Compound grapefruit oil nanoemulsion oral liquid for losing weight and preparation method thereof
A technology of grapefruit oil and oral emulsion is applied in the directions of emulsion delivery, pharmaceutical formulations, and medical preparations containing active ingredients, which can solve the problems of dependence rebound, easy to produce side effects, and great physical irritation, and achieve Less side effects, improved bioavailability, enhanced cosmetic effect
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Embodiment 1
[0047]1) Add 10.6 g of grapefruit oil and 2.8 g of seabuckthorn seed oil to 1.5 g of almond oil, stir evenly, and use it as the oil phase;
[0048] 2) Add 29.8 g EL-40 into the oil phase and stir well;
[0049] 3) Add 3.4 g of synephrine into 51.9 g of distilled water and stir until completely dissolved, as the water phase;
[0050] 4) Stir the solution prepared in step 2) rapidly at 20°C, and slowly add the water phase dropwise while stirring until a clear, transparent, yellow or colorless and transparent O / W nanoemulsion liquid with low viscosity and fluidity is formed, namely Obtain compound grapefruit oil nanoemulsion oral liquid.
Embodiment 2
[0052] 1) Add the stated amount of 4.7 g grapefruit oil and 1.8 g sea buckthorn seed oil to 0.8 g olive oil, stir evenly, and use it as the oil phase;
[0053] 2) Add 34.6 g RH-40 into the oil phase and stir well;
[0054] 3) Add 2.4 g of synephrine into 55.7 g of distilled water and stir until completely dissolved, as the water phase;
[0055] 4) Stir the solution prepared in step 2) rapidly at 25°C, and slowly add the water phase dropwise while stirring until a clear, transparent, yellow or colorless and transparent O / W nanoemulsion liquid with low viscosity and fluidity is formed, namely Obtain compound grapefruit oil nanoemulsion oral liquid.
Embodiment 3
[0057] It consists of 33.3 g of Tween-80, 0.4 g of seabuckthorn seed oil, 0.5 g of soybean oil, 1.1 g of synephrine, 3.5 g of grapefruit oil, and 61.2 g of distilled water.
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