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Acarbose oral solid preparation composition and preparation method thereof

A technology of acarbose and solid preparations, which is applied in the field of medicine, can solve the problems of unsatisfactory powder fluidity and compressibility, and achieve the effects of good long-term storage stability, guaranteed quality, and low moisture absorption and weight gain

Inactive Publication Date: 2012-09-26
BEIJING HANMI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The inventor tried to use the prescription invented by CN100464754C for tablet compression, and found that the fluidity and compressibility of the powder were not ideal

Method used

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  • Acarbose oral solid preparation composition and preparation method thereof
  • Acarbose oral solid preparation composition and preparation method thereof
  • Acarbose oral solid preparation composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]

[0039] Preparation:

[0040] Weigh the prescribed amount of microcrystalline cellulose 102, starch, and pregelatinized starch, and pass through a 30-mesh sieve. Add the prescribed amount of acarbose and colloidal silicon dioxide to a W-100 double-cone mixer (Harbin Nano Pharmaceutical Chemical Equipment Co., Ltd.), and mix evenly (inverter frequency: 35Hz, mixing time: 5min) Pass through a 30-mesh sieve, add microcrystalline cellulose 102, starch, and pregelatinized starch and mix evenly (inverter frequency: 35Hz, mixing time: 60min), and finally add magnesium stearate and mix evenly (inverter frequency: 35Hz, mixing time : 5min), compressed into tablets.

Embodiment 2

[0042]

[0043]

[0044] Preparation method: with embodiment 1.

Embodiment 3

[0046]

[0047] Preparation method: with embodiment 1.

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Abstract

The invention relates to the field of medicines, and discloses an acarbose oral solid preparation composition and a preparation method thereof. The acarbose oral solid preparation composition disclosed by the invention is composed of acarbose, a filler and a lubricant, wherein the powder flowability and compressibility of the acarbose oral solid preparation composition are greatly enhanced, and the prepared solid preparation is lower in moisture absorption and better in stability, and has a good industrial application prospect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an acarbose oral solid preparation composition and a preparation method thereof. Background technique [0002] Acarbose belongs to the class of α-glucosidase inhibitors. It is a compound oligomeric four-carbon sugar that can competitively inhibit the α-glucosidase of small intestinal intestinal brush border cells, reduce the decomposition of polysaccharides and sucrose into glucose, and delay The hydrolysis and absorption of disaccharides and polysaccharides can effectively reduce postprandial blood sugar. Acarbose directly lowers postprandial blood sugar by delaying the absorption of carbohydrates in the intestinal tract. This unique mechanism not only can effectively reduce HbA1c in monotherapy, which is comparable to sulfonylureas or metformin, but also can It can be safely and effectively used in combination with other hypoglycemic drugs. For patients who use insulin, the combined us...

Claims

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Application Information

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IPC IPC(8): A61K31/702A61K47/12A61K47/04A61K9/20A61P3/10
Inventor 张明王书典万英杨慧君成仁基
Owner BEIJING HANMI PHARMA CO LTD
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