amino acid derivative

A technology of fullerene amino acids and derivatives, applied in the fields of drug combination, antidote, organic chemistry, etc., can solve the problems of low biological activity and limited amino acids, and achieve the effect of high biological activity and improved reactivity

Inactive Publication Date: 2012-06-20
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention aims to solve the problems that the fullerene amino acid derivatives prepared in the prior art hav...

Method used

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  • Preparation method for fullerene amino acid derivative
  • Preparation method for fullerene amino acid derivative
  • Preparation method for fullerene amino acid derivative

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specific Embodiment approach 1

[0009] Embodiment 1: This embodiment is a method for preparing a fullerene amino acid derivative, which is specifically completed according to the following steps:

[0010] 1. Dissolve amino acid and phase transfer catalyst in deionized water at room temperature, and mix well, then add alkaline bromine water, and mix well at room temperature to obtain the mixture; Add the toluene solution of fullerene to the mixture prepared in step 1 at room temperature at 1000 rpm, and then react at 30°C to 80°C under nitrogen protection for 1 to 3 days to obtain the reaction product; 3. First, use toluene to extract Remove the remaining fullerenes in the reaction product, then use gel chromatography to elute, and collect the eluate within 3min to 30min, and finally concentrate and dry the obtained eluent at a temperature of 60°C to 100°C for 12h ~24h, the fullerene amino acid derivatives are obtained.

[0011] The molar ratio of the amino acid to the phase transfer catalyst described in st...

specific Embodiment approach 2

[0040] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the alkaline bromine water described in step one is made of H 2 O, NaOH and Br 2 mixed, and H 2 The molar ratio of O to NaOH is 1: (0.01~1), H 2 O and Br 2 The molar ratio is 1: (0.01~1). Others are the same as in the first embodiment.

specific Embodiment approach 3

[0041] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the phase transfer catalyst described in step 1 is tetrabutylammonium bromide or tetrabutylammonium hydroxide. Others are the same as in the first or second embodiment.

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Abstract

The invention discloses a preparation method for a fullerene amino acid derivative, which relates to a preparation method for a fullerene derivative and is mainly used for solving the problems of low bioactivity and limitation on selectable amino acids existing in a fullerene amino acid derivative prepared with the prior art. The method comprises the following steps of: I, uniformly mixing an amino acid with a phase transfer catalyst, and adding alkaline bromine water to obtain a mixture; II, adding a toluene solution of fullerene into the mixture to obtain a reaction product; and III, extracting the reaction product, eluting with gel chromatography, and concentrating and drying a collected eluent to obtain the fullerene amino acid derivative. The preparation method has the advantages that: I, the bioactivity of the fullerene amino acid derivative is high; and II, the fullerene amino acid derivative can be prepared by reacting an amino acid only containing alpha amino with fullerene. The preparation method is mainly used for preparing the fullerene amino acid derivative.

Description

technical field [0001] The invention relates to a preparation method of fullerene derivatives. Background technique [0002] The discovery of the third allotropic fullerene family as the carbon element is one of the important breakthroughs in the history of natural science. The unique three-dimensional structure of fullerene endows it with special physical and chemical properties, and makes it imply many new properties and functions to be discovered, which provide a broad space for the development of fullerene science. Research on fullerenes has involved many disciplines and research fields such as life and medical science, physics, chemistry, and material science. The biological properties of fullerenes provide broad prospects for its application in biomedicine. In recent years, studies on the physical and chemical properties of fullerene have found that it has a strong ability to react with free radicals. It has been reported that a single fullerene molecule can add 34 m...

Claims

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Application Information

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IPC IPC(8): C07D203/02C07D203/26A61P39/06A61P39/02
Inventor 胡桢黄玉东李翠云赵生俊李群
Owner HARBIN INST OF TECH
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