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Vaginal drug administration device comprising clotrimazole, metronidazole and chlorhexidine and preparing method thereof

A technology for vaginal administration and clotrimazole is applied in the field of preparation of the drug administration device, and can solve the problems of gastrointestinal reaction, leukopenia, high toxicity and the like

Active Publication Date: 2015-07-22
SHANGHAI INST OF PLANNED PARENTHOOD RES +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This product is highly toxic, and oral administration may cause gastrointestinal reactions, abnormal liver function and leukopenia, etc.

Method used

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  • Vaginal drug administration device comprising clotrimazole, metronidazole and chlorhexidine and preparing method thereof
  • Vaginal drug administration device comprising clotrimazole, metronidazole and chlorhexidine and preparing method thereof
  • Vaginal drug administration device comprising clotrimazole, metronidazole and chlorhexidine and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Use an injection molding machine to inject medical polyethylene (molecular weight 5000-21000) into an "O"-shaped bracket with an outer diameter of 40mm and a thickness of 2mm, such as figure 1 shown.

[0040] Such as figure 2 As shown, prepare an pearl cotton drug-loaded tube (purchased from Shanghai Si Ding Buffer Material Co., Ltd.) with an outer diameter of 9 mm, a thickness of 3.5 mm, and a length of 140 mm, and put the drug-loaded tube on the obtained "O" type stent .

[0041] Weigh 1g of metronidazole, 50mg of chlorhexidine, 0.3g of ethyl cellulose, and 4g of ethanol, mix the four evenly, and impregnate them on the "O"-shaped support of the polyurethane sponge drug-loaded tube prepared above to obtain A containing drug layer.

[0042] Weigh 0.3 g of clotrimazole, 0.2 g of sodium carboxymethyl cellulose, and 3 g of ethanol, mix the three evenly, and impregnate them on the outside of the drug-containing layer of A to obtain the drug-containing layer of B.

[00...

Embodiment 2

[0045] Use an injection molding machine to inject medical polyethylene material (molecular weight 2000-21000) into an "O" type stent. Its outer diameter is 4.5mm and its thickness is 2mm.

[0046] Such as figure 2 As shown, prepare a polyurethane sponge drug-loading tube with an outer diameter of 8 mm, a thickness of 4 mm, and a length of 140 mm (purchased from Shanghai Siding Buffer Material Co., Ltd.), and put the drug-loading tube on the obtained "O"-shaped stent.

[0047] Weigh 1g of metronidazole, 50mg of chlorhexidine, 0.1g of cellulose acetate phthalate, and 4g of ethanol, mix the four evenly, and impregnate them on the "O"-shaped support of the polyurethane sponge drug-loaded tube prepared above, A drug-containing layer is obtained.

[0048] Weigh 0.5 g of clotrimazole, 0.3 g of hydroxypropyl methylcellulose, and 4 g of ethanol, mix the three evenly, and impregnate them on the outside of the drug-containing layer of A to obtain the drug-containing layer of B.

[00...

Embodiment 3

[0051] The polyurethane material is injected into an "O"-shaped bracket with an injection molding machine, with an outer diameter of 4.0mm and a thickness of 2mm.

[0052] Such as figure 2 As shown, prepare a polyurethane sponge drug-loaded tube (purchased from Shanghai Si Ding Buffer Material Co., Ltd.) with an outer diameter of 7 mm, a thickness of 2.8 mm, and a length of 12.3 mm, and put the drug-loaded tube on the obtained "O" type stent superior.

[0053] Weigh 1.2g of metronidazole, 45mg of chlorhexidine, 0.1g of acrylic resin, and 5g of ethyl acetate, mix the four evenly, and impregnate them on the "O"-shaped support of the polyurethane sponge drug-loaded tube prepared above to obtain A Drug-containing layer.

[0054] Weigh 0.4 g of clotrimazole, 0.2 g of hydroxypropyl methylcellulose, and 5 g of water, mix the three evenly, and impregnate them on the outside of the drug-containing layer of A to obtain the drug-containing layer of B.

[0055] Weigh 0.3 g of methyl v...

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Abstract

The invention provides a vaginal drug administration device. The vaginal drug administration device comprises a stent and drug carrying tube, wherein the drug carrying tube comprises a mixture (a) of clotrimazole and dispersed pore-foaming controlled-release material and a mixture (b) of metronidazole, chlorhexidine and an isolated controlled-release material, wherein a weight ratio of the clotrimazole and the dispersed pore-foaming controlled-release material is 1:(0.02-2), the weight ratio of the mixture of the metronidazole and chlorhexidine to the isolated controlled-release material is 1:(0.01-2), the dosage of the clotrimazole is 300mg-400mg, the dosage of the metronidazole is 600mg-1200mg, and the dosage of the chlorhexidine is 30mg-60mg. The invention also provides a preparing method of the vaginal drug administration device. According to the vaginal drug administration device provided by the invention, the requirement of sustained-release preparations can be met, the purpose of constantly releasing the drugs every day is achieved, and an ultimate and one-off treatment means is provided for vaginitis.

Description

technical field [0001] The present invention relates to a human vaginal drug delivery device comprising clotrimazole, metronidazole and chlorhexidine, and also relates to a preparation method of the drug delivery device. Background technique [0002] "Vaginitis" is when the natural defense function of the vagina is damaged, pathogens are easy to invade, leading to vaginal inflammation. Common vaginitis includes non-specific vaginitis, fungal, trichomonal vaginitis and Haemophilus vaginalis vaginitis. Due to the extensiveness and universality of vaginitis and the diversity of its clinical symptoms, vaginal swelling, burning pain, vaginal itching, and increased vaginal secretions are purulent or serous. Examination shows that the entire vaginal mucosa is red and swollen. Damaged erosive surfaces or superficial ulcers can be seen. Some patients have transformed from acute inflammation to chronic inflammation or intractable inflammation due to untimely treatment, which has bro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M31/00A61L31/10A61L31/14
Inventor 邵海浩李元春陈建兴
Owner SHANGHAI INST OF PLANNED PARENTHOOD RES
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