52 results about "Poly ethylene glycol diacrylate" patented technology

The invention relates to a high strength injectable hydrogel and a preparation method thereof, and specifically relates to the hydrogel formed by using the double bond of polyethyleneglycol diacrylate (PEGDA) and the mercapto group of a sulfhydrylation natural polymer to undergo a Michael addition reaction and at the same time taking the nanoparticles of the triblock copolymer of polyethylene glycol and polycaprolactone (PEG-PCL-PEG) as a reinforcing agent. This kind of hydrogel has relatively high mechanical strength, is injectable hydrogel and degradable hydrogel with good biocompatibility, and has a high gelating speed. The hydrogel has the characteristics of cheap and easily available raw materials and simple preparation method, and therefore has a good application prospect in the biomedical field.

The invention provides a preparation method of anti-infection coating. The preparation method comprises the following steps of (a) performing photoinitiator painting treatment on the surfaces of a medical macromolecule material to obtain a base material; (b) placing the base material obtained in the step (a) in a mixed solution comprising adhesion-resistant monomers, pH responsiveness polymerizingmonomers and polyethylene glycol diacrylate, and performing an ultraviolet cross-linking reaction to obtain a material having gel coating on the surface; and (c) performing antibiotic chemical loading on the material having gel coating on the surface obtained in the step (b) so as to obtain the anti-infection coating. According to the preparation method provided by the invention, a specific technology and a specific condition are adopted, and the anti-infection coating is obtained. The anti-infection coating has dual functions of resisting bacterium adhesion and controlling antibiotics to release for sterilization, so that bacterium adhesion can be effectively reduced, controllable release of antibiotics as required can be realized, and the problems that the bacterium-resistant effect ispoor in persistence caused by too fast antibiotic release and bacteria produce drug tolerance caused by random release of the antibiotics can be solved.

The invention provides frame sealant composition, a liquid crystal display unit and a liquid crystal pollution prevention method using the frame sealant composition. The frame sealant composition comprises, by weight, 20-30 parts of ultraviolet double-bond polymeric monomer, 15-20 parts of thermally polymerized monomer, 5-20 parts of polymerizable oligomer, 0.1-5 parts of optical initiator, 10-20 parts of thermal curing agent and 0-20 parts of granulated additive. The polymerizable oligomer is polyethyleneglycol diacrylate or derivatives thereof. The polymerizable oligomer reacts with polymer of the ultraviolet double-bond polymeric monomer to generate network high polymer, and accordingly anchorage of the network high polymer on surrounding unreacted thermally polymerized monomers is enhanced effectively, and pollution of liquid crystal by the frame sealant is reduced.

The invention relates to a preparation method of a nano gold doped integral material for enriching glycoprotein. The preparation method comprises the following steps: taking glycidyl methacrylate (GMA) and polyethylene glycol diacrylate (PEGDA) as the monomers to synthesize a hydrophilic polymer integral material substrate through an in-situ polymerization method; utilizing the epoxy groups in the substrate surface to enrich the substrate surface with mercapto groups through a chemical derivatization method, then modifying the substrate surface with nano gold particles; finally co-modifying 4-mercaptophenylboronic acid and mercaptoethylamine on the nano gold surfaces on the substrate, and enriching glycoprotein on the basis of phenylboronic acid affinity chromatography. The hydrophilicity of the monomer polyethylene glycol diacrylate (PEGDA) is utilized so as to reduce the non-specific adsorption of substrate on proteins, and thus the enrichment selectivity is improved. At the same time, the high specific surface area of nano particles is utilized at the same time, thus the enrichment capacity is increased, and finally the high-efficient and high-selective enrichment of glycoprotein is achieved.

The invention provides a method for preparing temperature-sensitive crosslinked fiber through low-temperature photopolymerization. The temperature-sensitive crosslinked fiber provided by the invention is obtained by carrying out low-temperature photopolymerization reaction on a temperature-sensitive photopolymerization monomer and poly(ethylene oxide) diacrylate under the initiation of a free radical photoinitiator, and can be used as a temperature-sensitive tissue engineering scaffold, intelligent hydrogel and a drug controlled release carrier. The method comprises the steps of dissolving the temperature-sensitive photopolymerization monomer, poly(ethylene oxide) diacrylate and the photoinitiator into water; carrying out low-temperature freezing to freeze water to form a crystal; and then, carrying out low-temperature illuminating and crosslinking as well as freeze drying to remove water to obtain the temperature-sensitive crosslinked fiber. The method has the characteristics of simple preparation process, high speed and capability of finishing material crosslinking and fiber forming processes through one-step reaction.

The invention relates to a QK-polypeptide-encapsulating polylactide copolymer electrospinning fibrous membrane and a preparing method. The preparing method of the polylactide copolymer electrospinning fibrous membrane includes the steps that a fibrous membrane body with the thickness of 50 micrometers to 200 micrometers is formed by polyethylene glycol-b-poly(lactide-co-epsilon-caprolactone) fibers with the diameter of 100 nm to 900 nm or poly(glycolide-co-epsilon-lactide) fibers with the diameter of 100 nm to 900 nm and chitosan gel particles encapsulated in the fibers, wherein the diameter of the chitosan gel particles is smaller than 100 nm; QK polypeptide, sulfhydrylation chitosan and polyethylene glycol 200 diacrylate are dissolved into a phosphate buffer solution to serve as a water phase (W); polylactide copolymers are dissolved into mixed solvents of chloroform and N,N-dimethylformamide to serve as an oil phase (O); the water phase is added into the oil phase, and stirring is carried out to form W / O dispersion liquid under the effect of emulsifying agents; electrospinning is carried out on the dispersing liquid to obtain the fibrous membrane. According to the QK-polypeptide-encapsulating polylactide copolymer electrospinning fibrous membrane and the preparing method, the preparing process is simple, the good biocompatibility and the good degradability are achieved, and the fibrous membrane and the preparing method can be used for the tissue engineering field and the in-situ drug sustained release field.

The invention belongs to the field of nano-drugs, and particularly relates to a synthesis method of a hollow mesoporous silicon dioxide nano-drug capsule. The synthesis method comprises the following steps: modifying hollow mesoporous silicon dioxide through an acrylic acid propyl ester group, dispersing the hollow mesoporous silicon dioxide into a drug-containing buffer solution, then adding polyethylene glycol diacrylate and ammonium persulfate serving as an initiator, and dripping N,N,N',N'-tetramethylethylenediamine serving as an accelerator to enable the polyethylene glycol diacrylate and the acrylic acid propyl ester group to generate polymerization reaction on the surface of the hollow mesoporous silicon dioxide to form a polymer coated layer. Loading of a drug and encapsulation of a nano capsule are completed in the drug-containing buffer solution, so that leakage of the drug in an encapsulation process can be avoided; the synthesis process is simple, and the coating thickness and the compactness can be adjusted.

Disclosed are an alkyl acrylate-aromatic vinyl compound-vinyl cyanide compound copolymer which is prepared using a polyalkylene cross-linking agent such as polyethylene glycol diacrylate or polyethylene glycol dimethacrylate for a core of the alkyl acrylate-aromatic vinyl compound-vinyl cyanide compound copolymer and thus advantageously improves low-temperature impact strength of resins when the copolymer is applied to a polycarbonate resin composition, and the polycarbonate resin composition comprising the copolymer.