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Compound preparation of quetiapine fumarate and lurasidone

A technology of quetiapine fumarate and compound preparations, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., can solve problems such as extrapyramidal adverse reactions and excessive dosage, and achieve good results. Effects of drug synergy, reduction of side effects, and increase in treatment compliance

Active Publication Date: 2013-10-16
NANJING ZENKOM PHARMA
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  • Claims
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Problems solved by technology

[0006] The object of the present invention is to provide a compound preparation of quetiapine fumarate and lurasidone, which solves the problem of excessive dosage of quetiapine fumarate and lurasidone in combination alone, extrapyramidal system (EPS) Defects of Adverse Reactions

Method used

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  • Compound preparation of quetiapine fumarate and lurasidone
  • Compound preparation of quetiapine fumarate and lurasidone
  • Compound preparation of quetiapine fumarate and lurasidone

Examples

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Embodiment 1

[0019] The preparation of embodiment 1 tablet

[0020]

[0021]

[0022] Preparation process: Mix quetiapine fumarate, lurasidone and auxiliary materials microcrystalline cellulose and sodium carboxymethyl cellulose evenly, add appropriate amount of starch slurry to make a soft material, and then granulate through a 16-mesh sieve. The wet granules are dried at 60°C, the dry granules are passed through a 16-mesh sieve for granulation, the fine powder in the dry granules is screened out, mixed with magnesium stearate, and then mixed with the dry granules, compressed into tablets, and obtained.

[0023] Clinical application of quetiapine fumarate combined with lurasidone in anti-schizophrenia

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Abstract

The invention discloses a compound preparation of quetiapine fumarate and lurasidone, which is used for treating schizophrenia. Each preparation unit contains the quetiapine fumarate with the effective dosage of 25-300mg and the lurasidone with the effective dosage of 20-100mg. The dosage of the compound preparation is obviously lower than those of other medicines which are singly used, and the compound preparation has the function of synergy, so that the compound preparation is suitable for severe schizophrenia patients.

Description

technical field [0001] The invention belongs to the field of pharmaceutical manufacturing, in particular to a compound preparation of quetiapine fumarate and lurasidone, which is used for the treatment of schizophrenia. Background technique [0002] Schizophrenia (schizophrenia) is a psychiatric disease. It is a persistent and usually chronic major mental illness. It is the most serious type of mental illness. Environmental disharmony is the most common type of mental illness, and it usually occurs in young and middle-aged people, which in turn affects behavior and emotion. The main symptom of schizophrenia is considered to be a fragmentation of basic thinking structures and cognition. This dissociation creates thought-form disorders and leads to an inability to distinguish between inner and outer experience. People with schizophrenia may report hallucinations themselves, or others may find that their performance is affected by hallucinations. Patients may also express ov...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/554A61K31/496A61P25/18A61P25/28A61P25/24
Inventor 祁艳徐卓业
Owner NANJING ZENKOM PHARMA
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