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Sodium hyaluronate eye drops and a preparation method thereof

A technology of sodium hyaluronate and eye drops, applied in the field of medicine, can solve the problems of easily contaminated bacteria and the like, and achieve the effects of stable and feasible preparation process, good stability and promotion of healing

Active Publication Date: 2012-10-03
ZHEJIANG JIANFENG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] In order to solve the technical defects of the stability of sodium hyaluronate and the tendency to be contaminated and grow bacteria, an object of the present invention is to provide a sodium hyaluronate eye drop, which has good antibacterial performance and good stability specialty

Method used

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  • Sodium hyaluronate eye drops and a preparation method thereof
  • Sodium hyaluronate eye drops and a preparation method thereof
  • Sodium hyaluronate eye drops and a preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0068] Sodium hyaluronate eye drops, each 100ml consists of the following components:

[0069] Sodium Hyaluronate 100mg, Boric Acid 150mg,

[0070] Borax 12mg, Edetate Disodium 10mg,

[0071] 6-aminocaproic acid 100mg, mannitol 100mg,

[0072] Sodium Chloride 700mg, Benzalkonium Chloride 5mg,

[0073] Borneol 10mg, add water for injection to 100ml.

[0074] The preparation method of above-mentioned sodium hyaluronate eye drops, comprises the following steps:

[0075] 1) Take 50% of the prepared water for injection in advance and cool it to 50~60°C and pour it into the mixing bucket, accurately weigh the sodium hyaluronate, add the sodium hyaluronate while stirring, soak until completely dissolved;

[0076] 2) Take 30% of the prepared water for injection and put it in a stainless steel bucket, accurately weigh boric acid, borax, disodium edetate, 6-aminocaproic acid, mannitol, and sodium chloride, and add them into the stainless steel bucket in sequence , after stirring an...

Embodiment 2

[0084] Sodium hyaluronate eye drops, each 100ml consists of the following components:

[0085] Sodium Hyaluronate 90mg, Boric Acid 110mg,

[0086]Borax 12mg, Edetate Disodium 10mg,

[0087] 6-aminocaproic acid 100mg, mannitol 90mg,

[0088] Sodium Chloride 700mg, Benzalkonium Chloride 5mg,

[0089] Borneol 10mg, add water for injection to 100ml.

[0090] The preparation method is shown in Example 1.

Embodiment 3

[0092] Sodium hyaluronate eye drops, each 100ml consists of the following components:

[0093] Sodium Hyaluronate 140mg, Boric Acid 180mg,

[0094] Borax 18mg, Edetate Disodium 12mg,

[0095] 6-aminocaproic acid 150mg, mannitol 140mg,

[0096] Sodium Chloride 650mg, Benzalkonium Chloride 5mg,

[0097] Borneol 12mg, add water for injection to 100ml.

[0098] The preparation method is shown in Example 1.

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Abstract

The invention relates to the field of medicine and particularly relates to sodium hyaluronate eye drops and preparation method thereof. Every 100 ml of the sodium hyaluronate eye drops comprise the following components: 80 to 150 mg of sodium hyaluronate, 130 to 200 mg of boric acid, 10 to 20 mg of borax, 8 to 15 mg of edetate disodium, 80 to 160 mg of 6-amino caproic acid, 80 to 160 mg of mannitol, 600 to 800 mg of sodium chloride, 3 to 10 mg of benzalkonium chloride, and 8 to 15 mg of borneo camphor, wherein 100 ml of water for injection is added, and the pH value is regulated to 6.0 to 7.8. The eye drops provided by the invention can play the role of promoting healing of injuries of corneal epithelium, can prolong the break-up time remarkably and can better improve the symptoms of xerophthalmia. Meanwhile, the sodium hyaluronate eye drops have good stability at ambient temperature, and all figures are similar, which indicates that the preparation technology is steady and practicable; and if the eye drops are used within the available period, the indexes of HA-Na are all within the quality control range.

Description

technical field [0001] The invention relates to the field of medicine, in particular to sodium hyaluronate eye drops and a preparation method thereof. Background technique [0002] Sodium hyaluronate, also known as sodium hyaluronate (sodium Hyaluronate, HA-Na), is an acidic mucopolysaccharide macromolecule prepared by cockscomb extraction or microbial fermentation, with a molecular weight of about 800,000-2.5 million. It is composed of N-acetylglucosamine and glucose Sodium aldolate is a linear macromolecule formed by the polymerization of disaccharide units. Sodium hyaluronate is a physiologically active substance widely present in the human body. It is distributed in the vitreous body of the eye, aqueous humor, skin, joint synovial fluid, umbilical cord, etc., and plays a role in lubrication, water retention, buffering, viscoelasticity, wound repair, and network fixation. and regulation of cells. [0003] Sodium hyaluronate can be used as a filler in ophthalmic surgery,...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/728A61K47/16A61K47/10A61K47/02A61P27/02A61K31/198A61K31/045
Inventor 蒋晓萌黄金龙殷之武施存元张孝君施小扬
Owner ZHEJIANG JIANFENG PHARM CO LTD
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