Sunscreen microcapsule taking polyethylene glycol diacrylate and preparation method thereof

A technology of polyethylene glycol diacrylate and microcapsules, which is applied in skin care preparations, medical preparations containing active ingredients, and pharmaceutical formulations, can solve the problems of low-safety chemical UV sunscreens, and achieve Good biocompatibility, reduce skin damage, good anti-ultraviolet effect

Inactive Publication Date: 2018-08-21
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The problem to be solved by the present invention is: the problem that the existing sunscreen products mostly use chemical ultraviolet sunscreens with low safety

Method used

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  • Sunscreen microcapsule taking polyethylene glycol diacrylate and preparation method thereof
  • Sunscreen microcapsule taking polyethylene glycol diacrylate and preparation method thereof
  • Sunscreen microcapsule taking polyethylene glycol diacrylate and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A preparation method of sunscreen microcapsules using polyethylene glycol diacrylate as wall material:

[0034] (1) Preparation of oil phase

[0035] Weigh 5g of octyl salicylate into a 100mL beaker, add 0.1g of dibenzoyl peroxide (BPO) and heat and stir at 50°C to evenly serve as the oil phase.

[0036] (2) Configuration of the water phase:

[0037] Weigh 10 g of gum arabic powder into a beaker, add 90 g of deionized water, and stir in a water bath at 80°C for 2 hours to completely dissolve the gum arabic, and prepare a 10% aqueous solution of gum arabic as an emulsifier solution for later use. Add 7.5g of the above-mentioned 10% gum arabic aqueous solution, 1g of polyethylene glycol diacrylate (200) and 36.4g of deionized water into a 100mL beaker, stir evenly to obtain an aqueous phase.

[0038] (3) Preparation of emulsion

[0039] The water phase is added to the oil phase, and after the two phases are mixed, they are homogenized under the action of a high-speed h...

Embodiment 2

[0043] A preparation method of sunscreen microcapsules using polyethylene glycol diacrylate as wall material:

[0044] (1) Preparation of oil phase

[0045] Weigh 15g of octyl salicylate into a 100mL beaker, add 0.1g of dibenzoyl peroxide (BPO) and heat and stir at 50°C to evenly serve as the oil phase.

[0046] (2) Configuration of the water phase:

[0047] Weigh 10 g of polyvinyl alcohol (88% degree of hydrolysis) into a beaker, add 90 g of deionized water, stir at 80° C. for 2 h to completely dissolve the polyvinyl alcohol, and prepare a 10% polyvinyl alcohol solution as an emulsifier solution for later use. Add 7.5g of the above-mentioned 10% polyvinyl alcohol solution, 2g of polyethylene glycol diacrylate (200) and 25.4g of deionized water into a 100mL beaker, stir evenly to obtain an aqueous phase.

[0048] (3) Preparation of emulsion

[0049] The water phase is added to the oil phase, and after the two phases are mixed, they are homogenized under the action of a high...

Embodiment 3

[0054] A preparation method of sunscreen microcapsules using polyethylene glycol diacrylate as wall material:

[0055] (1) Preparation of oil phase

[0056] Weigh 10 g of octocrylene and 5 g of octyl salicylate into a 100 mL beaker, add 0.1 g of dibenzoyl peroxide (BPO) and heat and stir at 50° C. to evenly serve as the oil phase.

[0057] (2) Configuration of the water phase:

[0058] Weigh 10 g of polyvinyl alcohol (88% degree of hydrolysis) into a beaker, add 90 g of deionized water, stir at 80° C. for 2 h to completely dissolve the polyvinyl alcohol, and prepare a 10% polyvinyl alcohol solution as an emulsifier solution for later use. Add 7.5g of the above 10% polyvinyl alcohol solution, 2g of polyethylene glycol diacrylate (400) and 25.4g of deionized water into a 100mL beaker, stir evenly to obtain an aqueous phase.

[0059] (3) Preparation of emulsion

[0060] The water phase is added to the oil phase, and after the two phases are mixed, they are homogenized under the ...

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Abstract

The invention discloses a sunscreen microcapsule taking polyethylene glycol diacrylate as a wall material and a preparation method of the sunscreen microcapsule. The microcapsule comprises the raw materials of a core material, an initiator, an emulsifying agent, polyethylene glycol diacrylate, and deionized water. The preparation method is as follows: using the emulsifying agent and part of deionized water to prepare an emulsifying agent aqueous solution, mixing the emulsifying agent aqueous solution, polyethylene glycol diacrylate and the rest of the deionized water to obtain an aqueous phase; mixing the core material and the initiator, evenly mixing under the heating condition to obtain an oil phase; adding the aqueous phase into the oil phase, shearing, forming an emulsion; introducingnitrogen into the emulsion, mechanically stirring, reacting to obtain the microcapsule. The polyethylene glycol diacrylate macromolecule is taken as a monomer, the monomer is non-toxic, is excellent in biocompatibility, contains two double bonds, and is crosslinked under the action of the initiator to form a three-dimensional network high polymer, so that the core material is wrapped to form the sunscreen microcapsule, and the side effect caused by the direct contact between the skin and a chemical ultraviolet protecting agent is reduced.

Description

technical field [0001] The invention relates to a sunscreen microcapsule with polyethylene glycol diacrylate as a wall material and a preparation method thereof, belonging to the technical field of microcapsule preparation. Background technique [0002] The harmful effects of different bands of UV rays on the human body have been well described in the literature. In order to reduce the damage caused by skin exposure to the sun's ultraviolet rays, sunscreen products came into being. UV protective agents include physical and chemical types. In order to obtain better sun protection effects, general sunscreen products usually contain high concentrations of these two types of UV protective agents, but most chemical types of ultraviolet rays will cause allergic reactions of varying degrees when they contact the skin. . In recent years, microencapsulation technology has been involved in more and more fields. It can use polymer materials to coat the core material to obtain microca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/11A61K8/86A61K8/37A61Q17/04
CPCA61K8/11A61K8/37A61K8/86A61K2800/412A61Q17/04
Inventor 鲁希华刘天群赵迪李雪婷康圆圆
Owner DONGHUA UNIV
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