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Integrated micro-valve droplet control chip and method for synthesizing and assembling polymer microspheres

A polymer, chip technology, used in microstructure devices, manufacturing microstructure devices, processes for producing decorative surface effects, etc.

Inactive Publication Date: 2012-07-04
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the colloidal particles are synthesized off-line and existed before being introduced into the microfluidic chip, the size and composition of a single colloidal particle cannot be changed online, which greatly limits the adjustment of the particle morphology by this method, especially the size inside the particle. and make up the sequence

Method used

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  • Integrated micro-valve droplet control chip and method for synthesizing and assembling polymer microspheres
  • Integrated micro-valve droplet control chip and method for synthesizing and assembling polymer microspheres
  • Integrated micro-valve droplet control chip and method for synthesizing and assembling polymer microspheres

Examples

Experimental program
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Effect test

Embodiment 1

[0041] The following examples will further illustrate the present invention, but do not limit the present invention thereby.

[0042] Example 1

[0043] The number control and bonding angle control of the experimental microsphere assembly was carried out by using figure 2 The structure of the chip shown is that the chip is composed of upper, middle and lower layers; among them, the upper layer is a liquid channel chip, which is composed of a liquid reservoir, a water phase channel and an oil phase channel; the middle layer is a thin film layer; the lower layer is a gas control chip. access chip; and the integrated microvalve is composed of liquid circuit, film and gas circuit control, and the material of the upper layer of the chip, the material of the middle film and the lower layer are all PDMS; then add 20ul mineral oil (4% span80 ), add 10ul NOA61 (including 10 5 M Rhodamine B), the reservoir 4 is connected to a syringe pump and pumped at a constant flow rate (0.6ul / mi...

Embodiment 2

[0045] Test the assembly of microparticles with a specific internal size sequence, taking the assembly of 2 large balls (A) and 2 small balls (B) as an example, there are 3 theoretical size sequences: A-B-A-B, A-A-B-B and A-B-B-A (see Figure 12 ). Using the method described in Example 1, according to Figure 12 Line 1, Line 2, and Line 3 shown in , form the corresponding droplet sequence (see Figure 13 middle row), and under the action of ultraviolet light, microparticles with a specific size sequence that exactly match the model are formed (see Figure 13 ). If assembled with 4 microspheres of different sizes (A, B, C, D), theoretically there are about 4 4 / 2 different size sequences, one of which is a sequence of sizes such as Figure 14 shown.

Embodiment 3

[0047] To test the assembly of microparticles with a specific internal composition sequence, add 10 ul NOA61 (containing 10 5 M Rhodamine B), add 10 ul NOA61 (containing 10 5 M rhodamine 123) (see Figure 15-1 ), using the method described in Example 1, to form microspheres (E and F) with 2 different components. Taking the assembly of 2 E balls and 2 F balls as an example, there are three theoretical composition sequences: E-E-F-F, E-F-E-F and E-F-F-E (see Figure 15-2 ). Using the method described in Example 1, according to Figure 15-2 The sequence of lines 1, 2, and 3 shown in Figure 1 produces a droplet sequence corresponding to the composition, and under the action of ultraviolet light, microparticles with a specific composition sequence that are completely consistent with theoretical predictions are formed (see Figure 15-3 ).

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Abstract

The invention provides a method for synthesizing and assembling polymer microspheres based on an integrated micro-valve droplet control chip. The method comprises the following steps: a series of micro-droplets of polymer monomers are generated by the opening and closing of a program controlled micro-valve; under the illumination of ultraviolet, the micro-droplets are solidified to form microspheres; and the online assembly, bonding and release of the microspheres are realized in a downstream channel. The method has the following advantages: the length of assembled particles is controlled by the opening times of a single-circulation nickel micro-valve; the bonding angle of the microspheres is controlled by controlling the relative dimension of uniform microspheres and the channel; and the internal dimension and the composition sequence of the assembled particle are controlled by controlling the dimension and the composition of single microspheres.

Description

technical field [0001] The invention relates to the synthesis technology of anisotropic polymer microparticles, and in particular provides an integrated microvalve droplet control chip and a method for synthesizing and assembling polymer microspheres. Background technique [0002] Anisotropic microparticles are widely used in self-assembly, drug carrier design, and analysis of biochemical codes. The anisotropy of particles can also be used to detect the rheological properties of complex fluids, which has potential application value in food materials, cosmetics, pharmaceuticals and other fields. The traditional seed polymerization method is based on the thermodynamic process of phase separation, and uses the controlled reaction kinetic process to synthesize core-shell or non-spherical particles. However, the resulting particles are poorly monodisperse and the process is time consuming. In order to obtain particles with good monodispersity and complex structure, droplet micr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B81C1/00
Inventor 秦建华张清泉林炳承
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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