Chinese medicinal extract for treating diabetic peripheral neuropathy and preparation method thereof

A technology for peripheral neuropathy and extracts, which can be used in nervous system diseases, drug combinations, pharmaceutical formulations, etc., and can solve the problem that the pathogenesis is not fully elucidated.

Active Publication Date: 2012-06-27
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its pathogenesis has not been fully elucidated so far, and there is no effective treatment in modern medicine.

Method used

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  • Chinese medicinal extract for treating diabetic peripheral neuropathy and preparation method thereof
  • Chinese medicinal extract for treating diabetic peripheral neuropathy and preparation method thereof
  • Chinese medicinal extract for treating diabetic peripheral neuropathy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1, preparation is used for the treatment of the traditional Chinese medicine compound granule of diabetic peripheral neuropathy

[0032] 1. Prescription

[0033] Astragalus 600g Salvia 600g Dog Ridge 400g Achyranthes Knuckle 400g

[0034] Papaya 400g Yanhusuo 400g Radix Paeoniae Alba 400g

[0035] 2. Preparation method

[0036] The above 7 flavors, Radix Astragali, Salvia Miltiorrhiza and Corydalis Corydalis are extracted 3 times with 60% ethanol aqueous solution, heated and refluxed, and the amount of alcohol added each time is 6 times the mass of the medicinal materials, extracted for 1.5 hours each time, combined with the extracts, filtered to obtain the filtrate (1). Combine the dregs of Radix Astragali, Salvia Miltiorrhiza and Rhizoma Corydalis with Radix Paeoniae Rubra, add water and decoct 3 times at 100°C, add water 10 times the mass of the medicinal materials each time, decoct for 1.5 hours each time, combine the decoction, filter After filtering...

Embodiment 2

[0038]Embodiment 2, the clinical effect test of the traditional Chinese medicine compound granule for the treatment of diabetic peripheral neuropathy

[0039] 1 research object

[0040] 1.1 Western medicine diagnostic criteria: According to WHOPNTF's research on the diagnostic criteria of diabetic peripheral neuropathy, the following diagnostic criteria are formulated. ①Meet the WHO diagnostic criteria for diabetes (1999); ②Persistent pain and / or paresthesia in limbs (at least in both lower extremities); ③Weakened ankle reflexes on both sides or one side; ④Weakened vibration sense; Right-handed counting) Reduced nerve conduction velocity; ⑥ Excluding peripheral neuropathy caused by other factors (such as genetics, alcoholism, uremia, hypothyroidism, drugs, etc.).

[0041] 1.2 TCM syndrome differentiation standard: According to the syndrome differentiation standard of "Guiding Principles of Clinical Research of New Chinese Medicines", the syndrome belongs to deficiency of both...

Embodiment 3

[0111] Embodiment 3, preparation is used for the treatment of the traditional Chinese medicine compound granule of diabetic peripheral neuropathy

[0112] 1. Prescription

[0113] Astragalus 1200g Salvia miltiorrhiza 1200g Dog ridge 600g Achyranthes bidentata 600g

[0114] Papaya 600g Yanhusuo 600g Radix Paeoniae Alba 600g

[0115] 2. Preparation method

[0116] The above 7 flavors, Radix Astragali, Salvia Miltiorrhiza and Corydalis Corydalis are extracted 3 times with 50% ethanol aqueous solution under heating and reflux, and the amount of alcohol added each time is 8 times of the mass of the medicinal materials, and each time the extraction is 1.5 hours, the combined extracts are filtered to obtain the filtrate (1). Combine the dregs of Radix Astragali, Salvia Miltiorrhiza, Corydalis Corydalis with Radix Paeoniae Rubra, add water to decoct 3 times, the temperature of decoction is 100°C, the amount of water added each time is 8 times the mass of the medicinal material, dec...

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Abstract

The invention discloses a Chinese medicinal extract for treating diabetic peripheral neuropathy and a preparation method thereof. The Chinese medicinal extract is extracted from the following seven traditional Chinese medicines serving as raw materials in parts by mass: 600-1,200 parts of astragalus root, 600-1,200 parts of salvia miltiorrhizae, 400-600 parts of rhizoma cibotii, 400-600 parts of root of bidentate achyranthes, 400-600 parts of pawpaw, 400-600 parts of corydalis tuber and 400-600 parts of red paeony root. Clinical test results show that clinical symptoms of a patient of diabetic peripheral neuropathy can be obviously improved and nerve conduction velocity of the DPN patient can be effectively increased by the Chinese medicinal extract, and the overall effectiveness ratio reaches 90.3 percent; meanwhile, the improvement in the aspects of numbness, seismesthesia, spasm, touch sensation, pain, pinprick sensation and ankle reflection is also superior to that of a control group. The overall curative effect evaluation is obviously superior to that of a vitamin preparation, namely methycobal (P is less than 0.05), which is generally used in clinical practice at present. Blood routine and liver and kidney functions before and after treatment do not obviously differ; and during treatment, two groups of patients have no adverse effect. The compound granules are shown to be safe and effective for treating the diabetic peripheral neuropathy.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract for treating diabetic peripheral neuropathy and a preparation method thereof. Background technique [0002] Diabetic Peripheral Neuropathy (Diabetic Peripheral Neuropathy, DPN) is one of the most common chronic complications of diabetes, and its adult diabetes incidence rate reaches at least 60% [Edited by Xu Manyin, Diabetology, Shanghai Science and Technology Press, 2010 edition, page 435] . Diabetic peripheral neuropathy is the main cause of diabetic foot and amputation. It can increase the risk of amputation by 1.7 times. If foot deformity has occurred, the risk will increase by 12 times. Patients with a history of foot ulcers have a higher risk of amputation. increased by 36 times. At present, 50%-75% of amputations caused by non-traumatic reasons are caused by diabetic neuropathy. Once neuropathy occurs in diabetic patients, the quality of life will be seriously damaged, and the mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/732A61P3/10A61P25/02
Inventor 高彦彬
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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