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Radioactive biodegradable bile duct stent and preparation method thereof

A biodegradable, bile duct stent technology, applied in the field of biomedicine and polymer materials, can solve the problems of difficulty in taking out the pancreatic and bile duct stents, uncontrollable tumor development, deterioration of the disease, etc., so as to improve the curative effect, reduce the proliferative pathological reaction, and avoid aggravation. Obstructive effect

Inactive Publication Date: 2012-10-17
SHANGHAI FIRST PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Pancreaticobiliary stents currently used clinically have the following defects: although the stents can improve drainage, they cannot control the development of tumors, and often re-stenosis occurs due to the continuous proliferation of tumors. Therefore, many patients need to be replaced or re-implanted repeatedly In addition, many stents are difficult to remove when pancreaticobiliary restenosis occurs, mainly due to the hyperplasia of stimulated tissue or significant tumor tissue hyperplasia at the site where the stent is placed, and are tightly fitted with the stent, aggravating the stenosis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] First, mix polylactic acid and iodine 125 in a certain proportion; then, extrude the above mixture with a twin-screw extruder, and make a hollow tubular stent according to the anatomical characteristics of the human pancreaticobiliary duct. The outer diameter of the bile duct stent is 1.3cm, the inner diameter is 0.6cm, and the length is 7cm, and the outer diameter of the pancreatic duct stent is 0.8cm, the inner diameter is 0.4cm, and the length is 6cm; Cut 0.1cm thick and 0.3cm wide barbs (the length of the barbs is 0.7cm) into the four places of 1.5cm at both ends, and the directions are 0 o'clock, 3 o'clock, 6 o'clock and 9 o'clock. Radioactive biodegradable biliary stent.

Embodiment 2

[0022] Mix polycaprolactone, polyurethane and iodine 125 in a certain proportion; extrude the above mixture with a twin-screw extruder, and make a hollow tubular stent according to the anatomical characteristics of the human pancreaticobiliary duct, wherein The outer diameter of the bile duct stent is 1.3cm, the inner diameter is 0.6cm, and the length is 7cm, and the outer diameter of the prepared pancreatic duct stent is 0.8cm, the inner diameter is 0.4cm, and the length is 6cm; Cut 0.1cm thick and 0.3cm wide barbs (0.8cm in length) into the four places of 1.5cm each, and the directions are 0 o'clock, 3 o'clock, 6 o'clock and 9 o'clock to make radioactive Biodegradable biliary stent.

Embodiment 3

[0024] Mix polycaprolactone, polyurethane, polyurethane and iodine 125 in a certain proportion; extrude the above mixture with a twin-screw extruder, and make a hollow tubular stent according to the anatomical characteristics of the human pancreaticobiliary duct, wherein, The outer diameter of the prepared bile duct stent is 1.2cm, the inner diameter is 0.6cm, and the length is 7cm; the outer diameter of the prepared pancreatic duct stent is 0.8cm, the inner diameter is 0.4cm, and the length is 6cm; Cut 0.1cm thick and 0.3cm wide barbs (the length of the barbs is 0.6cm) into the four places of 1.5cm at both ends, and the directions of 0 o'clock, 3 o'clock, 6 o'clock and 9 o'clock to make radioactive Biodegradable biliary stent.

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Abstract

The invention, belonging to the field of biomedicine and high polymer material, relates to a radioactive biodegradable bile duct stent and a preparation method thereof. The radioactive biodegradable bile duct stent is a hollow tubular stent comprising biocompatible high-molecular degradable material and radioactive substance, is characterized in that the two ends are provided with barbed reverse beards, and accords with the anatomic characteristics of human pancreatic duct. The radioactive biodegradable bile duct stent disclosed herein can carry out radiosurgery on the tumors locally, especially for treating pancreaticobiliary malignancies, can reduce systemic side effect caused by radiosurgery while raising the curative effect, can be degraded in a certain time with no toxicity and no harm, can avoid continuous stimulation of permanent stents to lumen and organs in the body, and can avoid restenosis. The radioactive biodegradable bile duct stent has the advantages of simple preparation method, low price of materials, and strong practicality.

Description

technical field [0001] The invention belongs to the fields of biomedicine and polymer materials, and relates to a radioactive biodegradable bile duct stent and a preparation method thereof, in particular to a radioactive biodegradable bile duct stent which can be used for treating pancreaticobiliary malignant tumors and a preparation method thereof. Background technique [0002] Pancreaticobiliary malignant tumors with pancreaticobiliary obstruction are common clinical diseases with a high incidence rate; their onset is insidious, and most of them are found in the late stage, combined with obvious pancreaticobiliary obstruction, cholestasis, obstructive pancreatitis and other clinical symptoms It shows that about 60-70% of patients have lost the chance of radical surgery when they are diagnosed; some patients can only take non-surgical palliative treatment due to old age and infirmity or other serious diseases of other organs. However, the current palliative treatment method...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/06A61L31/16A61L31/14A61F2/82A61M36/12A61N5/00
Inventor 宛新建任天斌戚晓升张伟星陈颖黄超叶宽时翠红李斌
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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