Application of ixeris sonchifolia hance injection in preparing medicine for treating dementia

A technology of injection and Kudiezi, which is applied in the field of preparation of drugs for the treatment of dementia, can solve the problems of unreported application of drugs for the treatment of dementia, and achieve the effects of improving brain microcirculation, lowering blood lipids, and reducing oxidative damage

Active Publication Date: 2012-08-08
TONGHUA HUAXIA PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] Studies have reported that Kudiezi injection is also suitable for patients with fundus disease, pneumonia, anti-virus, and anti-herpes simplex virus symptoms, but its application in the treatment of dementia drugs has not been reported

Method used

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  • Application of ixeris sonchifolia hance injection in preparing medicine for treating dementia
  • Application of ixeris sonchifolia hance injection in preparing medicine for treating dementia
  • Application of ixeris sonchifolia hance injection in preparing medicine for treating dementia

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Effect test

experiment example

[0024] Effect of Kudiezi Injection on Dementia Rats Induced by Intracerebral Injection of Aβ

[0025] 1. Experimental materials

[0026] 1. Drugs and reagents Test drug Kudiezi injection: provided by Jilin Tonghua Huaxia Pharmaceutical Co., Ltd., injection, 10ml / bottle; positive drug, Haperin (Huperzine A tablet): provided by Henan Zhulin Zhongsheng Pharmaceutical Co., Ltd. Produced by Yuzhong Pharmaceutical Co., Ltd.; Aβ 1-40 : purchased from Sigma Company.

[0027] 2. Experimental animals Wistar rats, male, 180-220 g, provided by Shanghai Slack Company.

[0028] 2. Experimental method

[0029] 1. Dose determination

[0030] According to the clinical dosage of 10-40ml / day / person, the usual dosage is 30-40ml / day / person, and the estimated dosage for rats is 5ml / kg. kg three doses. Since the low doses in the last test all showed a certain curative effect, the dose of this test was lowered, and three doses of 1.25, 2.5, and 5ml / kg were set, the administration volume was 2ml...

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Abstract

The invention relates to a new application of a preparation of Chinese medicine, namely, an application of an ixeris sonchifolia hance injection in preparing a medicine for treating dementia. The ixeris sonchifolia hance injection can be directly injected into the body of a dementia patient. According to a test for effect of ixeris sonchifolia hance injection to A-beta intracerebral injection induced dementia rat, a test result shows that the function of protecting neuron is achieved by the ixeris sonchifolia hance by increasing brain blood volume, improving the brain microcirculation, enhancing the A-beta metabolism and reducing the A-beta deposition in an injection area, and meanwhile, the function of protecting neuron is achieved by the ixeris sonchifolia hance by reducing blood fat, protecting cardiovascular health and reducing A-beta induced oxidative damage. The invention discloses a new medicinal application of the ixeris sonchifolia hance injection; the adaptation disease of the ixeris sonchifolia hance injection is increased; and the ixeris sonchifolia hance injection has a curative effect on dementia diseases.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine preparation, that is, the application of Kudiezi injection in the preparation of medicaments for treating dementia. Background technique [0002] In the prior art, "Dictionary of Chinese Medicine" April 2004 edition first book records: Ixeris sonchifolia Hance (also known as Kudiezi) is a perennial herb of Compositae, and the whole herb is used as medicine. The whole herb contains flavonoids, which have the effects of analgesia, sedation, and smooth muscle spasm relief. It also has the effects of clearing heat and detoxification, cooling blood, promoting blood circulation, and draining concentration, and has a certain anti-inflammatory effect. Astragalus is a perennial herb, the plant form is a perennial herb, the plant height is 70-80cm, the taller can be about 100cm, the main stem is 0.3-0.5cm thick, and the branches are 0.1-0.3cm. [0003] Kudiezi injection (former name: D...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P25/28
Inventor 华玉强
Owner TONGHUA HUAXIA PHARMA
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