High strength injectable hydrogel and preparation method thereof

A hydrogel, high-strength technology, applied in the direction of non-active components of polymer compounds, medical science, prosthesis, etc., can solve the problems of low mechanical strength of hydrogel, achieve injectability, good biodegradability, The effect of increasing strength

Inactive Publication Date: 2012-10-10
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to improve the mechanical properties of natural polymer hydrogel, provide a kind of injection-type high-strength natural polymer hydrogel and preparation method thereof, it is the innovative point of the present invention to use nanoparticle as reinforcing agent, without affecting Under the premise of raw material mixing properties, the compressive strength of natural polymer hydrogels can be greatly improved, so that the defects of low mechanical strength of natural polymer hydrogels can be overcome

Method used

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  • High strength injectable hydrogel and preparation method thereof
  • High strength injectable hydrogel and preparation method thereof
  • High strength injectable hydrogel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0051] (1) Convert 5.0×10 -5 mol PEG (Mw=2000) was dissolved in 100mL of dichloromethane, cooled with ice water, added 0.01mol triethylamine and 0.025mol acryloyl chloride under the protection of nitrogen, and kept stirring. The temperature was raised to room temperature, and the reaction was carried out under nitrogen protection for 12 hours. The final reaction solution was filtered, precipitated, filtered under reduced pressure, and the final product was vacuum-dried at room temperature and collected for future use. This step yielded PEGDA2000.

[0052] (2) Dissolve 1.00g of chitosan (Mn=30,0000) in 100ml of pure water, stir to form a suspension, add 697.2mg (5.16mmol) of HOBt, and stir until the solution is clear. Then add 3.368g (20.64mmol) of NAC, then add 7.914g (41.28mmol) of EDAC·HCL, pass nitrogen, avoid light, and adjust the pH to 5. After stirring and reacting at room temperature for 3 hours, it was dialyzed for three days at 4° C. in the dark, freeze-dried, and s...

Embodiment 2

[0058] (1) Convert 5.0×10 -5 mol PEG (Mw=2000) was dissolved in 100mL of dichloromethane, cooled with ice water, added 0.01mol of triethylamine and 0.02mol of acryloyl chloride under nitrogen protection, and kept stirring. The temperature was raised to room temperature, and the reaction was carried out under nitrogen protection for 12 hours. The final reaction solution was filtered, precipitated, filtered under reduced pressure, and the final product was vacuum-dried at room temperature and collected for future use. This step yielded PEGDA2000.

[0059] (2) Dissolve 1.00g of chitosan (Mn=30,0000) in 100ml of pure water, stir to form a suspension, add 2091.6mg (15.48mmol) of HOBt, and stir until the solution is clear. Then add 1.684g (10.32mmol) of NAC, then add 3.957g (20.64mmol) of EDAC·HCL, pass nitrogen, avoid light, and adjust the pH to 4. After stirring and reacting at room temperature for 5 hours, it was dialyzed for three days at 4° C. in the dark, freeze-dried, and s...

Embodiment 3

[0065] (1) Convert 5.0×10 -5 mol PEG (Mw=2000) was dissolved in 100mL of dichloromethane, cooled with ice water, added 0.02mol triethylamine and 0.025mol acryloyl chloride under the protection of nitrogen, and kept stirring. The temperature was raised to room temperature, and the reaction was carried out under nitrogen protection for 18 hours. The final reaction solution was filtered, precipitated, filtered under reduced pressure, and the final product was vacuum-dried at room temperature and collected for future use. This step yielded PEGDA2000.

[0066] (2) Dissolve 1.00g of chitosan (Mn=30,0000) in 100ml of pure water, stir to form a suspension, add 1045.8mg (7.74mmol) of HOBt, and stir until the solution is clear. Then add 3.368g (22.64mmol) of NAC, then add 7.914g (41.28mmol) of EDAC·HCL, pass nitrogen, avoid light, and adjust the pH to 5. After reacting with stirring at room temperature for 5 hours, it was dialyzed at 4°C in the dark for three days, freeze-dried, and s...

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Abstract

The invention relates to a high strength injectable hydrogel and a preparation method thereof, and specifically relates to the hydrogel formed by using the double bond of polyethyleneglycol diacrylate (PEGDA) and the mercapto group of a sulfhydrylation natural polymer to undergo a Michael addition reaction and at the same time taking the nanoparticles of the triblock copolymer of polyethylene glycol and polycaprolactone (PEG-PCL-PEG) as a reinforcing agent. This kind of hydrogel has relatively high mechanical strength, is injectable hydrogel and degradable hydrogel with good biocompatibility, and has a high gelating speed. The hydrogel has the characteristics of cheap and easily available raw materials and simple preparation method, and therefore has a good application prospect in the biomedical field.

Description

technical field [0001] The present invention relates to a high-strength injectable hydrogel and its preparation method, more specifically, to a Michael Addition reaction, and the hydrogel formed by the triblock copolymer nanoparticles of polyethylene glycol and polycaprolactone (PEG-PCL-PEG) as a reinforcing agent, has high strength and injectability. Background technique [0002] Hydrogel is a three-dimensional polymer swelling that can swell in water, absorb and retain a large amount of water but cannot dissolve in water. Hydrogel is the first biomaterial developed to be used by the human body. When in contact with blood, body fluids and human tissues, it shows good biocompatibility. It neither affects the metabolic process of living organisms nor the metabolites. Can be drained through the hydrogel. Hydrogel is closer to living tissue than any other synthetic biomaterial. It is similar to the extracellular matrix in nature. After absorbing water, it can reduce friction ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/08C08L89/00C08L75/08A61L27/22A61L27/20A61L27/52A61L27/58A61K47/36A61K47/42
Inventor 尹玉姬李钒
Owner TIANJIN UNIV
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