Anti-infection coating and preparation method thereof

An anti-infection and coating technology, which is applied in coating, medical science, surgery, etc., can solve the problems of adhesion and accumulation of dead bacterial debris, inability to inhibit bacterial reproduction for a long time, non-on-demand release of bactericidal substances, etc., to reduce bacteria The risk of infection, reducing bacterial adhesion, solving the effect of poor persistence of antibacterial effect
CN109529128AActive Publication Date: 2019-03-29CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
7 Cites 27 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Publication Date
2019-03-29

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides a preparation method of anti-infection coating. The preparation method comprises the following steps of (a) performing photoinitiator painting treatment on the surfaces of a medical macromolecule material to obtain a base material; (b) placing the base material obtained in the step (a) in a mixed solution comprising adhesion-resistant monomers, pH responsiveness polymerizingmonomers and polyethylene glycol diacrylate, and performing an ultraviolet cross-linking reaction to obtain a material having gel coating on the surface; and (c) performing antibiotic chemical loading on the material having gel coating on the surface obtained in the step (b) so as to obtain the anti-infection coating. According to the preparation method provided by the invention, a specific technology and a specific condition are adopted, and the anti-infection coating is obtained. The anti-infection coating has dual functions of resisting bacterium adhesion and controlling antibiotics to release for sterilization, so that bacterium adhesion can be effectively reduced, controllable release of antibiotics as required can be realized, and the problems that the bacterium-resistant effect ispoor in persistence caused by too fast antibiotic release and bacteria produce drug tolerance caused by random release of the antibiotics can be solved.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the technical field of medical materials, in particular to an anti-infection coating and a preparation method thereof. Background technique

[0002] Pathogens have been a serious threat to human health for a long time. Studies have shown that the formation of biofilm by bacteria on the surface of materials is an important cause of bacterial infection and bacterial drug resistance. Phytoplankton bacteria continue to reproduce, differentiate and spread after irreversible attachment on the surface of the material, and finally form a biofilm. Compared with planktonic bacteria, the tolerance of bacteria in biofilm to fungicides can be increased by more than 10-1000 times.

[0003] According to the above-mentioned characteristics of bacteria, in the prior art, passive anti-adhesion and active bactericidal functional surfaces are usually constructed to effectively prevent bacterial infection. Among them, the passive anti-adhesion s...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More