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Preparation method of traditional Chinese medicine composition for treating immune infertility

A composition and infertility technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of female infertility, sperm loss of motility, inapplicability, etc., and achieve good therapeutic effect Effect

Inactive Publication Date: 2012-10-17
河北省计划生育科学技术研究院
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The proportion of infertile couples caused by sperm-egg combination disorder due to various reasons reaches 95% in clinical infertility, and about 35% of them are due to the detection of male serum (or semen) or female serum (or cervical mucus) Antisperm antibodies are found to be positive, and the sperm loses its ability to move or is limited, or prevents the sperm from moving further through the cervix to the fallopian tube of the woman, so that the sperm and egg cannot combine to form a fertilized egg, resulting in infertility for the woman
Chinese patent document CN101569670B discloses a pharmaceutical composition for treating infertility, but the pangolin contained in the formula comes from the national Erji protected animals, and it also contains toxic ingredients such as centipedes and leeches, and it is mainly aimed at female fallopian tube obstruction, menstruation Infertility caused by irregularity, anovulation and uterine dysplasia, not applicable to infertility caused by positive anti-sperm antibodies of both couples or unilaterally

Method used

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  • Preparation method of traditional Chinese medicine composition for treating immune infertility
  • Preparation method of traditional Chinese medicine composition for treating immune infertility

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] (1) Preparation of the composition

[0014] Take 1 part by weight as 4 grams, weigh each component into a decocting pot according to the ratio in Table 1, add water equivalent to 3 times the weight of the total composition, soak for 40 minutes, and then heat at 85°C for 30 minutes , and the liquid obtained by gauze filtration is a decoction for later use.

[0015] (2) Clinical trials

[0016] Selection of positive cases of antisperm antibodies: According to the World Health Organization (WHO) Standard Inspection and Diagnosis Manual for Infertile Couples (1995), select couples who have had regular non-contraceptive sex and have not conceived after 1 year and the man’s semen Volume ≥ 2.0ml, liquefaction time ≤ 30 minutes, sperm density ≥ 20.0×10 6 / ml, forward motility sperm (types A and B) ≥ 50% or type A motility sperm ≥ 25%, normal sperm morphology ≥ 30% and the woman's menstrual cycle is normal, ovulation is regular, hysterosalpingography shows no abnormalities and...

Embodiment 2

[0019] [Example 2] to [Example 9], [Comparative Example 1] and [Comparative Example 2]

[0020] (1) Preparation of the composition

[0021] Except that the formula ratio adopted is different, others are the same as Example 1, and the formula ratios of each embodiment and comparative example are shown in Table 1.

[0022] (2) Clinical trials

[0023] Except that the sex of the positive cases participating in the clinical trial, the number of positive cases participating in the clinical trial are different, and taking the decoctions of the respective corresponding embodiments and comparative examples, they are all the same as in Example 1, and the clinical trial results are listed in Table 2 for ease of comparison. .

[0024] From the data given in Table 1 and Table 2, it can be seen that Capillaris and rhubarb in the composition of the present invention have an obvious synergistic effect in the treatment of immune infertility; In the invention of Codonopsis pilosula, Radix A...

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Abstract

The invention relates to a preparation method of a traditional Chinese medicine composition for treating immune infertility. The traditional Chinese medicine composition comprises the following components in parts by weight: 5 parts of capillary artemisia, 3-5 parts of scutellaria, 0.5-1.5 parts of prepared rhubarb, 3-5 parts of angelica, 2-4 parts of root of herbaceous peony, 1.5-2.5 parts of rhizoma atractylodis macrocephalae, 4-6 parts of herba leonuri, 2-4 parts of ligusticum wallichii, 2-4 parts of rhizoma anemarrhenae, 2-4 parts of golden cypress, 1-3 parts of herba andrographitis, and 4-6 parts of cuscuta chinensis. The preparation method comprises the following steps: a. soaking a required amount of components in water with the weight 2-4 times the total weight of the composition in a decoction container for 20-60 minutes; b. heating for 20-40 minutes at 55-100 DEG C; and c. separating out liquid to obtain decoction of the composition. The preparation method can be used in the production of the traditional Chinese medicine composition for treating immune infertility.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine composition for treating immune infertility, in particular to a preparation method of a traditional Chinese medicine composition for treating immune infertility caused by positive antisperm antibody reaction. Background technique [0002] The causes of infertility are divided into: ① Abnormal reproductive organs (including male or female reproductive structures). ② Sexual dysfunction (including endocrine abnormalities). ③Sperm-egg combination disorder. The clinical proportion of the first two types is about 5% in men and about 10% in women. The proportion of infertile couples caused by sperm-egg combination disorder due to various reasons reaches 95% in clinical infertility, and about 35% of them are due to the detection of male serum (or semen) or female serum (or cervical mucus) It is found that the anti-sperm antibody is positive, the sperm loses the ability to move o...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61P15/08
Inventor 高章圈田慧艳杜丽荣张玉
Owner 河北省计划生育科学技术研究院