Sun protection microcapsule taking poly(ethylene glycol) diacrylate as wall material and preparation method thereof

A technology of polyethylene glycol diacrylate and microcapsules, which is applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of microcapsules that have not been reported before, and achieve the improvement of UV protection effect with a simple method Effect

Inactive Publication Date: 2018-05-25
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polyethylene glycol PEG is a non-degradable polymer biomaterial approved by the US FDA. Acrylylated PEG derivatives are often used in the preparation of

Method used

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  • Sun protection microcapsule taking poly(ethylene glycol) diacrylate as wall material and preparation method thereof
  • Sun protection microcapsule taking poly(ethylene glycol) diacrylate as wall material and preparation method thereof
  • Sun protection microcapsule taking poly(ethylene glycol) diacrylate as wall material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] (1) Preparation of oil phase: Add 10 g of homosalate (HMS) into a 100 ml beaker, add 0.1 g of dibenzoyl peroxide (BPO) and stir evenly under heating at 50° C. to obtain an oil phase.

[0032] (2) Preparation of water phase: 10g polyvinyl alcohol (degree of hydrolysis is 88%) powder is joined in the beaker, then add 90g deionized water, stir 2h in 80 ℃ of water baths, make polyvinyl alcohol (degree of hydrolysis is 88%) 88%) was completely dissolved, and made into 10% polyvinyl alcohol aqueous solution as emulsifier solution for subsequent use. 10 g of the above-mentioned 10% polyvinyl alcohol aqueous solution, 2 g of polyethylene glycol diacrylate (molecular weight: 200) and 27.9 g of deionized water were respectively added into a 100 ml beaker, and the water phase was obtained after stirring evenly.

[0033] (3) Preparation of sunscreen microcapsules: Add the water phase (39.9g) in step (2) to the oil phase (10.1g) in step (1), mix the two phases and homogenize for 3mi...

Embodiment 2

[0037] (1) Preparation of the oil phase: 15 g of octyl salicylate was added to a 100 ml beaker, and then 0.1 g of dibenzoyl peroxide (BPO) was added and stirred evenly under heating at 50° C. to obtain the oil phase.

[0038] (2) Preparation of the water phase: Add 10g of polyvinyl alcohol (the degree of hydrolysis is 88%) into a beaker, then add 90g of deionized water, and stir in a water bath at 80°C for 2 hours to completely dissolve the polyvinyl alcohol to obtain 10% polyvinyl alcohol aqueous solution is the emulsifier solution for later use. 7.5 g of the above-mentioned 10% polyvinyl alcohol aqueous solution, 2 g of polyethylene glycol diacrylate (molecular weight: 200) and 25.4 g of deionized water were respectively added into a 100 ml beaker, and the water phase was obtained after stirring evenly.

[0039] (3) Preparation of sunscreen microcapsules: Add the water phase (34.9g) in step (2) to the oil phase (15.1g) in step (1), mix the two phases and homogenize for 3min ...

Embodiment 3

[0042] (1) Preparation of the oil phase: Add 10 g of octocrylene and 5 g of octyl salicylate into a 100 ml beaker, then add 0.1 g of dibenzoyl peroxide (BPO) and stir evenly under heating at 50 ° C to obtain oil Mutually.

[0043] (2) Preparation of the water phase: Add 10g of polyvinyl alcohol (the degree of hydrolysis is 88%) into a beaker, then add 90g of deionized water, and stir in a water bath at 80°C for 2 hours to completely dissolve the polyvinyl alcohol to obtain 10% polyvinyl alcohol aqueous solution is the emulsifier solution for later use. 7.5 g of the above-mentioned 10% polyvinyl alcohol aqueous solution, 2 g of polyethylene glycol diacrylate (molecular weight: 400) and 25.4 g of deionized water were respectively added into a 100 ml beaker, and the water phase was obtained after stirring evenly.

[0044](3) Preparation of sunscreen microcapsules: Add the water phase (34.9g) in step (2) to the oil phase (15.1g) in step (1), mix the two phases and homogenize for ...

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Abstract

The invention relates to a sun protection microcapsule taking poly(ethylene glycol) diacrylate as a wall material and a preparation method thereof. The sun protection microcapsule comprises an oil phase and an aqueous phase, wherein the oil phase comprises the following components in percentage by mass: 5.0-30.0% of a core material and 0.01-0.4% of an initiator; the aqueous phase comprises the following components in percentage by mass: 0.5-3.5% of an emulsifier, 2.0-4.0% of poly(ethylene glycol) diacrylate and 30.8-75.8% of deionized water. The preparation method comprises the following steps: preparing the oil phase, preparing the aqueous phase, and preparing the sun protection microcapsule. The method disclosed by the invention is simple, rapid and capable of preparing uniform microcapsules with different particle sizes; the prepared sun protection microcapsule adopts a white powder in a dry state, can be uniformly dispersed in products, has a wide application range, can be coated with multiple ultraviolet protecting agents and is prevented from being influenced by external environmental factors. The ultraviolet resistance of the ultraviolet protecting agents can be obviously improved.

Description

technical field [0001] The invention belongs to the field of sunscreen products and their preparation, in particular to a sunscreen microcapsule with polyethylene glycol diacrylate as a wall material and a preparation method thereof. Background technique [0002] The harmful effects of different bands of UV rays on the human body have been well described in the literature. In order to reduce the damage caused by skin exposure to the sun's ultraviolet rays, sunscreen products came into being. UV protective agents include physical and chemical types. In order to obtain better sun protection effects, general sunscreen products usually contain high concentrations of these two types of UV protective agents, but most chemical types of ultraviolet rays will cause allergic reactions of varying degrees when they contact the skin. . In recent years, microencapsulation technology has been involved in more and more fields. It can use polymer materials to coat the core material to obta...

Claims

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Application Information

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IPC IPC(8): A61K8/11A61K8/86A61Q17/04
CPCA61K8/11A61K8/86A61Q17/04
Inventor 鲁希华刘天群赵迪李雪婷康圆圆石小迪
Owner DONGHUA UNIV
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