Sesquiterpene compound black perianne j and its preparation method and use

Abstract

The invention relates to the medicine technical field, more specifically relates to a dimeric sesquiterpene compound Hippolide J separated from marine animal sponge, its preparation method and its purpose. sponge is extracted by ethanol according to a routine percolation method, concentrated, separated and purified to obtain Hippolide J, its molecular formula is C25H36O3; the preparation method has the advantages of simple technology, high yield and stable property, the prepared preparation has the advantages of stable quality, simple quality control and low production cost, and is convenient for industrial production; the compound can display inhibition activity on human lung carcinoma cell A549 and human cervical carcinoma cell Hela, and can be used for preparing antitumor drugs, the curative effect is substantial, the safety and low toxin can be provided, the usage is convenient, one compound enables multiple purposes, abundant source and low cost of raw materials are provided, the compound Hippolide J provides a novel medicine source and safe raw material for preventing, diagnosing, detecting, protecting, treating and researching anti-tumor, anti-diabetes, anti-obesity and directly relative diseases.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular to a compound derived from marine animals and its extraction, separation, use and other technical fields, more specifically to a compound isolated from marine animal sponges and its preparation The method and use, and more specifically relate to a sesquiterpene compound black perianne (HippolideJ) and its preparation method and use. Background technique [0002] (1) Overview of sponge research [0003] 1 Overview [0004] Sponge (English name: Spongiatia or Sponge, Latin literary name: Phylum Porifera) is the general term for porous animals, belonging to the animal kingdom paleontology paleinvertebrate zoology porous animal phylum (Porifera). The phylum Polyporea is a collective term for approximately 5,000 species of primitive multicellular aquatic animals. Except for about 20 species of the genus Spongilla, which are produced in freshwater, they are all distributed in ...

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Problems solved by technology

[0018] (2) No definite tissues and organs

In the 1970s and 1980s, some scholars believed that chemotherapy could lower the stage of lung cancer and increase the surgical resection rate, but there was considerable controversy.

[0256] ③ Radiotherapy: Radiotherapy is one of the main treatments for lung cancer, but radiotherapy is rarely used alone as the only treatment

[0290] ④ Infertility: Uterine fibroids can affect the structure of the uterine cavity and the operation of the endometrium, making implantation difficult

[0320] After searching the literature, so far, no product reports on the sesquiterpene compound HippolideJ have been found

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