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Recombinant human interferon alpha2b cream and preparation method thereof

A technology of recombinant human interferon and cream, applied in the directions of ointment delivery, pharmaceutical formulation, emulsion delivery, etc., can solve problems such as being difficult to cure, and achieve the effects of easy coating, easy absorption, and increased curative effect

Active Publication Date: 2014-06-18
ANHUI ANKE BIOTECHNOLOGY (GRP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Condyloma acuminatum caused by human papillomavirus and herpes labialis and genital herpes caused by herpes simplex virus are stubborn skin diseases, which are difficult to be cured by existing cream drugs

Method used

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  • Recombinant human interferon alpha2b cream and preparation method thereof
  • Recombinant human interferon alpha2b cream and preparation method thereof
  • Recombinant human interferon alpha2b cream and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Accurately weigh the oil phase substance, i.e. stearyl alcohol, azone (Azone), the mixture of sorbic acid 2.514kg; water phase substance, polyvinylpyrrolidone (PVP), Tween 80 (TWEEN-80), The mixture of glycerin and water for injection is 2.680kg. The oil phase substance and the water phase substance are subjected to pressure and heat sterilization for 30 minutes at a pressure of 0.05-0.1MPa and a temperature of 120-130°C respectively, and then the oil phase Put the substance in a stirring container and keep stirring, cool to 80°C-90°C and place the stirring container in a constant temperature water bath to keep the temperature constant, then add the water phase substance into the stirring container, and stir for about 2 hours until the two-phase substances are stirred and mixed After uniformity, it becomes a fine white emulsion matrix, and then cooled to 20°C for use.

[0025] Weigh 10.0g of medicinal gelatin and add it to 200ml of slightly heated water for injection in...

Embodiment 2

[0028] Accurately weigh the oil phase substance, i.e. stearyl alcohol, azone (Azone), the mixture of sorbic acid 2.514kg; water phase substance, polyvinylpyrrolidone (PVP), Tween 80 (TWEEN-80), The mixture of glycerin and water for injection is 2.680kg. The oil phase substance and the water phase substance are subjected to pressure and heat sterilization for 30 minutes at a pressure of 0.05-0.1MPa and a temperature of 120-130°C respectively, and then the oil phase Put the substance in a stirring container and keep stirring, cool to 80°C-90°C and place the stirring container in a constant temperature water bath to keep the temperature constant, then add the water phase substance into the stirring container, and stir for about 2 hours until the two-phase substances are stirred and mixed After uniformity, it becomes a white fine emulsion matrix, and then cooled to 10°C for use.

[0029] Weigh 20g of medicinal gelatin and add it to 200ml of slightly heated water for injection in a...

Embodiment 3

[0032] Accurately weigh the oil phase substance, i.e. stearyl alcohol, azone (Azone), the mixture of sorbic acid 2.514kg; water phase substance, polyvinylpyrrolidone (PVP), Tween 80 (TWEEN-80), The mixture of glycerin and water for injection is 2.680kg. The oil phase substance and the water phase substance are subjected to pressure and heat sterilization for 30 minutes at a pressure of 0.05-0.1MPa and a temperature of 120-130°C respectively, and then the oil phase Put the substance in a stirring container and keep stirring, cool to 80°C-90°C and place the stirring container in a constant temperature water bath to keep the temperature constant, then add the water phase substance into the stirring container, and stir for about 2 hours until the two-phase substances are stirred and mixed After uniformity, it becomes a white fine emulsion matrix, and then cooled to 25°C for use.

[0033] Weigh 60g of medicinal gelatin and add it to 300ml of slightly heated water for injection in a...

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PUM

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Abstract

The invention discloses a recombinant human interferon alpha2b cream, comprising 10-20 mg of recombinant human interferon, 2514g of oil phase substance, 2680g of water phase substance, and 10-60g of pharmaceutical gelatin. The recombinant human interferon alpha2b cream provided by the invention can treat obstinate dermatosis caused by human papilloma virus and herpes simplex virus with good effects. Simultaneously the matrix selected in the invention is a semisolid emulsified by water-oil substances, the matrix has a good affinity for oil and water, so that the recombinant human interferon alpha2b can be well dissolved in the matrix and is convenient for skin to absorb, and the curative effect of the finished pharmaceutical product is further raised, simultaneously exudates on the wound skin can be absorbed, and the matrix is easier to coat, clean and protect skin than greasy matrixes.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a recombinant human interferon α2b cream for treating condyloma acuminatum and herpes and a preparation method thereof. Background technique [0002] Condyloma acuminatum caused by human papillomavirus, herpes labialis and genital herpes caused by herpes simplex virus are all stubborn skin diseases, and it is difficult to cure them with existing cream drugs. Studies have shown that recombinant human interferon α2b has a good effect on human papillomavirus and herpes simplex virus, and can be used to treat genital warts, herpes labialis and genital herpes. Contents of the invention [0003] The object of the present invention is to provide a recombinant human interferon α2b cream, which has a good therapeutic effect on condyloma acuminata caused by human papillomavirus and herpes caused by herpes simplex virus. [0004] In order to achieve the above object, the present invention adopts...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/21A61K9/06A61K47/42A61P31/22A61P31/20
Inventor 宋礼华王荣海倪晓燕储成风
Owner ANHUI ANKE BIOTECHNOLOGY (GRP) CO LTD
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