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Sodium hyaluronate eye drops and a preparation method thereof
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A technology of sodium hyaluronate and eye drops, applied in the field of medicine, can solve the problems of easily contaminated bacteria and the like, and achieve the effects of stable and feasible preparation process, good stability and promotion of healing
Active Publication Date: 2012-10-03
ZHEJIANG JIANFENG PHARM CO LTD
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[0018] In order to solve the technical defects of the stability of sodium hyaluronate and the tendency to be contaminated and grow bacteria, an object of the present invention is to provide a sodium hyaluronate eye drop, which has good antibacterial performance and good stability specialty
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Embodiment 1
[0068] Sodium hyaluronate eye drops, each 100ml consists of the following components:
[0073] Borneol 10mg, add water for injection to 100ml.
[0074] The preparation method of above-mentioned sodium hyaluronate eye drops, comprises the following steps:
[0075] 1) Take 50% of the prepared water for injection in advance and cool it to 50~60°C and pour it into the mixing bucket, accurately weigh the sodium hyaluronate, add the sodium hyaluronate while stirring, soak until completely dissolved;
[0076] 2) Take 30% of the prepared water for injection and put it in a stainless steel bucket, accurately weigh boric acid, borax, disodium edetate, 6-aminocaproic acid, mannitol, and sodium chloride, and add them into the stainless steel bucket in sequence , after stirring an...
Embodiment 2
[0084] Sodium hyaluronate eye drops, each 100ml consists of the following components:
[0097] Borneol 12mg, add water for injection to 100ml.
[0098] The preparation method is shown in Example 1.
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Abstract
The invention relates to the field of medicine and particularly relates to sodium hyaluronate eye drops and preparation method thereof. Every 100 ml of the sodium hyaluronate eye drops comprise the following components: 80 to 150 mg of sodium hyaluronate, 130 to 200 mg of boric acid, 10 to 20 mg of borax, 8 to 15 mg of edetate disodium, 80 to 160 mg of 6-amino caproic acid, 80 to 160 mg of mannitol, 600 to 800 mg of sodium chloride, 3 to 10 mg of benzalkonium chloride, and 8 to 15 mg of borneo camphor, wherein 100 ml of water for injection is added, and the pH value is regulated to 6.0 to 7.8. The eye drops provided by the invention can play the role of promoting healing of injuries of corneal epithelium, can prolong the break-up time remarkably and can better improve the symptoms of xerophthalmia. Meanwhile, the sodium hyaluronate eye drops have good stability at ambient temperature, and all figures are similar, which indicates that the preparation technology is steady and practicable; and if the eye drops are used within the available period, the indexes of HA-Na are all within the quality control range.
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