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Ophthalmic implanted material with shape memory function and preparation method thereof

An implant material and memory technology, applied in medical science, prosthesis, etc., can solve the problems of many postoperative complications, large implant incision, material can not be filled, etc., and achieve the effect of large material deformation and high light transmittance.

Inactive Publication Date: 2010-07-28
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The object of the present invention is to provide a kind of ophthalmic implant material with shape memory function and preparation method, this material can be used as artificial cornea, intraocular lens, artificial vitreous body, and can overcome the implant existing in existing ophthalmic implant material. The incision is large, the material cannot fill the entire implant cavity, and there are many postoperative complications.

Method used

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  • Ophthalmic implanted material with shape memory function and preparation method thereof
  • Ophthalmic implanted material with shape memory function and preparation method thereof
  • Ophthalmic implanted material with shape memory function and preparation method thereof

Examples

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example 1

[0028] The selected monomers are (a): 2-phenoxyethyl acrylate (Sigma-Aldrich Company), (b): 2-phenoxyethyl methacrylate (Sigma-Aldrich Company). The molar ratio of the selected monomers is a / b=4 / 1, and the molar content of the two is 90.0%. The crosslinking agent is polyethylene glycol diacrylate 400 (Sigma-Aldrich company), and the molar content is 10.0%. %, the content of the added thermal initiator (azobisisobutyronitrile, Shanghai Fourth Chemical Reagent Company) is 0.5% of the total mass. Mix the monomer, cross-linking agent and initiator uniformly under the protection of nitrogen, then pour into the mold, heat and polymerize in an oven at 80°C for 24 hours, perform Soxhlet extraction to remove unreacted monomers and oligomers, and make shape-memory acrylate Material. The refractive index of the material is 1.51, and the transmittance in the visible light region is as follows: figure 2 As shown, the glass transition temperature is 29.5°C, the elastic modulus is 4.07MPa...

example 2

[0030] The selected monomers are (a): 2-phenoxyethyl acrylate (Sigma-Aldrich Company), (b): 2-phenoxyethyl methacrylate (Sigma-Aldrich Company). The selected monomer molar ratio is a / b=4 / 1, and the molar content of the two is 95.0%, and the crosslinking agent is polyethylene glycol diacrylate 1000 (Sigma-Aldrich company), and the molar content is 5.0 %, the content of the added thermal initiator (azobisisobutyronitrile, Shanghai Fourth Chemical Reagent Company) is 0.5% of the total mass. Mix the monomer, cross-linking agent and initiator uniformly under the protection of nitrogen, then pour into the mold, heat and polymerize in an oven at 75°C for 36 hours, perform Soxhlet extraction to remove unreacted monomers and oligomers, and make shape-memory acrylate Material. The refractive index of the material is 1.52, and the transmittance in the visible light region is as follows: Figure 4 As shown, the glass transition temperature is 19.4°C, the elastic modulus is 1.37MPa, the ...

example 3

[0032] The selected monomers are (a): 2-phenoxyethyl acrylate (Sigma-Aldrich Company), (b): lauryl acrylate (Tianjin Tianjiao Chemical Co., Ltd.). The selected monomer molar ratio is a / b=5 / 1, and the molar content of the two is 90.0%, and the crosslinking agent is polyethylene glycol dimethacrylate 600 (Sigma-Aldrich company), and the molar content The content of the thermal initiator (azobisisobutyronitrile, Shanghai Fourth Chemical Reagent Company) added was 0.5% of the total mass of the monomers. Mix the monomer, cross-linking agent and initiator uniformly under the protection of nitrogen, then pour into the mold, heat and polymerize in an oven at 75°C for 24 hours, perform Soxhlet extraction to remove unreacted monomers and oligomers, and make shape-memory acrylate Material. The refractive index of the material is 1.51, and the transmittance in the visible light region is as follows: Figure 5 As shown, the glass transition temperature is 21.2°C, the elastic modulus at r...

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Abstract

The invention relates to an ophthalmic implanted material with the shape memory function and a preparation method thereof, belonging to the field of biomedical materials. Thermally polymerizable acrylate monomers are used as the basic material, and the mol ratio thereof is 10.0-98.0%; polyethylene glycol diacrylates or polyethylene glycol dimethyl acrylates, which have different molecular weights, are used as the cross-linking agent, and the mol ratio thereof is 2.0-90.0%; and thermal initiator accounts for 0.2-1.0% of the total mass. The thermally polymerizable monomers, the thermal initiator and the cross-linking agent are uniformly mixed under the protection of nitrogen gas, then the mixture is injected into a mold to be subject to the thermal polymerization reaction at the temperature of 70-90 DEG C for 24-48 hours, and the Soxhlet extraction is adopted to remove the unreacted monomers and oligomers to obtain the ophthalmic implanted material with the shape memory function. The invention has the advantages that the prepared material has the shape memory property, the memory property transition temperature of the material can be adjusted to the body temperature, and the material has large deformation extent and higher light transmittance in visible light areas.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to an eye implant material and a preparation method thereof, in particular to selecting cross-linking agents with different molecular weights for thermal polymerization to prepare an eye implant material with shape memory function. Background technique [0002] The tissue structure of the eyeball is very fine, and the main function of the ophthalmic implant is to replace the refractive medium of the eyeball and restore visual function. Therefore, the main requirement for ophthalmic implants is to have good transparency and be able to be implanted into the eye through an incision as small as possible, reducing damage to the eyeball. At present, common ocular implants mainly include artificial cornea, intraocular lens, and artificial vitreous body. Implant materials mainly include acrylates, silicone hydrogels, and the like. Among them, acrylates are the most widely used because of...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/50
Inventor 杨槐宋黎王国杰胡望张红斌朱思泉
Owner UNIV OF SCI & TECH BEIJING
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