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Medicinal composition for treating gynecological inflammations

A technology of gynecological inflammation and composition, applied in the field of pharmaceutical compositions, can solve problems such as the effect is not very significant

Inactive Publication Date: 2012-10-17
苏州瑞美科生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] But the inventor finds that when using chitosan oligosaccharide alone to treat wounds, its effect is not very significant

Method used

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  • Medicinal composition for treating gynecological inflammations
  • Medicinal composition for treating gynecological inflammations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 pharmaceutical composition preparation

[0015] The raw materials of the pharmaceutical composition are obtained commercially.

[0016] Oligochitosan Purity > 98% Polymerization < 10

[0017] Danshen Extract The total ketone content of Danshen > 98%

[0018] Angelica extract Lactone content 1%, ferulic acid 0.8%

[0019] Astragalus extract 0.75g / 10ml

[0020] Take a 200ml beaker, add 100ml of depyrogenated distilled water, then add 5g chitosan oligosaccharide, 1g salvia miltiorrhiza extract, 0.65g angelica extract, 0.75g astragalus extract, boil for 5min, then cool to room temperature (25°C), filter out Remove the insoluble matter to obtain the coating agent.

[0021] The pharmaceutical composition prepared in Example 1 was used in the following tests.

[0022] 1. Acute toxicity test

[0023] Test animals: 70 Kunming mice, weighing 17-22g, half male and half male. Purchased from Shanghai Skyline Experimental Animal Co., Ltd.

[0024] Grouping of ani...

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Abstract

The invention discloses a medicinal composition for treating gynecological inflammations. The medicinal composition is characterized in that the medicinal composition comprises the following components, by weight, 5 parts of a chitosan oligosaccharide, 1 part of a Salvia miltiorrhiza extract, 0.65 parts of a Chinese angelica extract paste, and 0.75 parts of a Radix Astragali extract liquid. The medicinal composition of the invention is applied to wound restoration experiments, and results show that wounds are basically healed and there are no obvious scars. Cell proliferation tests prove that the medicinal composition is good for cell propagation and regeneration. The medicinal composition is applied to in vitro bacteriostatic tests, and results show that the medicinal composition has a stronger bacteriostatic capability than Anfushu, Ruchuangning and wound restoration agents. Acute toxicity tests of the medicinal composition are carried out in the invention, and the test medicinal composition is regarded as a nontoxic medicine through determining according to acute toxicity grading standards. So the medicinal composition of the invention can be used for treating the gynecological inflammations, and has large clinical application values.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating gynecological inflammation. Background technique [0002] At present, based on the research on chitosan oligosaccharide, it has been reported that it has various functions such as antibacterial, antitumor, regulating blood lipid, regulating immunity and promoting wound repair. Because oligochitosan has a good affinity for cells, oligochitosan itself is an indispensable component in the sugar chain structure on the surface of the cell membrane, and plays the roles of intercellular recognition, regulation, information transmission, and contact inhibition in vivo. The structure of chitosan oligosaccharides is very similar to that of cells, and experiments have proved that chitosan oligosaccharides can directly act on cells, play a very good role in repairing damaged cells, and can restore cell functions and promote the growth of granulation ti...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P15/00A61K31/702A61K31/722
Inventor 冒华任杰陈兵张永煜
Owner 苏州瑞美科生物技术有限公司
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