Wound repair spray as well as preparation method and application thereof

Abstract

The invention relates to a wound repair spray as well as a preparation method and application thereof. The wound repair spray is prepared from 10 wt%-20 wt% of bioactive glass, 5 wt%-10 wt% of zinc hyaluronate, 50 wt%-70 wt% of solvent, 5 wt%-15 wt% of propellant, 0.1 wt%-0.5 wt% of film-forming agent and 1 wt%-5 wt% of penetration enhancer, wherein the solvent is 70 wt% ethanol aqueous solution with the pH value being 6-7; the weight ratio of the bioactive glass to the zinc hyaluronate is 2: 1; the bioactive glass is composed of Na2O, CaO, P2O5 and SiO2, the particle size of the bioactive glass is 40-60 [mu] m; and the molecular weight of the zinc hyaluronate is 10-15 kDa. The wound repair spray can greatly enhance the effect of bioactive glass on promoting wound healing and wound repair, is convenient to use, good in stability and low in irritation, and is particularly suitable for treating soft tissue ulcers or long-term erosion such as diabetic ulcers, diabetic feet, bedsores, sinus tracts or fat liquefaction wounds and the like.

Description

technical field [0001] The invention belongs to the technical field of wound bioactive dressings, and in particular relates to a wound repair spray and its preparation method and application. Background technique [0002] The treatment of wounds such as burns, scalds, soft tissue ulcers and long-term erosions is one of the difficult problems in the medical field. It can be said that there are almost no effective and simple drug treatments. Severely ill patients can only be treated by being hospitalized, cleaning the wound, disinfecting and changing the dressing every day, which makes the operation not only cumbersome, but also extremely painful for the patient. Previously, it was reported that bioactive glass could promote soft tissue healing. Bioactive glass (BAG) is made of Na 2 O, CaO, P 2 o 5 and SiO 2 Silicate glass composed of basic components. Bioactive glass can activate the expression of genes related to wound healing, promote the proliferation and differentia...

AI Technical Summary

Problems solved by technology

Studies have shown that Panax notoginseng saponins increase cell proliferation rate by regulating gene expression of cell proliferation and differentiation, but the specific mechanism of action is still unclear (see, for example, Li Jie et al., "For chronic wound carboxymethyl chitosan Preparation and performance evaluation of / oxidized glucomannan / total notoginseng saponins composite sponge", Chinese Tissue Engineering Research, Vol. 25, No. 16, pp. 2528-2534, October 21, 2020)

However, in the prior art, there is no combination of bioactive glass with specific types of notoginsenosides (for example, one or more of notoginsenoside R1, notoginsenoside S, notoginsenoside Fc, notoginsenoside Fa) Combined Use to Promote Wound Repair Reports

[0005] At present, most of the bioactive glass products used for wound repair are powders, gels, etc., which have the disadvantages of inconvenient use and greater irritation to the wound.

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