Anti-infection coating and preparation method thereof

Abstract

The invention provides a preparation method of anti-infection coating. The preparation method comprises the following steps of (a) performing photoinitiator painting treatment on the surfaces of a medical macromolecule material to obtain a base material; (b) placing the base material obtained in the step (a) in a mixed solution comprising adhesion-resistant monomers, pH responsiveness polymerizingmonomers and polyethylene glycol diacrylate, and performing an ultraviolet cross-linking reaction to obtain a material having gel coating on the surface; and (c) performing antibiotic chemical loading on the material having gel coating on the surface obtained in the step (b) so as to obtain the anti-infection coating. According to the preparation method provided by the invention, a specific technology and a specific condition are adopted, and the anti-infection coating is obtained. The anti-infection coating has dual functions of resisting bacterium adhesion and controlling antibiotics to release for sterilization, so that bacterium adhesion can be effectively reduced, controllable release of antibiotics as required can be realized, and the problems that the bacterium-resistant effect ispoor in persistence caused by too fast antibiotic release and bacteria produce drug tolerance caused by random release of the antibiotics can be solved.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to an anti-infection coating and a preparation method thereof. Background technique [0002] Pathogens have been a serious threat to human health for a long time. Studies have shown that the formation of biofilm by bacteria on the surface of materials is an important cause of bacterial infection and bacterial drug resistance. Phytoplankton bacteria continue to reproduce, differentiate and spread after irreversible attachment on the surface of the material, and finally form a biofilm. Compared with planktonic bacteria, the tolerance of bacteria in biofilm to fungicides can be increased by more than 10-1000 times. [0003] According to the above-mentioned characteristics of bacteria, in the prior art, passive anti-adhesion and active bactericidal functional surfaces are usually constructed to effectively prevent bacterial infection. Among them, the passive anti-adhesion s...

AI Technical Summary

Problems solved by technology

Among them, the passive anti-adhesion surface mainly uses substances with anti-adhesion function, such as polyethylene glycol, amphoteric inner salt, etc., to reduce the surface adhesion of bacteria or interfere with the formation of biofilm to inhibit bacterial infection; however, this method It can only slow down the adhesion of bacteria in the short term, but cannot inhibit the reproduction of bacteria in the long term

The active bactericidal surface usually uses physical loading or chemical bonding methods to fix conventional antibacterial agents, such as antibiotics, silver ions, and chitosan, to the surface of the substrate material, and realizes the bactericidal function through release; however, purely chemically bonded bactericides The active sterilizing surface is easy to cause the adhesion and accumulation of dead bacterial debris, thereby causing subsequent bacterial adhesion, proliferation and infection, while the surface of the physical loading method has problems such as non-on-demand release of bactericidal substances and too fast release of bactericidal substances, which often lead to antibacterial Poor effect persistence, short shelf life, and due to the irregular release of antibiotics, it is easy to induce bacteria to develop bacterial resistance

Images