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Wogonin liposome preparation modified with glycyrrhetinic acid and preparation method thereof

A technology of liposome preparation and glycyrrhetinic acid, which is applied in the preparation of wogonin liposome preparation, in the field of wogonin liposome preparation, achieves the effect of high safety, good biocompatibility and superior safety

Inactive Publication Date: 2012-07-04
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the amount of GA modification has a great influence on the anti-tumor effect of liposomes, and the selection of an appropriate ratio of modified materials to achieve a better targeted anti-tumor effect needs further study

Method used

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  • Wogonin liposome preparation modified with glycyrrhetinic acid and preparation method thereof
  • Wogonin liposome preparation modified with glycyrrhetinic acid and preparation method thereof
  • Wogonin liposome preparation modified with glycyrrhetinic acid and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0046] Weigh 4mgHHQS and 24mgArg in a 25ml small beaker, add an appropriate amount of distilled water for ultrasonic dissolution, heat and boil in an electric furnace, and wait until all dissolved. Transfer to a 10ml measuring cylinder and add water to a certain volume, which is the water phase. Weigh 200 mg of soybean lecithin and 20 mg of cholesterol into a 50 ml eggplant-shaped bottle, and add about 8 ml of dichloromethane to dissolve by ultrasonic to obtain an oil phase. The water phase was slowly added dropwise to the oil phase under ultrasonication in a water bath, and it was milky and uniform, and the ultrasonication was continued for 10 min. Remove dichloromethane by rotary evaporation, pay attention to control the vacuum degree, and try to avoid foaming. After the dichloromethane was basically removed, the inside of the bottle was first viscous, agglomerated, and then collapsed to form a liquid. Add hydration medium. Hydrate at 30°C for 2h. Probe ultrasound, 500w,...

Embodiment 2

[0048] Weigh 4mgHHQS and 24mgArg in a 25ml small beaker, add an appropriate amount of distilled water for ultrasonic dissolution, heat and boil in an electric furnace, and wait until all dissolved. Transfer to a 10ml measuring cylinder and add water to a certain volume, which is the water phase. Weigh 200 mg of soybean lecithin and 20 mg of cholesterol into a 50 ml eggplant-shaped bottle, and add about 8 ml of dichloromethane to dissolve by ultrasonic to obtain an oil phase. Weigh 10 mg of 18-GA-Suc to dissolve in the oil phase. The water phase was slowly added dropwise to the oil phase under ultrasonication in a water bath, and it was milky and uniform, and the ultrasonication was continued for 10 min. Remove dichloromethane by rotary evaporation, pay attention to control the vacuum degree, and try to avoid foaming. After the dichloromethane was basically removed, the inside of the bottle was first viscous, agglomerated, and then collapsed to form a liquid. Add hydration m...

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Abstract

The invention belongs to the technical field of medicine and relates to a wogonin liposome preparation modified with glycyrrhetinic acid and a preparation method of the wogonin liposome preparation. Through adoption of the wogonin liposome modified with a glycyrrhetinic acid derivative prepared by a reverse evaporation method, the action efficacy on liver tumor cells is obviously improved and the therapeutic effect on liver cancer is enhanced.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a wogonin liposome preparation modified by glycyrrhetinic acid, and also discloses a preparation method of the wogonin liposome preparation. Background technique [0002] Wogonin is one of the main active components of Scutellaria baicalensis, and 41 kinds of flavonoids have been found from Scutellaria baicalensis. , Wogonin and Melaleuca, etc. Among them, wogonin can affect drug metabolism enzymes (inhibit the activity of CYP2E1, 3A, 1A2 and UGT), inhibit liver tumor cells, and have protective effects on liver damage caused by CCL4, β-galactosamine and alcohol. [0003] The main active ingredient of licorice is glycyrrhizin (GL), which is widely used clinically to protect the liver, prevent cirrhosis and treat various acute and chronic hepatitis, bronchitis and AIDS. But it is worth noting that: GL is metabolized into glycyrrhetinic acid (GA) in vivo to play its role...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K31/352A61K47/28A61P35/00
Inventor 柯学王璐
Owner CHINA PHARM UNIV