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Pharmaceutical composition of lappaconitine hydrobromide

A technology of homogenin hydrobromide and composition, which is applied in the direction of drug combination, drug delivery, antipyretic, etc., which can solve the problems of poor taste, high incidence, inconvenient use, etc., and achieve good stability

Active Publication Date: 2013-08-28
BEIJING HUMANWELL JUNWEI PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although pharyngitis is not a serious illness or a serious illness, it often affects health and people's normal work and life because of its high incidence rate, large number of patients, and easily being underestimated.
At present, there are many medicines for the treatment of acute and chronic pharyngitis, but their curative effects are not ideal enough, and some have factors such as inconvenient use or bad taste.

Method used

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  • Pharmaceutical composition of lappaconitine hydrobromide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation of embodiment 1, homogenine hydrobromide spray

[0032] Weigh 0.03g of methyl p-hydroxybenzoate, put it in a 100mL volumetric flask, add an appropriate amount of water for injection, heat it in a warm water bath to dissolve, cool to room temperature, then add 1.0g of uricine hydrobromide, 2g of citric acid, stevia Glycoside 0.5mg, sidimenthol 2.0g, shake to dissolve, add water for injection near the mark, shake well, adjust to pH 4.0 with 0.1M sodium hydroxide (or 0.1M hydrochloric acid if necessary), and then inject Water to the mark, shake well, and filter with 0.45 μm microporous membrane to obtain homogenate hydrobromide spray solution, which is then filled in a single-dose or multi-dose spray device, and packed for later use.

[0033] Described sidimenthol is prepared by the ratio of HP-β-cyclodextrin (referred to as β-CD in the following steps) and Menthol with a weight ratio of 125:20, and its detailed preparation steps are as follows:

[0034]...

Embodiment 2

[0037] The preparation of embodiment 2, homogenine hydrobromide spray

[0038] Weigh 0.05g of propyl p-hydroxybenzoate, put it in a 100mL volumetric flask, add 20g of propylene glycol, add an appropriate amount of water for injection, heat in a warm water bath to dissolve, cool to room temperature, and then add 1.0g of homogenin hydrobromide, citrate Citric acid 1g, stevioside 0.5mg, menthol (see Example 1 for preparation) 2.0g, shake to dissolve, add water for injection near the mark, shake well, and use 0.1M sodium hydroxide (or if necessary, use 0.1 M hydrochloric acid) to adjust to pH 4.5, add water for injection to the scale, shake well, and filter with 0.45 μm microporous membrane to obtain homogenin hydrobromide spray liquid, which can then be filled in single dose or multi-dose Dosage spray device, packed ready for use.

Embodiment 3

[0039] Embodiment 3, the preparation of homogenin hydrobromide aqueous solution

[0040]Take 0.2 g of uricine hydrobromide, 4 g of sodium citrate, and 1 g of tartaric acid, add water to about 90 ml, dissolve, and adjust the pH value to 3.5 with 0.1 M hydrochloric acid (or 0.1 M sodium hydroxide if necessary), Add water for injection to 100ml, shake well, and get ready.

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Abstract

The invention discloses a pharmaceutical composition of lappaconitine hydrobromide, which is an aqueous solution of lappaconitine hydrobromide and has a pH value of 3.5 to 6.0. The pharmaceutical composition of lappaconitine hydrobromide can be used for treating acute pharyngitis and chronic pharyngitis.

Description

technical field [0001] The invention relates to a pharmaceutical composition of uricine hydrobromide which can be used for treating acute and chronic pharyngitis. Background technique [0002] Pharyngitis is a common disease, the main causes of which are cold, fatigue, long-term stimulation by dust or harmful gas, sinusitis secretion stimulation, excessive drinking or other bad living habits, allergies or reduced body resistance. Though pharyngitis is not serious illness, serious illness, because of its high incidence rate, many patients, easily underestimated and other reasons, it often affects health and people's normal work and life. The medicine that is used for the treatment of acute and chronic pharyngitis is more at present, but its curative effect is all not ideal enough, also has factors such as inconvenient use or bad taste. [0003] Hokine hydrobromide is an antipyretic, analgesic, and anti-inflammatory drug, and its pharmacological effects show that Hokine hydro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K9/12A61K31/439A61P11/04A61P29/00
Inventor 高永良魏丽韩勤
Owner BEIJING HUMANWELL JUNWEI PHARM TECH CO LTD