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A kind of BCG polysaccharide nucleic acid inhalation aerosol, preparation method and application

A technology of BCG polysaccharide nucleic acid and BCG polysaccharide, which can be used in aerosol delivery, pharmaceutical formulations, respiratory diseases, etc., and can solve problems such as induration, infection, and patient pain

Inactive Publication Date: 2014-10-29
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the injection also has its limitations. The BCG polysaccharide nucleic acid needs long-term medication, and the patient needs to go to the hospital for injection, which is inconvenient for medication; the injection site is prone to ulcers, induration, infection, etc., causing pain to the patient.

Method used

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  • A kind of BCG polysaccharide nucleic acid inhalation aerosol, preparation method and application
  • A kind of BCG polysaccharide nucleic acid inhalation aerosol, preparation method and application
  • A kind of BCG polysaccharide nucleic acid inhalation aerosol, preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0052] Embodiment 1: a kind of BCG polysaccharide nucleic acid inhalation aerosol, prescription is:

[0053]

[0054] According to prescription quantity, surfactant oleic acid 1.0g is dissolved in the pretreatment solvent 15ml n-pentane, then add micronized BCG polysaccharide nucleic acid 0.048g, stir for 48 hours, remove the pretreatment solvent n-pentane under reduced pressure, To obtain a residue, add the residue, 100ml of propellant 1,1,1,2-tetrafluoroethane, and 0.04g of preservative ethylparaben into a pressure-resistant container, suspend evenly, and then place the mixture in the pressure-resistant container Under pressure, the medicinal liquid is filled into the aerosol cans with the caps pressed through the valve, and each can is 10ml, so that 10 bottles of aerosols are obtained. The volume of each bottle of aerosol is 10ml, containing 4.8mg of medicine. The aerosol quantitative valve releases 100 μl of medicine per release, containing 48 μg of BCG polysaccharide ...

Embodiment 2

[0056] Embodiment 2: a kind of BCG polysaccharide nucleic acid inhalation aerosol, prescription is:

[0057]

[0058] According to the prescription amount, micronized BCG polysaccharide nucleic acid 0.072g, surfactant sorbitan trioleate 1.5g, propellant 1,1,1,2,3,3,3-heptafluoropropane 100ml, in Suspend evenly in a pressure-resistant container at -30°C, then add 0.04 g of preservative methyl paraben, suspend, and then fill the liquid medicine in the pressure-resistant container into the aerosol with the cap pressed through the valve under pressure In each can, add 10ml of medicinal solution to obtain 10 bottles of aerosol. The volume of each bottle of aerosol is 10ml, containing 7.2mg of medicine. The aerosol quantitative valve releases 100 μl of medicine per release, containing 72 μg of BCG polysaccharide nucleic acid. The total number of times per bottle is 100.

Embodiment 3

[0059] Embodiment 3: a kind of production method of BCG polysaccharide nucleic acid inhalation aerosol, prescription is:

[0060]

[0061] According to the prescription amount, dissolve 1.0 g of surfactant sorbitan trioleate in 8 ml of absolute ethanol as a co-solvent, then add 0.048 g of micronized BCG polysaccharide nucleic acid, stir for 12 hours, and then pour into the solution Add 92ml of propellant 1,1,1,2-tetrafluoroethane, and suspend evenly in a pressure-resistant container at -30°C, then add 0.04g of preservative propylparaben, suspend, and then put it in a pressure-resistant container The medicinal liquid is filled under pressure through a valve into the aerosol cans that have been pressed and covered, and 10ml of medicinal liquid is added to each can to obtain 10 bottles of aerosol. The volume of each bottle of aerosol is 10ml, containing 4.8mg of medicine. The aerosol quantitative valve releases 100 μl of medicine per release, containing 48 μg of BCG polysacch...

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Abstract

The invention discloses a bacilli calmette-gurin polysaccharide nucleic acid inhalation aerosol and a preparation method and an application thereof. The aerosol consists of bacilli calmette-gurin polysaccharide nucleic acid, a propellant, a cosolvent, a surfactant and a preservative, wherein the propellant is prepared from 1,1,1,2-tetrafluoroethane and 1,1,1,2,3,3,3-heptafluoropropane. The aerosol is prepared with a pressure filling method or a cover filling method and the like; and an aerosol tank is provided with a quantifying valve which can be used for quantitatively releasing a medicament. Due to the adoption of the bacilli calmette-gurin polysaccharide nucleic acid inhalation aerosol provided by the invention, the bacilli calmette-gurin polysaccharide nucleic acid can be directly distributed into nasal cavities, trachea, bronchus and lungs, and is taken as a medicament for treating allergic asthma / or allergic rhinitis.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and more specifically relates to a quantitative inhalation aerosol of BCG polysaccharide nucleic acid, a preparation method and an application. Background technique [0002] Aerosol means that the drug-containing solution, emulsion or suspension is packed together with a suitable propellant in a pressure-resistant container with a special valve system, and the contents are sprayed out in the form of mist by the pressure of the propellant during use. , for lung inhalation or direct spray to cavity mucous membrane, skin and space disinfection preparations. According to the route of administration, it can be divided into inhalation aerosol, non-inhalation aerosol and external aerosol; according to the composition of the prescription, it can be divided into two-phase aerosol (gas phase and liquid phase) and three-phase aerosol (gas phase, liquid phase) , solid phase or liquid pha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K35/74A61K31/715A61P11/06A61P11/02A61P37/08
Inventor 孙隆儒刘安昌翟光喜马铭怿
Owner SHANDONG UNIV