Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of loxoprofen sodium and a composition is applied in the field of phenylpropionic acid non-steroidal anti-inflammatory drugs, and can solve the problems of poor dispersion uniformity of loxoprofen sodium and the like
Active Publication Date: 2012-09-19
DISHA PHARMA GRP
View PDF3 Cites 4 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0005] The technical problem to be solved in the present invention is: solve the technical problem that loxoprofen sodium dispersion uniformity is not good, provide a kind of loxoprofen sodium dispersion composition that meets Pharmacopoeia regulation, and this composition property is stable
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0027] Features of Example 1: Addition of silicon dioxide.
[0028] Loxoprofen sodium 2H 2 O 68.00g, microcrystalline cellulose 199.0g, crospovidone (XL-10) 15.00g, silicon dioxide 15.00g, magnesium stearate 3.00g, an appropriate amount of 95% ethanol solution. Made: 1000 tablets.
[0029] The preparation method of the composition of the present invention is
[0030] The first step takes loxoprofen sodium and auxiliary materials and passes through a 100-mesh sieve.
[0031] The second step weighs loxoprofen sodium dihydrate, microcrystalline cellulose, silicon dioxide, and crospovidone (XL-10) in the prescription amount in a wet mixing granulator, and dry mixes for 5 minutes to mix evenly , to get a mixture.
[0032] The third step is to add 95% ethanol (about 75g / 1000 tablets) to the mixture to make soft materials.
[0033] The fourth step is to granulate through a 24-mesh sieve.
[0034] The fifth step is to air-dry the wet granules at 60°C until the weight loss is les...
Embodiment 2
[0039] Features of Example 2: Addition of silicon dioxide.
[0040] Loxoprofen sodium 2H 2 O 68.00g, microcrystalline cellulose 199.0g, crospovidone (XL-10) 15.00g, silicon dioxide 9.00g, magnesium stearate 3.00g, an appropriate amount of 95% ethanol solution. Make 1000 pieces by the method for embodiment 1.
Embodiment 3
[0041] Features of Example 3: silicon dioxide internally added.
[0042] Loxoprofen sodium 2H 2 O 68.00g, microcrystalline cellulose 199.0g, crospovidone (XL-10) 15.00g, silicon dioxide 12.00g, magnesium stearate 3.00g, an appropriate amount of 95% ethanol solution. Make 1000 pieces by the method for embodiment 1.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention relates to a loxoprofen sodium composition. Due to the high viscosity of loxoprofen sodium, on one hand, the dispersible tablet of the loxoprofen sodium is easy to clot after being disintegrated, so that the dispersible tablet cannot completely pass through a 2# sieve easily; and on the other hand, the dispersible tablet is easy to absorb moisture, and after the moisture absorption, the tablet is fluffy, the content of the main medicament is decreased, and particularly, the dissolution rate is decreased obviously. According to the loxoprofen sodium composition, a preparation process is changed, and silicon dioxide in the formula is added by an interior addition, so that the composition with high dispersible uniformity and stability is obtained.
Description
[0001] Technical Field The present invention relates to a loxoprofen sodium composition. Background technique [0002] Loxoprofen sodium, chemical name: sodium 2-[4-(2-oxocyclopentylmethyl)phenyl]propionate dihydrate. Belongs to phenylpropionic acid non-steroidal anti-inflammatory drugs. [0003] Loxoprofen sodium was developed by Japan Sankyo Co., Ltd. Compared with similar clinical drugs, loxoprofen sodium has the following characteristics: good clinical effect and small side effects. The other feature is that it has a wide range of indications, and it can be widely used clinically for anti-inflammatory and analgesic treatment of rheumatoid arthritis, low back pain, frozen shoulder, neck, shoulder and wrist syndrome, etc., as well as analgesic and anti-inflammatory treatment after surgery, trauma and tooth extraction And antipyretic and analgesic for acute upper respiratory tract inflammation. Loxoprofen Sodium Dispersible Tablets belong to Category B medical insurance pr...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more