Unlock instant, AI-driven research and patent intelligence for your innovation.

Application of alpha-hydroxy carboxylic acid replaced by phenoxy

A technology of hydroxycarboxylic acid and hydroxyphenoxypropionic acid, which can be used in cosmetic preparations, skin care preparations, pharmaceutical formulations, etc., and can solve problems such as dull skin and loss of luster.

Inactive Publication Date: 2012-07-11
COGNIS IP MANAGEMENT GMBH
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But even few physiological factors (e.g. hormones, inflammation) or environmental factors (UV radiation, pollution, oxidative stress) can make the skin dull and dull

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of alpha-hydroxy carboxylic acid replaced by phenoxy
  • Application of alpha-hydroxy carboxylic acid replaced by phenoxy
  • Application of alpha-hydroxy carboxylic acid replaced by phenoxy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Substance

[0026] Hydroxyphenoxypropionic acid, racemic compound [CAS No. 67648-61-7] (A) or R-enantiomer [CAS No. 94050-90-5] (B) can be obtained from Sigma-Aldrich.

Embodiment 2

[0027] Example 2: Antioxidant activity / anti-radical activity

[0028] Free radicals (FR) are reactive chemical forms that are characterized by one (or more) unpaired electrons. FR can be derived from unsaturated lipids, certain amino acids, and mainly derived from oxygen during spontaneous biological mechanisms (such as the respiratory chain in mitochondria) or natural biological processes (such as inflammation). In fact, FR reacts with oxygen to form reactive oxygen species (ROS) such as hydroxyl radical HO. In addition, oxidative stress such as UV or pollutants also generates free radicals and ROS, which cause damage to all cells and tissue components (lipids, proteins, sugars, and nucleic bases) of human skin.

[0029] The antioxidant capacity of compound B was evaluated by DPPH test and HO test.

[0030] -Anti-DPPH test

[0031] [DEBY C: Relation entre les acides gras essentiels et le taux des antioxydants tissulaires chez la souris: SOCIETE BELGE DE BIOLOGIE, security du 19 dé...

Embodiment 3

[0042] Example 3: UVA photoprotection, cellular antioxidant effect

[0043] UVA radiation penetrates the epidermis and induces oxidative stress in the dermis by generating reactive oxygen species or ROS [see DALLE CARBONARE M, PATHAK MA: Skin photosensitizing agents and the role of reactive oxygen species in photo-aging. Journal of Photochemistry & Photobiology, 14, 1-2, 105-124, 1992]. Oxidative stress leads to the oxidation of cell membrane lipids and reduced forms of glutathione [MORLIERE P, MOISAN A, SANTUS R, HUPPE G, MAZIERE JC, DUBERTRET L: UV-A induced lipid peroxydation in cultured human fibroblasts. Biochim. Biophys. Acta, 1084, 3:261-269, 1991].

[0044] By measuring the release levels of malondialdehyde (MDA), intracellular proteins and GSH (reduced form of glutathione), the cytoprotective effect of UVA-induced injury of human fibroblasts (MRC5 cell line) cultured in vitro was evaluated. MDA is a by-product of lipid oxidation and glutathione is a natural peptide that...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an application of alpha-hydroxy carboxylic acid make-up replaced by phenoxy, which is used for protecting skin against ultraviolet induction, inflammatory and oxidative damage and is particularly suitable for improving skin luster and / or skin lackluster and / or skin uniformity and / or skin reddening.

Description

Technical field [0001] The present invention relates to the cosmetic use of phenoxy-substituted α-hydroxycarboxylic acids, for protecting the skin from UV-induced, inflammatory and oxidative damage, and especially for improving skin gloss and / or skin tone Dull complexion and / or skin evenness and / or skin redness. Background technique [0002] Alpha-hydroxycarboxylic acids (AHAs) are well known active substances for the treatment of acne. They can affect clinically detectable keratinization when a new stratum corneum is formed. AHAs are incorporated into creams, ointments and lotions used daily or used as exfoliants in higher concentrations. However, it is extremely important to use the right dosage, concentration and duration to avoid side effects. Very common side effects are redness, skin irritation and peeling. Chemical peels can cause more serious side effects, including blistering, burns, and skin discoloration. According to a warning issued by the FDA in accordance with...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/365A61Q5/00A61Q17/04A61Q19/00
Inventor 穆索.菲利普丹诺克斯.路易斯萨巴多托.梅拉妮
Owner COGNIS IP MANAGEMENT GMBH
PatSnap Eureka logo

PatSnap Eureka turns technology decisions into work you can execute. Powered by our Innovation Knowledge Graph, it runs expert workflows across engineering, life sciences, materials and intellectual property. Get your review-ready output in minutes.

X (Twitter)LinkedInYouTubeSubstack

© 2026 PatSnap. All rights reserved. 

Terms of Service

 | 

Privacy policy

 | 

Modern Slavery Act Transparency Statement