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Compound omeprazole dry suspension and preparation method thereof

A technology of dry omeprazole and omeprazole is applied in the directions of pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, and can solve the problems of being difficult to take, and having large capsules. Achieve the effect of rapid drug efficacy, low production cost and short production cycle

Inactive Publication Date: 2012-08-22
NANJING HEALTHNICE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is a capsule dosage form of compound omeprazole on the market in foreign countries, the specification of sodium bicarbonate reaches 1.1g / capsule, and the prepared capsules are relatively large, so it is difficult to be suitable for some patients with swallowing disorders and elderly and children patients.

Method used

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  • Compound omeprazole dry suspension and preparation method thereof
  • Compound omeprazole dry suspension and preparation method thereof
  • Compound omeprazole dry suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Prescription:

[0020]

[0021] Preparation process: firstly weigh the prescribed amount of omeprazole, xanthan gum, sucralose and essence and mix; weigh the prescribed amount of sodium bicarbonate and add to the mix; then weigh the prescribed amount of sucrose and add to the mix; finally add the prescribed amount Xylitol, mixed evenly; subpackaged and sealed in bags.

Embodiment 2

[0023] Prescription:

[0024]

[0025] Preparation process: firstly weigh the prescribed amount of omeprazole, xanthan gum, sucralose and essence and mix; weigh the prescribed amount of sodium bicarbonate and add to the mix; then weigh the prescribed amount of sucrose and add to the mix; finally add the prescribed amount Xylitol, mixed evenly; subpackaged and sealed in bags.

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Abstract

The invention relates to compound omeprazole dry suspension and a preparation method thereof. The dry suspension is particularly suitable for patients who have difficulty in taking common oral preparations such as tablets and capsules, old people and child patients. The dry suspension consists of omeprazole, sodium bicarbonate and pharmaceutically acceptable medicinal carrier. Sodium bicarbonate can improve the pH value of the gastric environment and maintain the pH value for certain time, so that the acid-labile omeprazole is quickly absorbed before being destroyed by gastric acid. The dry suspension is characterized in that the granularity of the omeprazole serving as one of main medicament components is controlled in a certain range, so that the prepared omeprazole preparation can be quickly dissolved and absorbed in the gastric environment and quickly and directly achieves an effect of inhibiting secretion of the gastric acid; and when the omeprazole is prepared into the dry suspension, the omeprazole can be uniformly dispersed in the stomach, so that the acting area in the stomach is enlarged, and an ideal curative effect is achieved.

Description

technical field [0001] The invention relates to a dry suspension of compound omeprazole and a preparation method thereof. The preparation is composed of omeprazole, sodium bicarbonate and a pharmaceutically acceptable carrier, and is particularly suitable for taking common oral preparations such as Patients who have difficulties with tablets and capsules, the elderly, and children. Background technique [0002] Omeprazole is a proton pump inhibitor drug used to treat heartburn and other symptoms of gastroesophageal reflux disease, and can also be used for short-term maintenance treatment of duodenal ulcer and reflux esophagitis. Omeprazole inhibits gastric acid secretion by inhibiting the H+ / K+ATPase system on the surface of gastric parietal cells; sodium bicarbonate is weakly alkaline, and it is an antacid in this product, which has the effect of neutralizing gastric acid. [0003] Because omeprazole is easily degraded in gastric acid, the omeprazole preparations currently...

Claims

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Application Information

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IPC IPC(8): A61K33/00A61K9/14A61K47/36A61P1/04A61K31/4439
Inventor 邹巧根王宏响
Owner NANJING HEALTHNICE MEDICAL TECH
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