Sodium hyaluronate eye drops and a preparation method thereof
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A technology of sodium hyaluronate and eye drops, applied in the field of medicine, can solve the problems of easily contaminated bacteria and the like, and achieve the effects of stable and feasible preparation process, good stability and promotion of healing
Active Publication Date: 2012-10-03
ZHEJIANG JIANFENG PHARM CO LTD
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[0018] In order to solve the technical defects of the stability of sodium hyaluronate and the tendency to be contaminated and grow bacteria, a...
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Embodiment 1
[0068] Sodium hyaluronate eye drops, each 100ml consists of the following components:
[0073] Borneol 10mg, add water for injection to 100ml.
[0074] The preparation method of above-mentioned sodium hyaluronate eye drops, comprises the following steps:
[0075] 1) Take 50% of the prepared water for injection in advance and cool it to 50~60°C and pour it into the mixing bucket, accurately weigh the sodium hyaluronate, add the sodium hyaluronate while stirring, soak until completely dissolved;
[0076] 2) Take 30% of the prepared water for injection and put it in a stainless steel bucket, accurately weigh boric acid, borax, disodium edetate, 6-aminocaproic acid, mannitol, and sodium chloride, and add them into the stainless steel bucket in sequence , after stirring an...
Embodiment 2
[0084] Sodium hyaluronate eye drops, each 100ml consists of the following components:
[0097] Borneol 12mg, add water for injection to 100ml.
[0098] The preparation method is shown in Example 1.
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Abstract
The invention relates to the field of medicine and particularly relates to sodium hyaluronate eye drops and preparation method thereof. Every 100 ml of the sodium hyaluronate eye drops comprise the following components: 80 to 150 mg of sodium hyaluronate, 130 to 200 mg of boric acid, 10 to 20 mg of borax, 8 to 15 mg of edetate disodium, 80 to 160 mg of 6-amino caproic acid, 80 to 160 mg of mannitol, 600 to 800 mg of sodium chloride, 3 to 10 mg of benzalkonium chloride, and 8 to 15 mg of borneo camphor, wherein 100 ml of water for injection is added, and the pH value is regulated to 6.0 to 7.8. The eye drops provided by the invention can play the role of promoting healing of injuries of corneal epithelium, can prolong the break-up time remarkably and can better improve the symptoms of xerophthalmia. Meanwhile, the sodium hyaluronate eye drops have good stability at ambient temperature, and all figures are similar, which indicates that the preparation technology is steady and practicable; and if the eye drops are used within the available period, the indexes of HA-Na are all within the quality control range.
Description
technical field [0001] The invention relates to the field of medicine, in particular to sodium hyaluronate eye drops and a preparation method thereof. Background technique [0002] Sodium hyaluronate, also known as sodium hyaluronate (sodium Hyaluronate, HA-Na), is an acidic mucopolysaccharide macromolecule prepared by cockscomb extraction or microbial fermentation, with a molecular weight of about 800,000-2.5 million. It is composed of N-acetylglucosamine and glucose Sodium aldolate is a linear macromolecule formed by the polymerization of disaccharide units. Sodium hyaluronate is a physiologically active substance widely present in the human body. It is distributed in the vitreous body of the eye, aqueous humor, skin, joint synovial fluid, umbilical cord, etc., and plays a role in lubrication, water retention, buffering, viscoelasticity, wound repair, and network fixation. and regulation of cells. [0003] Sodium hyaluronate can be used as a filler in ophthalmic surgery,...
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