A kind of wound surface repairing spray and its preparation method and application

Abstract

The present invention relates to a wound repairing spray and its preparation method and application. The wound repairing spray comprises the following components: 10-20wt% bioactive glass, 5-10wt% zinc hyaluronate, 50-70wt% solvent, 5-15wt% propellant, 0.1-0.5wt% film-forming agent and 1-5wt% penetration enhancer, the solvent is 70wt% ethanol aqueous solution of pH 6-7, the weight of the bioactive glass and zinc hyaluronate ratio of 2:1, the bioactive glass consists of Na 2 O, CaO, P 2 o 5 and SiO 2 composition, the particle size is 40-60 μm, and the molecular weight of the zinc hyaluronate is 10-15kDa. The wound repair spray can greatly enhance the role of bioactive glass in promoting wound healing and wound repair, and is convenient to use, has good stability and low irritation, and is especially suitable for treating diabetic ulcers, diabetic feet, bedsores, sinuses or Soft tissue ulcers or long-term erosions such as fat liquefaction wounds.

Description

technical field [0001] The invention belongs to the technical field of wound bioactive dressings, and in particular relates to a wound repair spray and its preparation method and application. Background technique [0002] The treatment of wounds such as burns, scalds, soft tissue ulcers and long-term erosions is one of the difficult problems in the medical field. It can be said that there are almost no effective and simple drug treatments. Severely ill patients can only be treated by being hospitalized, cleaning the wound, disinfecting and changing the dressing every day, which makes the operation not only cumbersome, but also extremely painful for the patient. Previously, it was reported that bioactive glass could promote soft tissue healing. Bioactive glass (BAG) is made of Na 2 O, CaO, P 2 o 5 and SiO 2 Silicate glass composed of basic components. Bioactive glass can activate the expression of genes related to wound healing, promote the proliferation and differentia...

AI Technical Summary

Problems solved by technology

Studies have shown that Panax notoginseng saponins increase cell proliferation rate by regulating gene expression of cell proliferation and differentiation, but the specific mechanism of action is still unclear (see, for example, Li Jie et al., "For chronic wound carboxymethyl chitosan Preparation and performance evaluation of / oxidized glucomannan / total notoginseng saponins composite sponge", Chinese Tissue Engineering Research, Vol. 25, No. 16, pp. 2528-2534, October 21, 2020)

However, in the prior art, there is no combination of bioactive glass with specific types of notoginsenosides (for example, one or more of notoginsenoside R1, notoginsenoside S, notoginsenoside Fc, notoginsenoside Fa) Combined Use to Promote Wound Repair Reports

[0005] At present, most of the bioactive glass products used for wound repair are powders, gels, etc., which have the disadvantages of inconvenient use and greater irritation to the wound.

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